University of Cologne

Redox-dependent synaptic clustering of gephyrin

ABSTRACT Reactive oxygen species (ROS) play a central role in enhancing inhibitory signal transmission, thus extending their role beyond oxidative stress in disease and aging. However, the underlying molecular mechanisms mediating these functions have remained elusive. At inhibit...

Identification of a nanosecond isomer of $$^{164}$$Tb

Abstract This letter reports on the identification of a new isomeric state of $$^{164}$$ 164 Tb ( $$Z=65$$ Z = 65 , $$N=99$$ N = 99 ), which was measured with the DESPEC setup at the GSI Helmholtzzentrum für Schwerionenforschung GmbH following the first relativistic fragmentation...

Luminescence dating of offshore tsunami deposits from the Shetland Islands, United Kingdom

Abstract. With onshore geological evidence of three tsunami events, the Shetland Islands (UK) yield the most-detailed Holocene tsunami record in the North Sea region. Lately, tsunami deposits were also identified in shallow waters offshore the Shetland Islands. These offshore tsu...

INPP5E interactome reveals novel connections to growth factor signaling

Abstract Primary cilia are sensory cell membrane protrusions whose malfunction causes diseases known as ciliopathies. Joubert syndrome (JBTS) is a rare recessive ciliopathy causing brain malformations and kidney cysts, among other manifestations. A key player in JBTS is INPP5E, a...

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activatio...

A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer

Abstract Small cell lung cancer (SCLC) is one of the most aggressive malignancies, characterized by rapid metastatic dissemination and poor overall survival. Despite harboring excessive alterations, expectedly resulting in immunogenic neoantigens, patients with SCLC remain largel...

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

ABSTRACT Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Patients with IBD receive therapy to correct these imbalances and achieve remission. However, most patients...

How Norms Depend on the Presence and Status of Observers: The Relational Contingency of Everyday Behaviors in 90 Societies

Norms are fundamental to social life, but basic questions about how they are affected by social context remain. Specifically, how do normative constraints depend on the presence and status of observers, and how do such relational contingencies vary across cultures? Using data fro...

Artificial intelligence in mathematics education: a two-dimensional conceptual framework and meta-review

Abstract Artificial Intelligence (AI) is transforming mathematics education just as it is reshaping many other domains of modern life, creating new opportunities that fundamentally change the way students and teachers work. AI has become an increasingly prominent topic in mathema...

Effectiveness of an interactive music tablet intervention to reduce procedural anxiety in children: a randomized controlled trial

Abstract Procedural anxiety in children is common and associated with maladaptive behavior, reduced cooperation, and increased perioperative stress. Although music-based interventions show promise, few are designed for routine clinical care. We evaluated an interactive tablet-bas...

Existentializing Georg Simmel’s Sociology Through the New Phenomenology

Abstract The paper aims to reformulate two selected aspects of Georg Simmel’s concept of society and sociation by referring to New Phenomenology, founded by the German philosopher Hermann Schmitz. These are 1) the feeling of being an ‘I’, and 2), the reality of finding oneself in...

Determinants of mutation susceptibility along the genome are largely invariant across human tissues

Abstract Background The propensity for accumulating somatic mutations varies along the genome, which critically influences somatic mosaicism, tumor evolution and the potential role of somatic mutations in the context of age-associated diseases. Genomic factors contributing to the...

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS....

Atomic‐Scale Detection of Néel Vector Switching in the Single‐Layer A‐Type Antiferromagnet Cr 2 S 3 ‐2D

ABSTRACT The detection of Néel vector switching in a single‐layer A‐type antiferromagnet marks an important step toward functional two‐dimensional spintronics. Here, ‐2D, grown on graphene on Ir(110), is established as a first single‐layer A‐type antiferromagnet. Spin‐polarized s...

Integrated metabolomics data analysis to generate mechanistic hypotheses with MetaProViz

ABSTRACT With the growing number of metabolomics and lipidomics studies, robust strategies for bioinformatic analyses are increasingly important. However, the absence of standardized and reproducible workflows, coupled with ambiguous metabolite annotations, hampers effective anal...

‘Oh Dhar Obaran , Oh Cemetery of Bones!’ An Anti-Colonial Song from the Moroccan Rif as a Counter-Archive of Diasporic Memory

This article examines the transnational circulation of the anti-colonial Riffian song Dhar Obaran in contemporary socio-political contexts between Morocco and the Netherlands. Originating from the Rif region of northern Morocco, this epic poem is an essential part of Riffian oral...

Pre-service teachers' general pedagogical knowledge and pedagogical learning opportunities at entry into induction: comparing traditional and alternative teacher education programs

Globally, increasing numbers of individuals enter the teaching profession through alternative teacher education programs without prior university studies in teacher education or pedagogy. Compared to traditional programs, these alternative programs—for example, lateral entry prog...

Kinship Terms and Person Address in the English‐Speaking Sri Lankan Tamil Diaspora

ABSTRACT This article examines the impact of migration, globalization and digitalization on the use of nominal address terms in the English‐speaking Sri Lankan Tamil (SLT) diaspora community by undertaking a corpus analysis of English fiction authored by diaspora members with SLT...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

Benchmarking MeSH-augmented embeddings for biomedical document similarity

<title>Abstract</title> <bold>Background</bold> : The extensive volume of biomedical scientific literature requires efficient methods for retrieving relevant documents based on semantic technologies and biomedical concepts. While embedding-based methods have shown improvements ov...