University of California, Davis

Truncal Regional Analgesia for Thoracic Trauma

Abstract Purpose of Review Pain from chest wall trauma can worsen breathing in thoracic trauma patients and contribute to pulmonary complications. Standard analgesia with parenteral opioids and thoracic epidural analgesia can be very effective but cannot always be implemented saf...

Abridged Retinal Fluorescence Lifetimes in Glaucoma

This study investigates the relationship between glaucoma and retinal fluorescence lifetimes using FLIO. The results show that participants with glaucoma have shorter mean lifetimes compared to those without glaucoma, even after adjusting for age and diabetes status. The study su...

Abridged Retinal Fluorescence Lifetimes in Glaucoma

This study investigates the relationship between glaucoma and retinal fluorescence lifetimes using FLIO. The results show that participants with glaucoma have shorter mean lifetimes compared to those without glaucoma, even after adjusting for age and diabetes status. The study su...

Deletion of protein tyrosine phosphatase 1B in hepatocytes attenuates inflammation, steatosis, and fibrosis in a dietary mouse model of metabolic dysfunction-associated steatohepatitis

Abstract Background Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of liver-related morbidity and mortality. The current interventions are limited, underscoring the need for novel mechanism-based therapies. Protein tyrosine phosphatase 1B (PTP1B) regul...

Learning precise segmentation of neurofibrillary tangles from rapid manual point annotations

Accumulation of abnormal tau protein into neurofibrillary tangles (NFTs) is a pathologic hallmark of Alzheimer disease (AD). Accurate detection of NFTs in tissue samples can reveal relationships with clinical, demographic, and genetic features through deep phenotyping. However, e...

The First Highly Contiguous Genome Assembly for the Western bluebird ( Sialia mexicana )

The western bluebird (Sialia mexicana) is a secondary cavity-nesting thrush that has experienced historical population declines, local extirpations, and more recent recoveries associated with nest box programs. Despite these regional successes, recent eBird estimates suggest cont...

Multi-resolution enhancement for full-spectrum neural representations

Scientific data acquisition continues to outpace storage and analysis capabilities, making voxel-based representations increasingly intractable. Implicit neural representations (INRs) offer a promising solution by encoding signals through coordinate-based neural networks, serving...

Fabry Disease: An Updated Perspective and Review of Treatment and Therapies

Fabry disease (FD) is a progressive, multisystemic, X-linked lysosomal storage disorder that when untreated leads to decreased quality of life, chronic pain, and end organ disease; however, advances in therapy have significantly altered its original natural history. This paper br...

Clinical Behaviour and Outcome of Pelvic Osteosarcoma in Dogs: A Retrospective Multicentre Analysis of 74 Cases (2007–2025)

Although osteosarcoma is the most common primary bone tumour in dogs, involvement of the pelvic bones is rare. The aim of the present study was to describe clinical presentation, identify possible prognostic factors, and evaluate outcomes in dogs diagnosed with pelvic osteosarcom...

A pathological phosphorylation pattern enhances tau cooperativity on microtubules and facilitates tau filament assembly

Abstract Phosphorylation of the microtubule-associated protein tau plays important roles in both normal physiology and disease. While tau phosphorylation levels are similarly elevated in processes such as fetal development and hibernation and in pathological states like Alzheimer...

Enriched experience increases reciprocal synaptic connectivity and coding sparsity in higher-order cortex

The integration of new information during sleep reshapes cortical representations that support categorical knowledge. Auto-associative attractor network theories predict that reciprocal excitatory connections help form stable categorical attractors, but direct evidence is missing...

Thermal bottlenecks constrain early-life survival of native fish in regulated rivers

Climate change is reshaping thermal regimes worldwide, threatening species whose early development depends on narrow temperature ranges. Yet directly linking warming to reproductive failure in wild populations remains intractable, particularly in aquatic ecosystems. We developed...

The essential regularity of singular connections in geometry

Abstract This paper, a culmination of the authors’ theory of the Regularity Transformation (RT-)equations, accomplishes the following: (i) We discover there is a true (geometric) regularity associated with every affine connection, its essential regularity, the highest possible re...

Association between exposure to air pollution and age at natural menopause: The Study of Women's Health Across the Nation.

CONTEXT: Air pollution is a recognized risk factor for women's subfertility, yet its association with the timing of natural menopause remains understudied. OBJECTIVES: To examine the association between exposure to ambient air pollution and age at natural menopause (ANM). DESIGN...

The combination of morphogenic regulators BABY BOOM and GRF ‐ GIF improves maize transformation efficiency and promotes leaf regeneration

Summary Transformation is an indispensable tool for plant genetics and functional genomics. Although stable transformation in maize is no longer a major obstacle, there remains a need for accessible and efficient methods for academic laboratories. Here, we present the GGB system,...

Individual behavior and physiology of group housed mice in a spaceflight habitat

NASA has a robust history of biomedical investigations using rodent models in spaceflight. The results from these experiments have provided significant insights into the effects of spaceflight on mammalian physiological systems for fundamental, biomedical and commercial research...

Pixel super-resolved fluorescence lifetime imaging using deep neural networks

Abstract Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical adoption remains limited by long pixe...

The hematology workforce in the United States: past, present, and strategies for the future

From 2017-2021, the American Society of Hematology (ASH) completed the largest study ever conducted of the hematology workforce in the United States (US). The study highlighted a deficit in the classical hematology (CH) workforce: despite very high CH clinical volumes encountered...

Influence of many-body correlation and mixed-valence fluctuations on X-ray magnetic circular dichroism and resonant inelastic X-ray scattering spectra

X-ray magnetic circular dichroism (XMCD) and resonant inelastic X-ray scattering with magnetic circular dichroism (RIXS-MCD) provide unparalleled insights into the electronic and magnetic dynamics of complex materials. However, interpreting their spectra in mixed-valence systems...

Phylogenomic Taxonomic Analysis of Ralstonia solanacearum Strains causing Bacterial Wilt Disease in Northeastern Argentina

Ralstonia solanacearum species complex (RSSC) is a genetically diverse group of plant pathogens, yet genomic data from South America remain limited. Here, we characterize 13 RSSC strains isolated from tomato, pepper, and eggplant in northeastern Argentina. Phylogenetic analysis o...