University of Cologne

The microbiological spectrum and clinical course of adolescents and adults with peritonsillar abscesses

A peritonsillar abscess (PTA) displays a purulent infection arising from acute tonsillitis, involving a variety of aerobic and anaerobic bacteria. Fusobacterium necrophorum, a gram-negative anaerobe, is considered a significant risk factor for complications like Lemierre's syndro...

Analysing the Evolution of Kenya’s Road Network since the 1950s using Historical andContemporary Road Datasets

Abstract. Kenya’s road network has undergone substantial but uneven transformation since the 1950s. This study compares historical road data derived from topographic maps using a deep learning-based extraction method with contemporary datasets from the Kenya Roads Board, in order...

Thyroid disorders, thyroid autoimmunity, and anxiety—a systematic review and meta-analysis of population-based studies

Objectives Previous studies, largely based on case–control samples, have suggested that hypothyroidism, hyperthyroidism, and thyroid autoimmunity may be associated with an increased risk of anxiety. However, whether a true association exists remains unclear, as population-based s...

Prosociality in times of war: Shared moral positions foster prosociality across national borders

In times of severe intergroup conflict, cross-national interactions are shaped by social categorization along national and moral dimensions. Yet, little is known about how these co-occurring identities jointly shape prosocial behavior. Across three studies (total N = 1178), we ex...

Repeated Renal Interventions for Renal Cell Carcinoma in von Hippel-Lindau Disease: Long-Term Outcomes

Von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome frequently associated with recurrent renal cell carcinoma (RCC), often requiring multiple renal interventions. Data on the timing and outcomes of repeated renal procedures remain limited. This study aimed to characte...

Nutrient stress activates RAB5B-mediated autophagy to remodel the synaptic proteome

Abstract Synaptic proteostasis is crucial for maintaining neuronal function and plasticity, yet how synapses adapt to metabolic stress remains poorly understood. Here, we show that nutrient deprivation, particularly serum withdrawal, induces robust autophagy-dependent remodeling...

Mesoporous Magnetic Nanoparticles Functionalized With Quaternary Ammonium Salts as Targeted Nanocarriers for Doxorubicin Delivery in Breast Cancer Therapy

Background: Nanotechnology offers promising strategies to overcome major limitations of conventional cancer chemotherapy, including poor targeting, systemic toxicity, and low drug bioavailability. This study focuses on developing a biocompatible magnetic nanocarrier modified with...