University of Edinburgh

High‐Pressure Synthesis of Quantum‐Stabilised Manganese Superhydride MnH 7

ABSTRACT Through high‐temperature, high‐pressure diamond anvil cell studies combined with in situ synchrotron powder x‐ray diffraction, we investigate the reactivity between manganese and hydrogen up to 182 GPa. Laser heating manganese in an medium at 118 GPa yields body‐centred...

High‐Pressure Synthesis of Quantum‐Stabilised Manganese Superhydride MnH 7

ABSTRACT Through high‐temperature, high‐pressure diamond anvil cell studies combined with in situ synchrotron powder x‐ray diffraction, we investigate the reactivity between manganese and hydrogen up to 182 GPa. Laser heating manganese in an medium at 118 GPa yields body‐centred...

Educational approaches to teach the 2017 periodontal classification to dental healthcare professionals: A scoping review

Abstract Background Diagnostic errors are a major concern, particularly when long‐standing diagnostic criteria are updated. Following the 2017 World Workshop on the Classification of Periodontal and Peri‐implant Diseases and Conditions, a new classification was released in 2018....

RNA degradation by DIS3 is a necessary step in the resolution of backtracked transcription complexes

Summary The RNA exosome is known to participate in transcription, but the contribution of its ribonuclease activities to this process remains unclear. Here we investigated the role of DIS3, one of the exosome ribonucleases, in transcription by RNA polymerase II (RNAPII). Rapid de...

Viperin as a putative antiviral effector in rainbow trout (Oncorhynchus mykiss) cells identified by CRISPR-Cas9 functional analysis following exposure to inactivated viral hemorrhagic septicemia virus

Abstract Viperin is recognized for its potent broad-spectrum antiviral activity; however, its role in the antiviral immune response of rainbow trout ( Oncorhynchus mykiss ) remains poorly characterized. In this study, the contribution of viperin to the innate immune response agai...

Integrated technologies of care: proof-of-concept study on an integrated physiological and activity monitoring system to enhance independence and care

Abstract This study presents a multi-sensor activity monitoring system designed to verify daily behaviours and detect physiological anomalies within a controlled home environment. Seven subjects participated in a scripted routine of Activities of Daily Living carried out in a hom...

Cross‐domain sustainability preferences in clothing and food: Evidence from environmental attitudes, stated confidence in producers claims and willingness‐to‐pay measures

Abstract Background Sustainability attributes increasingly feature in consumer products, but it remains unclear whether environmental and ethical preferences are consistent across clothing and food choices. Aims This study examines how environmental attitudes, stated choices and...

Strategic design of methane observation networks to improve emission estimates: A case study in Africa

Abstract. Ground-based and satellite atmospheric observations are essential for reducing uncertainties in methane (CH4) emissions by atmospheric inversion, particularly in data-sparse regions such as Africa. However, adding new observation sites does not yield linear improvements...

Celestial amplitudes on electromagnetic backgrounds: T-duality from S-duality

Abstract What is the boundary holographic dual of S-duality for gauge theories in asymptotically flat space-times? Celestial amplitudes, by virtue of exhibiting holographic properties of the S-matrix, appear well-suited for studying this question. We scatter electrically and magn...

Science as a global public good: responding to challenges of the modern era

Abstract Science has been crucial to the creation of the modern world and is essential in navigating its complexities. Well-informed citizens, willing to change perspectives in the face of new evidence, are essential to democracy. Recognizing science as a global public good, free...

The Association Between Chronic High-Altitude Exposure and Increased Pulmonary Vascular Resistance in Healthy High-Altitude Residents: A Systematic Review and Meta-Analysis

00:00-00, 2026. BACKGROUND: At high altitude, hypoxia triggers pulmonary vasoconstriction and vascular remodeling, potentially elevating pulmonary vascular resistance (PVR). Whether chronic high-altitude exposure raises PVR to clinically meaningful levels remain unclear, particul...

Integrable models from 4d holomorphic BF theory

We show how to construct 2d field theories with holomorphic integrability from defect setups in 4d holomorphic BF. In a simple example setup, we explicitly construct the 2d theory and perform an initial classical analysis. Making use of the symmetries, we are able to write down a...

Sulforaphane Decreases the Burden of AKT1-Expressing Pre-Neoplastic Cells in a Zebrafish Model of Glioblastoma Initiation

Background: Glioblastoma is a primary aggressive brain tumor, with an average survival rate of ~14.6 months. The low therapeutic benefit of current treatments is in part due to glioblastoma-initiating cells hijacking microglia/macrophages to support tumor growth, prompting the de...

Cardiovascular effects of chemoradiotherapy in patients with lung cancer: an [18F]FDG PET-CT imaging study

Abstract Background Cardiovascular and pro-atherogenic side-effects of chemoradiotherapy for non-small cell lung cancer (NSCLC) remain a major concern given the growing burden of cancer therapy-related cardiovascular disease. Atherosclerotic plaque burden can be measured using ca...

PPAD-Membership for Problems With Exact Rational Solutions: A General Approach via Convex Optimization

Abstract. We introduce a general technique for proving membership of search problems with exact rational solutions in PPAD, one of the most well-known classes containing total search problems with polynomial-time verifiable solutions. In particular, we construct a “pseudogate,” c...

Acceptability of advanced Controlled Human Infection Models: The case of a pneumococcal challenge in people living with HIV and mycobacterial challenge with Bacillus Calmette Guerin in Malawi

Abstract Background Controlled Human Infection Models (CHIM) in which volunteers are experimentally exposed to pathogens are used to study pathogenesis and down select among treatment and vaccine candidates. Scientifically, CHIM studies are best conducted among at-risk population...

Ketosis as a Treatment for Severe Mental Illness: A Critical Review of Preclinical and Clinical Data

Abstract Purpose Ketogenic interventions, including ketogenic diets, are increasingly being explored as potential treatments for severe mental illnesses. Ketosis – the metabolic state characterised by high circulating levels of ketone bodies – is thought to be central to the bene...

Evidence of a massive accretion event 1.8 billion years before the Gaia-Sausage-Enceladus merger

Abstract The merger history of the Galaxy has been traced back firmly to a redshift of 2 (10 billion years ago). While evidence for the existence of at least one more substantial merger before this time has been presented, its interpretation is yet to be fully established. Here w...

Translational evidence for the antihypertensive potential of Passiflora edulis: a systematic review of preclinical and clinical studies

Abstract Introduction Passiflora edulis (PE) (passion fruit) is traditionally valued for its cardiovascular and calming properties, but its antihypertensive and blood pressure (BP)-lowering potential has not been systematically evaluated. Emerging evidence from preclinical and cl...

Effect of chronic high‐altitude hypoxia on retinal vascular phenotype, choroidal and retinal vasoreactivity in Peruvian highlanders

Abstract High‐altitude chronic hypoxia can induce excessive erythrocytosis (EE, defined as a haemoglobin concentration of ≥21 g/dL in men), leading to hyperviscosity and promoting endothelial dysfunction. We aimed to assess whether EE affects the retinal vascular phenotype and th...