University of California, Davis

Clinical Behaviour and Outcome of Pelvic Osteosarcoma in Dogs: A Retrospective Multicentre Analysis of 74 Cases (2007–2025)

Although osteosarcoma is the most common primary bone tumour in dogs, involvement of the pelvic bones is rare. The aim of the present study was to describe clinical presentation, identify possible prognostic factors, and evaluate outcomes in dogs diagnosed with pelvic osteosarcom...

Fabry Disease: An Updated Perspective and Review of Treatment and Therapies

Fabry disease (FD) is a progressive, multisystemic, X-linked lysosomal storage disorder that when untreated leads to decreased quality of life, chronic pain, and end organ disease; however, advances in therapy have significantly altered its original natural history. This paper br...

Enriched experience increases reciprocal synaptic connectivity and coding sparsity in higher-order cortex

The integration of new information during sleep reshapes cortical representations that support categorical knowledge. Auto-associative attractor network theories predict that reciprocal excitatory connections help form stable categorical attractors, but direct evidence is missing...

A pathological phosphorylation pattern enhances tau cooperativity on microtubules and facilitates tau filament assembly

Abstract Phosphorylation of the microtubule-associated protein tau plays important roles in both normal physiology and disease. While tau phosphorylation levels are similarly elevated in processes such as fetal development and hibernation and in pathological states like Alzheimer...

Thermal bottlenecks constrain early-life survival of native fish in regulated rivers

Climate change is reshaping thermal regimes worldwide, threatening species whose early development depends on narrow temperature ranges. Yet directly linking warming to reproductive failure in wild populations remains intractable, particularly in aquatic ecosystems. We developed...

The essential regularity of singular connections in geometry

Abstract This paper, a culmination of the authors’ theory of the Regularity Transformation (RT-)equations, accomplishes the following: (i) We discover there is a true (geometric) regularity associated with every affine connection, its essential regularity, the highest possible re...

Association between exposure to air pollution and age at natural menopause: The Study of Women's Health Across the Nation.

CONTEXT: Air pollution is a recognized risk factor for women's subfertility, yet its association with the timing of natural menopause remains understudied. OBJECTIVES: To examine the association between exposure to ambient air pollution and age at natural menopause (ANM). DESIGN...

The combination of morphogenic regulators BABY BOOM and GRF ‐ GIF improves maize transformation efficiency and promotes leaf regeneration

Summary Transformation is an indispensable tool for plant genetics and functional genomics. Although stable transformation in maize is no longer a major obstacle, there remains a need for accessible and efficient methods for academic laboratories. Here, we present the GGB system,...

Individual behavior and physiology of group housed mice in a spaceflight habitat

NASA has a robust history of biomedical investigations using rodent models in spaceflight. The results from these experiments have provided significant insights into the effects of spaceflight on mammalian physiological systems for fundamental, biomedical and commercial research...

The hematology workforce in the United States: past, present, and strategies for the future

From 2017-2021, the American Society of Hematology (ASH) completed the largest study ever conducted of the hematology workforce in the United States (US). The study highlighted a deficit in the classical hematology (CH) workforce: despite very high CH clinical volumes encountered...

Influence of many-body correlation and mixed-valence fluctuations on X-ray magnetic circular dichroism and resonant inelastic X-ray scattering spectra

X-ray magnetic circular dichroism (XMCD) and resonant inelastic X-ray scattering with magnetic circular dichroism (RIXS-MCD) provide unparalleled insights into the electronic and magnetic dynamics of complex materials. However, interpreting their spectra in mixed-valence systems...

Pixel super-resolved fluorescence lifetime imaging using deep neural networks

Abstract Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical adoption remains limited by long pixe...

Opioid prescription patterns for hidradenitis suppurativa in the emergency versus ambulatory care settings

Abstract Hidradenitis suppurativa (HS) is associated with significant pain. However, there is a paucity of literature examining opioid prescription patterns in HS in different healthcare settings. We aim to determine differences in opioid prescription patterns between HS patients...

Tracking the baryon number with nuclear collisions

Baryon quantum number is found to be conserved since baryogenesis in the early Universe. Conventionally, each fractionally charged valence quark is understood to carry one-third of a baryon number. An alternative hypothesis posits that baryon number is instead carried by a baryon...

Phylogenomic Taxonomic Analysis of Ralstonia solanacearum Strains causing Bacterial Wilt Disease in Northeastern Argentina

Ralstonia solanacearum species complex (RSSC) is a genetically diverse group of plant pathogens, yet genomic data from South America remain limited. Here, we characterize 13 RSSC strains isolated from tomato, pepper, and eggplant in northeastern Argentina. Phylogenetic analysis o...

Commensal bacteria inhibit viral infections via a tryptophan metabolite

Clinical outcomes following viral exposures exhibit substantial interindividual variability. Although developing evidence suggests commensal bacteria modulate viral infections, the specific bacteria and mechanisms remain underexplored. Here, we define a pathway by which viral inf...

Primary Care Clinical Rotations Are Associated with Shifts in Senior Veterinary Students’ Perceptions of Scope, Complexity, and Career Alignment

The study objective was to evaluate changes in senior veterinary students' perceptions of companion animal primary care and career preferences following a primary care clinical rotation. A multi-institutional survey was administered to veterinary students at 10 US colleges of vet...

Cranio-orbital craniotomy via an eyebrow incision for resection of anterior clinoid and tuberculum sella meningiomas

Abstract Background Anterior clinoid meningiomas (ACM) and tuberculum sella meningiomas (TSM) are anterior skull base tumors that commonly cause visual deterioration. The supraorbital keyhole approach may be used to resect these tumors but is limited by restricted intraoperative...

Early-life exposure to plastics is associated with health parameters and biomarkers in southern giant petrels

The sub-lethal effects of plastics and their associated chemicals on wildlife are poorly understood, primarily due to the lack of reliable indicators. We used southern giant petrels ( Macronectes giganteus, SGP), key scavengers and predators in southern seas, to assess whether ea...

Scintillator-IntegratedMicrochannel Plate PhotomultiplierTubes for Ultrafast Timing over keV–GeV Energy Scales

Abstract Precise measurement of radiation has long played a vital role in a wide range of research and industrial fields, from fundamental physics beyond the Standard Model to medical imaging such as time-of-flight positron emission tomography. Developing radiation detectors that...