University of Cologne

SEQUENCES WITH INEQUALITIES

Abstract We consider infinite sequences of positive numbers. The connection between log-concavity and the Bessenrodt–Ono inequality has been the focus of several papers. It has applications in the white noise distribution theory and combinatorics. We improve a recent result by Be...

Development of a multi-species luciferase-based double-antigen ELISA for the detection of antibodies against influenza A virus H5 clade 2.3.4.4b

ABSTRACT The highly pathogenic avian influenza viruses of subtype H5N1 represent a major threat to animal and public health. The current panzootic with H5 clade 2.3.4.4b has caused numerous, widespread outbreaks in various domestic and wild avian species with high mortalities, ma...

Conservative and surgical treatment of wrist osteoarthritis: a systematic review

INTRODUCTION: Wrist osteoarthritis leads to pain and functional impairment. Despite conservative treatment options, surgery remains a central therapeutic component. In Germany, the number of patients rose from over 472,000 cases in 2018 to more than 580,000 in 2024. This review e...

Bovines, buffers and barriers: A social scientific perspective on rewilding in the Kavango‐Zambezi Transfrontier Conservation Area

Abstract Rewilding is an increasingly popular nature conservation strategy globally. Originally, the strategy was formulated around the three C's of Carnivores, Cores and Corridors, which captured the ecological aim of rewilding to restore trophic interactions across large connec...

Mechanistic insights into phage dynamics to overcome intracellular bacterial reservoirs in urinary tract infections

Abstract Recurrent urinary tract infections frequently arise from uropathogenic bacteria invading bladder epithelial cells, where they establish persistent intracellular reservoirs. Phages represent a promising therapeutic alternative to antibiotics owing to their host specificit...

Female psychiatrists on screen: Cinematic stereotypes and therapeutic authority, 1935–2021

Throughout the 20th century, women entered psychiatry, yet cinematic representations remained structured by masculinised archetypes such as Dr Evil, Dr Wonderful, and Dr Dippy. This article interrogates depictions of female psychiatrists in nineteen films and one paradigmatic tel...

Stand structural differences along a degradation gradient in the National forest inventory of Georgia

Abstract Forest degradation assessments grounded in measurable structural indicators provide a more reproducible basis for management decisions than qualitative field classifications alone, particularly in ecologically diverse forest systems. Based on data from the first National...

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Heterozygous carboxyl-terminal variants in the RHO guanosine triphosphatase (GTPase) CDC42 are known to cause severe autoinflammatory syndromes. Here, we identified a heterozygous amino-terminal p.T43I (Thr 43 →Ile) CDC42 variant in patients with autoinflammation and uncovered a...

A genotype-first approach reveals the molecular basis of pyrin inflammasome activation

Mutations in the MEFV gene, which encodes pyrin, are associated with a spectrum of inflammatory conditions called pyrin-associated autoinflammatory diseases (PAADs). Of the 400 MEFV variants listed in the Infevers database, most are classified as variants of uncertain significanc...

Outside Back Cover: Cycloazulenylene

Cycloazulenylene exhibits a remarkably narrow HOMO–LUMO gap, intense absorption in the visible range, and a unique tubular packing in the solid state. In Research Article e2204400, Tomáš Slanina, Oliver Dumele, and co-workers strained the nonalternant azulene, known for its anti-...

Warum finanzielle Anreize verpuffen: Verhaltensökonomische Perspektiven auf wirtschaftspolitische Maßnahmen in der Energiekrise

Zusammenfassung Vor dem Hintergrund der Energiekrise 2022/23 und der Gefahr einer Gasmangellage suchte die deutsche Wirtschaftspolitik das Verbrauchsverhalten der Haushalte durch finanzielle Anreize zu beeinflussen. Markus Dertwinkel-Kalt und Matthias Sutter analysieren, warum hi...

Thyroid disorders, thyroid autoimmunity, and anxiety—a systematic review and meta-analysis of population-based studies

Objectives Previous studies, largely based on case–control samples, have suggested that hypothyroidism, hyperthyroidism, and thyroid autoimmunity may be associated with an increased risk of anxiety. However, whether a true association exists remains unclear, as population-based s...

The microbiological spectrum and clinical course of adolescents and adults with peritonsillar abscesses

A peritonsillar abscess (PTA) displays a purulent infection arising from acute tonsillitis, involving a variety of aerobic and anaerobic bacteria. Fusobacterium necrophorum, a gram-negative anaerobe, is considered a significant risk factor for complications like Lemierre's syndro...

Analysing the Evolution of Kenya’s Road Network since the 1950s using Historical andContemporary Road Datasets

Abstract. Kenya’s road network has undergone substantial but uneven transformation since the 1950s. This study compares historical road data derived from topographic maps using a deep learning-based extraction method with contemporary datasets from the Kenya Roads Board, in order...

Prosociality in times of war: Shared moral positions foster prosociality across national borders

In times of severe intergroup conflict, cross-national interactions are shaped by social categorization along national and moral dimensions. Yet, little is known about how these co-occurring identities jointly shape prosocial behavior. Across three studies (total N = 1178), we ex...

Repeated Renal Interventions for Renal Cell Carcinoma in von Hippel-Lindau Disease: Long-Term Outcomes

Von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome frequently associated with recurrent renal cell carcinoma (RCC), often requiring multiple renal interventions. Data on the timing and outcomes of repeated renal procedures remain limited. This study aimed to characte...

Nutrient stress activates RAB5B-mediated autophagy to remodel the synaptic proteome

Abstract Synaptic proteostasis is crucial for maintaining neuronal function and plasticity, yet how synapses adapt to metabolic stress remains poorly understood. Here, we show that nutrient deprivation, particularly serum withdrawal, induces robust autophagy-dependent remodeling...

Mesoporous Magnetic Nanoparticles Functionalized With Quaternary Ammonium Salts as Targeted Nanocarriers for Doxorubicin Delivery in Breast Cancer Therapy

Background: Nanotechnology offers promising strategies to overcome major limitations of conventional cancer chemotherapy, including poor targeting, systemic toxicity, and low drug bioavailability. This study focuses on developing a biocompatible magnetic nanocarrier modified with...