University of Cologne

Comparison of navigation and fluoroscopic assisted posterior spinal fusion in adolescent idiopathic scoliosis surgery

Abstract Purpose Intraoperative navigation is increasingly used in spinal deformity surgery. However, evidence comparing navigated and conventional fluoroscopic-assisted posterior fusion in adolescent idiopathic scoliosis is still heterogeneous and often lacks comprehensive perio...

Development of a prediction model for occupational satisfaction among cancer patients following counseling in German psychosocial cancer counseling centers

Abstract A prognostic model was developed and internally validated to predict satisfaction with the occupational situation among cancer patients receiving psychosocial counseling regarding return to work (RTW). Data were collected from outpatient cancer counseling centers in Germ...

Leptin-sensitive hypothalamic Lepr+/Glp1r+ neurons limit hyperphagia and weight gain in diet-induced obesity

Abstract Despite loss of responsiveness to exogenous leptin in obesity, endogenous leptin continues to restrain feeding, although the neural substrates that remain sensitive and mediate this effect remain unknown. Combining spatial transcriptomics with single-nucleus RNA sequenci...

Manufacturing Methodology for Single- and Multilayer Square Scintillating Fiber-Based Ribbons for Direct Coupling to Linear Photosensor Arrays

High-Energy and Nuclear Physics research facilities around the world demand cutting-edge instruments dedicated to exploring the signatures of particles knocked out by collisions at ultra-relativistic energies. Each instrument is a class of its own, but shares underlying technolog...

Clinical Outcomes in Placebo-Injection and Injection-Free Cohorts in Birch Pollen Allergy: An Exploratory Cross-Study Comparison

Background/Objectives: Placebo responses can complicate the interpretation of allergen immunotherapy (AIT) trials because symptom- and medication-based outcomes may be influenced by the trial context in addition to treatment-specific effects. Injection-free comparison cohorts are...

Respiratory Syncytial Virus Vaccination Strongly Induces RSVpreF-specific IgG and Neutralizing Activity in Immunocompromised Individuals.

Background: Protein-based respiratory syncytial virus (RSV) prefusion F (RSVpreF) vaccines show promising immunogenicity in immunocompromised individuals. We have recently shown that RSV-specific CD4 T-cell responses and IgG antibodies were significantly induced, but data on func...

Geriatric co-managed prehabilitation before esophagectomy in patients aged ≥ 65 years with esophageal cancer: a prospective feasibility study with matched historical controls

Abstract Purpose Older patients undergoing esophagectomy remain at high risk for perioperative morbidity. This study evaluated the feasibility, safety and adherence of a multimodal prehabilitation program integrated with geriatric co-management in patients aged ≥ 65 years schedul...

The global cost of schizophrenia: a health economic modelling study

Abstract Background Schizophrenia is a chronic psychiatric disorder that leads to substantial disability, impaired quality of life, and reduced life expectancy. In addition to its profound impact on affected individuals, the disorder places a considerable financial burden on heal...

Constraints on the Loss of Hydroperoxymethyl Thioformate (HPMTF) to Marine Clouds Using Aircraft Observations

Abstract The photochemical oxidation of dimethyl sulfide (DMS) by the hydroxyl radical (OH) contributes to the production and growth of particles and cloud condensation nuclei in the marine boundary layer (MBL). DMS oxidized by OH can go on to form a stable intermediate, hydroper...

Incidence and Predictors of Complications After Transcatheter Aortic Valve Implantation According to VARC‐3 Criteria: A Systematic Review and Meta‐Analysis

BACKGROUND: Despite continuous advancements in devices and techniques, transcatheter aortic valve implantation remains associated with complications impacting outcomes. In 2021, the Valve Academic Research Consortium (VARC) introduced the VARC-3 criteria to better classify proced...

Cadaveric training of total hepatic vascular exclusion for juxtahepatic venous injury: a technical study

Abstract Purpose Retrohepatic inferior vena cava (IVC) injury is a rare but frequently fatal challenge in trauma surgery. This study describes a structured cadaveric training sequence for total hepatic vascular exclusion (THVE), including transdiaphragmatic intrapericardial IVC e...

Submultiplicative polynomials in combinatorics

Abstract For normalized sequences $$\left( g(n)\right) _{n\in \mathbb {N}}$$ g ( n ) n ∈ N we consider recursively defined polynomials $$P_n^g(x)$$ P n g ( x ) . In this paper we study their submultiplicative property, viewed as a Bessenrodt–Ono type inequality for the partition...

Revisiting evidence for an attentional tunneling effect caused by scarcity

Abstract People in poverty sometimes behave in ways that perpetuate their socioeconomic condition. By one influential account, these behaviors arise from psychological effects of scarcity on attention that create greater focus toward managing scarce resources, at the cost of atte...

Spoilt for choice? dynamics of settlement patterns in early farming societies (c. 5400–4300 BCE) in Northwestern Bavaria and North Rhine-Westfalia, Germany

Settlement patterns of early farming communities are closely related to specific environmental parameters. However, these patterns change over time and vary regionally. To gain a deeper understanding of these dynamics, this study examines regional and diachronic differences in th...

Gender and other diversity-related factors in psychiatric hospital care: protocol for the participatory mixed-methods PSY-DIVER study

Psychiatric hospital care is multimodal and typically comprises pharmacotherapy, psychotherapy, social therapy, occupational therapy, exercise therapy, and various forms of creative therapies. The use, acceptance and effectiveness of these interventions may be shaped by gender an...

Identification of Changes in Gene Expression

ABSTRACT Evaluating the change in gene expression is a common goal in many research areas, such as in toxicological studies, which are particularly important in pre‐clinical research. In practice, the analysis is often based on multiple t ‐tests evaluated at the observed time poi...

Understanding Individual Differences in Prosocial Risk-Taking During Adolescence The Roles of Prosociality, Risk-Taking, and Social Orientation

Abstract Prosocial risk-taking, helping others at uncertain personal costs, has been proposed to emerge from the intersection of prosociality and risk-taking, suggesting that prosocial risk-taking is most likely to occur when adolescents are both motivated to help others and will...

Validation of EarthCARE CPR reflectivity using the ACTRIS cloud radar network

The Earth Cloud, Aerosol, and Radiation Explorer (EarthCARE) satellite carries a cloud profiling radar (CPR) designed to observe global cloud properties. In this study, we assess the calibration of CPR reflectivity profiles by comparing them with seven calibrated ground-based clo...

Mercury cycling during the last glacial period in Arctic Lake El'gygytgyn, NE Russia

ABSTRACT Tectonic processes play a key role in the global mercury (Hg) cycle on geological timescales, by mobilising Hg from deep Earth reservoirs to the surface. These natural fluxes also introduce a dynamic component to the terrestrial Hg cycle that can interact with other envi...

ERGA-BGE Reference Genome: Corema album ((L.) D. Don, 1830) - the Portuguese crowberry, endemic to the Iberian Peninsula.

Corema album is a perennial, dioecious shrub endemic to the Atlantic coast of the Iberian Peninsula and the Azores. It inhabits coastal dune ecosystems from Galicia to the Strait of Gibraltar, where it plays an important ecological role. The goal of this study was to assemble and...