Institution
University of Freiburg
Recent research
- BiologyOpen access
Abstract S-Adenosyl-l-homocysteine hydrolase (SAHH) reversibly cleaves S-adenosyl-l-homocysteine (SAH) into adenosine and l-homocysteine, regulating the cellular potential to perform S-adenosyl-l-methionine (SAM)-dependent methylation of DNA, RNA, proteins, and small molecules. A...
- Society & EconomicsOpen access
ABSTRACT Objective The role of the therapeutic alliance (TA) in treatment outcomes of anorexia nervosa (AN) appears to be less substantial than in other disorders. However, the therapeutic process is a complex trajectory with many variables influencing each other. Hence, investig...
- Climate & EnvironmentOpen access
Abstract Agricultural droughts in many humid regions such as Southern Germany are projected to become more frequent and severe, leading to a substantial rise in irrigation demand to secure crop production. As a result, irrigation is becoming an increasingly important factor in ag...
- AI & ComputingOpen access
Introducing GalaxyR: an easy-to-use R implementation of the Galaxy API
Abstract Background Standardisation, accessibility, and reproducibility remain persistent challenges in data‑intensive scientific research. The Galaxy platform addresses these issues by providing a web-based environment for executing, sharing, and publishing computational workflo...
- Materials & EnergyOpen access
Abstract The use of thiophenols on process scales is fraught with challenges relating to their toxicity, malodor, and air sensitivity. We previously demonstrated that the Ni-catalyzed C–S coupling of aryl iodides and thiourea provides a discovery-scale route to S-aryl isothiouron...
- Materials & EnergyOpen access
Electrospun polyacrylonitrile (PAN) / hexagonal boron nitride (h-BN) composite nanofibre membranes (h-BN: 0–40 wt%) were hydrolyzed with equimolar (2.0 M) NaOH and KOH, and the resulting fifteen compositions were characterized by SEM, ATR-FTIR, XRD, n -butanol porosimetry, and gr...
- BiologyOpen access
Acute respiratory viral diseases caused by single-stranded RNA (ssRNA) viruses like influenza A infection occur frequently in all age groups, with significant impact on morbidity and mortality worldwide. The severity and burden of the disease is tightly connected to host inflamma...
- Biology
Colonies of insects with morphologically distinct castes have been called superorganisms because the function of their queens and workers is analogous to the germline and soma in metazoan bodies. In the case of formicoid ants, workers typically have lost the sperm storage organ,...
- Health & MedicineOpen access
Abstract Background Acute myeloid leukemia (AML) is predominantly a disease of older patients with a poor long-term survival. Approval of the combination of venetoclax (VEN) with azacitidine (AZA) or decitabine (DAC) in the European Union in 2021 for the treatment of patients wit...
- Physics & Space
The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...
- Biology
Electrochemical in vivo oxygen sensing on cochlear implants
Abstract Cochlear implants (CIs) are the most frequently implanted neuroprostheses. Despite the clinical success of CIs, the processes actually occurring at the electrodes post-implantation remain unknown, and the majority of research is limited to endpoint analyses. Electrochemi...
- Climate & EnvironmentOpen access
Abstract Background Arboviral diseases remain major public health problems in Colombia. Mobile applications such as WhatsApp are increasingly being used to support health interventions by improving community engagement and preventive practices. Given its widespread use in Colombi...
- Engineering & TechnologyOpen access
Optical Detuning Strategies for Shielded Loop Resonators
ABSTRACT Purpose To compare detuning performance and evaluate power requirements of optical detuning methods and to demonstrate feasibility of an optically‐detuned 4‐channel receive array. Methods Four optical detuning methods were compared in simulations, bench tests, and phanto...
- Health & Medicine
Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective
Adoptive immunotherapies have emerged as a promising strategy in the treatment of hematological malignancies. To date, seven chimeric antigen receptor (CAR)-T cell products have obtained market authorization in Europe for B-cell malignancies, where they have revolutionized treatm...
- Health & MedicineOpen access
Background and Objectives: Superficial peritoneal endometriosis (SPE) remains one of the most difficult endometriosis phenotypes to diagnose non-invasively, because lesions are frequently small, multifocal, and poorly detectable using conventional imaging. Diagnostic laparoscopy...
- BiologyOpen access
Repetitive transcranial magnetic stimulation (rTMS) is widely used to modulate cortical excitability in clinical and experimental settings. Previous work has established that 10 Hz repetitive magnetic stimulation (rMS) reliably induces excitatory synaptic plasticity in mouse ento...
- BiologyOpen access
Von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome frequently associated with recurrent renal cell carcinoma (RCC), often requiring multiple renal interventions. Data on the timing and outcomes of repeated renal procedures remain limited. This study aimed to characte...