University of Calgary

Technical note: Disentangling pre- and post-depositional thermal histories in partially reset samples

Abstract. Interpreting thermochronological data of a partially reset detrital sample is challenging because its age distribution reflects a mixture of each grain’s individual pre-depositional and the shared post-depositional thermal history. A promising approach to meet this chal...

Daratumumab, lenalidomide, and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: MAIA final survival analysis

Abstract In previous analyses of MAIA, daratumumab plus lenalidomide/dexamethasone (D-Rd) significantly improved progression-free survival and overall survival (OS) versus lenalidomide/dexamethasone (Rd) in transplant-ineligible newly diagnosed multiple myeloma (NDMM). We report...

Postural Orthostatic Tachycardia Syndrome (POTS)

Importance Postural orthostatic tachycardia syndrome (POTS) is a chronic autonomic disorder characterized by excessive orthostatic tachycardia and multisystem symptoms that affects an estimated 0.1% to 1% of the US population. POTS can substantially impair daily functioning and q...

Changing playing surfaces is associated with increased injury incidence and burden rates in men’s elite rugby union

This study examined the association between playing surface changes and match injury risk in professional men’s rugby in England. Nine seasons of injury data (2013/14–2021/22) were collected from 15 clubs. Incidence, severity and burden of injury were compared between conditions...

Digging with/in the spectacular: Child-dirt storied worlds

In this paper, we explore the narrative play, or what we are calling storied play, of a group of first-grade children over the course of a year in their suburban schoolyard, with particular attention to how the lively assemblages in which activities of digging in and with the dus...

Gut microbiome seasonality is associated with dietary plasticity and coexistence in three sympatric Pamir ungulates

This graphical abstract outlines a multi-omics framework investigating the seasonal dietary composition and gut microbial communities of three coexisting ungulate species inhabiting the extreme high-altitude Pamir Plateau (Ovis ammon polii, Capra sibirica, and Pseudois nayaur). B...

Piloting 3D technologies as a surgical simulation suite for patient-specific cochlear implantation surgeries in pediatrics

Abstract Background: Cochlear implants (CIs) help restore hearing in patients with severe to profound hearing loss. High-fidelity simulation tools may enhance surgical preparedness, patient safety, and training opportunities. This study validates the use of patient-specific 3D mo...

Primary Care Providers Journey with OSA Care, Challenges and Strategies: A Qualitative Study

Abstract Purpose Obstructive sleep apnea (OSA) is a treatable chronic condition associated with significant health and societal consequences. Primary care providers (PCPs) often manage OSA with support from sleep specialists but face challenges navigating a complex system of care...

Global agriculture shows limited evidence of a pollinator-driven yield decline to date

BACKGROUND: During recent decades, declines in the abundance and diversity of wild pollinators have been widely documented, largely driven by human-induced disturbance, such as agricultural expansion, land-use change, pesticide use, invasive species, urbanization, and climate cha...

Comparison of estimated personalized treatment rules under varying interference structures and treatment rates using dynamic weighted ordinary least squares

Dynamic treatment regimes (DTRs) are statistical methods that use patient-specific information to estimate an optimal sequence of treatments, with the end goal of maximizing a desired outcome of interest. DTRs have many useful applications to chronic disease management when patie...

“As soon as it’s trying to be persuasive, my skepticism kicks in”: A qualitative study to co-design vaccine communication strategies with vaccine hesitant adults in Canada

Vaccine hesitancy continues to impede vaccine uptake in Canada. Few interventions directly engage hesitant adults in co-designing communication materials. This study aimed to co-develop and evaluate digital vaccine communication messages with hesitant adults in Canada to improve...

Cell‐Type‐Resolved Proteomics Reveals Distinct Immune and Metabolic Programs Between Primary and Recurrent Ascites in HGSOC

ABSTRACT High‐grade serous ovarian carcinoma (HGSOC) frequently recurs after platinum–taxane therapy, yet recurrence‐associated changes within ascites remain unclear. We performed cell‐type‐resolved quantitative proteomics on paired ascites samples collected at primary diagnosis...

Comparative Analysis of Ion and Electron Contributions to Ionospheric Ionization at Auroral and Subauroral Latitudes

Abstract Electron and proton precipitation into the nightside ionosphere is a key process in magnetosphere–ionosphere coupling. Although auroral electron precipitation at –10 keV is traditionally considered the main driver of auroral emissions, recent studies show that keV electr...

Factors associated with severe COVID-19 outcomes among adults with at least a primary vaccination schedule: A retrospective cohort study from Alberta, Canada

Abstract Background With a large proportion of adults in Canada vaccinated against SARS-CoV-2, it is important to identify who remain at risk for severe COVID-19 outcomes after primary vaccination/additional (booster) doses. Methods Adults (≥18 years) who received at least a prim...

Molecular Designof Flotation Collectors: Impact ofan Allyl Group on Thionocarbamate Adsorption

Abstract Thionocarbamates, particularly N-ethyl O-isopropyl thionocarbamate (IPETC), are widely used as collectors in froth flotation. The recently developed N-allyl O-isobutyl thionocarbamate (AIBTC) shows broader applicability and enhanced recovery for coarse and fine particles...

Comprehensive inter-comparison of generative AI models for super-resolution precipitation downscaling across hydroclimatic regimes

Abstract. High-resolution precipitation information is essential for hydrologic modeling, flood forecasting, and climate-risk assessment, yet global weather and climate models operate at spatial resolutions too coarse to resolve storm structure, intermittency, and extremes. Deep-...

Performance advantages of attached-flow conditions over well-timed leading-edge vortices in flapping-wing turbines

Flapping-wing turbines (FWTs) have shown competitive power extraction efficiencies relative to conventional rotary turbines, as demonstrated in literature with high-fidelity simulations and limited experiments on physical prototypes. It has become accepted wisdom in academic circ...

IBAS: Interaction-bridged association studies discovering novel genes underlying complex traits

Genetic contributions to complex traits are often mediated through coordinated gene–gene interaction networks, yet most existing association frameworks focus on marginal single-gene effects and overlook higher-order dependency structures. Direct modeling of interactions remains c...

Exploring educators' awareness of and preparedness to respond to image-based sexual abuse and exploitation of children: A qualitative study

Background Educators and school administrators can play an important role in intervening in cases of image-based sexual abuse and exploitation of children (IBSAEC). However, these groups report they lack the knowledge and confidence to respond to suspected cases. Objective The ob...

Bias Testing and Mitigation in Black Box LLMs using Metamorphic Relations

The widespread deployment of Large Language Models (LLMs) has intensified concerns about subtle social biases embedded in their outputs. Existing guardrails often fail when faced with indirect or contextually complex bias-inducing prompts. To address these limitations, we propose...