University of Calgary

Seroprevalence of Peste des Petits Ruminants Virus Antibodies and Associated Factors in Small Ruminants Sampled Around Protected Wildlife Areas in Pakistan

Peste des Petits Ruminants (PPR) threatens small-ruminant production in Pakistan, particularly where livestock grazing overlaps with wildlife habitats. In this exploratory cross-sectional study (January–June 2024), 1939 sera from goats (n = 1327) and sheep (n = 612) in 56 herds,...

Evolution towards monomorphy leads to a loss of morph plasticity in wing polymorphic crickets

Threshold traits are widespread forms of dimorphism in which an underlying continuous liability produces discrete phenotypes once a threshold is crossed. The threshold trait model predicts that phenotypic variation will be observed only when the distribution of liability spans th...

Toward clinically actionable lupus biomarkers: a roadmap for research, validation, and translation

Abstract Despite advances in lupus biomarker research, clinical translation has remained limited, leading to delayed diagnosis, imprecise disease monitoring, and trial-and-error treatment approaches. This roadmap, developed by the Lupus Research Alliance’s Biomarker Roadmap Commi...

Musculoskeletal disorders and ergonomic risk factors among petrochemical control room operators with health promotion and intervention strategies

This study aimed to assess musculoskeletal and ergonomic risk, identify demographic, occupational, lifestyle, and biomechanical characteristics associated with these outcomes, and develop and prioritize ergonomic intervention strategies for petrochemical control room operators. T...

Imaging-based biological age estimation predicts competing mortality risk in lung cancer screening

Abstract Lung cancer screening (LCS) participants have a high competing risk of non-lung cancer related death, which limits screening benefit. We hypothesized that imaging-based biological age can identify individuals at higher risk of non-lung cancer mortality. Low dose computed...

EMU detection of mysterious multiple component radio-continuum emission from nearby spiral Seyfert I type galaxy ‘Sand-timer’ (NGC 7213)

We present an Australian Square Kilometre Array Pathfinder (ASKAP) Evolutionary Map of the Universe (EMU) radio-continuum detection of the nearby spiral Seyfert I type galaxy NGC 7213 which we nickname ‘sand-timer’ due to its morphological appearance. We find an intriguing and pe...

Propagating meteorological uncertainty in physically based mountain snow modeling

Abstract. Snow estimation in mountainous regions is uncertain because meteorology varies with topography, in situ observations are sparse and biased, and snow models have structural and scale limitations. Probabilistic methods are increasingly recognized as essential for quantify...

Characterization of a Unique Carbohydrate-Binding Module from Akkermansia muciniphila that Binds Ganglioside-Associated Glycans

Abstract Akkermansia muciniphila is a mucin-degrading gut symbiont that promotes host metabolic health through its ability to utilize host-derived glycans. Central to this microbe is its diverse set of glycoside hydrolases (GHs), specifically GHs involved in degrading host glycan...

A Remotely Delivered Exercise-Based Rehabilitation Program for Patients with Persistent Chemotherapy-Induced Peripheral Neuropathy (EX-CIPN): A Phase I Feasibility Trial

Background: Chemotherapy-induced peripheral neuropathy (CIPN) affects two-thirds of patients who receive neurotoxic chemotherapy. In almost half of these patients, CIPN is persistent, with limited treatment options. Exercise-based rehabilitation shows promising results in improvi...

Ultraprocessed Food Intake and Adiposity, Vascular Brain Injury, and Cognition in Middle-Aged Adults

Importance Ultraprocessed foods (UPFs) account for a substantial and increasing proportion of dietary intake in Canada. Although UPFs are consistently associated with adiposity and cardiometabolic disease, their associations with subclinical vascular brain injury (VBI) and cognit...

Modernizing Canada’s Regulations for Clinical Trials in Medical Emergencies

Keywords: clinical trials; emergency; stroke• Health Canada recently announced the publication of proposed Clinical Trial Regulations, with specific sections addressing consent practices for clinical trials in medical emergencies.• These regulations aim to simplify existing guide...

Use of Telestroke Prior to Endovascular Stroke Treatment in Canada: Results from the OPTIMISE Registry

BACKGROUND: Telestroke allows rapid assessment of acute stroke patients for intravenous thrombolysis and endovascular thrombectomy (EVT). While its safety and efficacy for thrombolysis are well established, evidence regarding EVT decision-making via telestroke is scarce. METHODS:...

Unlocking the potential of aquatic animal telemetry research to advance management and conservation: Barriers and a blueprint for Great Britain and Ireland

Aquatic animal telemetry research can provide important knowledge for how populations, anthropogenic pressures and, indeed, entire ecosystems are managed. However, the true scale, extent and impact in Britain and Ireland is poorly understood. We surveyed 53 researchers about past...

Surgical and Radiographic Outcomes in Cervical Deformity Patients with High T1 Slope and High C2 Slope (HTHC) Versus Low T1 Slope and High C2 Slope (LTHC)

Study Design. Retrospective analysis of a prospective multicenter operative cervical deformity (CD) database. Objective. To determine whether T1 slope (T1S) and C2 slope (C2S) together identify distinct CD phenotypes: cervical-only versus global sagittal deformity, and to compare...

Effects of neighbourhood socioeconomic disparity on preterm birth during the pandemic: secondary analysis of pregnancy during the pandemic cohort

Preterm birth (PTB) is a major public health concern with significant socioeconomic disparities. While stress-response pathways link neighborhood socioeconomic status (nSES) to PTB risk, overall PTB rates unexpectedly remained stable or declined during the COVID-19 pandemic. Give...

Chronic Ultrasound (‘Emotional’) Stress in Mice Exacerbates Colitis Through GSK3β-Mediated Neuroimmune Dysregulation and Is Ameliorated by Probiotic Intervention

Background: Growing evidence supports a bidirectional relationship between ‘emotional’ (psychological) stress and intestinal inflammation. ‘Emotional stress’, a form of stress that is triggered by negative information and experiences of non-physical nature, is an established risk...

Landscape of Canadian Stroke Motor and Cognitive Rehabilitation Trials: Trends, Strengths and Future Directions

ABSTRACT This study aims to systematically identify and describe all randomized controlled trials (RCTs) evaluating post-stroke motor and cognitive rehabilitation conducted in Canada, within the broader context of global post-stroke rehabilitation research. The present secondary...

Host‐mediated filtering and interspecific associations structure strongyle parasite communities in Sable Island horses

Mixed-species parasite infections are common in wildlife, yet the ecological processes that structure these communities remain poorly understood. We hypothesized that host-mediated and extrinsic environmental filtering, alongside biotic interactions, act concurrently to shape par...

Consented Universal Newborn Screening for Congenital Cytomegalovirus Infection Using Dried Blood Spot and Dried Saliva Spot Specimens: Implementation and Relative Programmatic Accuracy

The purpose of this research was to evaluate the implementation and relative diagnostic accuracy of dried blood spot (DBS) and dried saliva spot (DSS)-based newborn screening for congenital cytomegalovirus infection (cCMV). This prospective paired-sample pilot studied consecutive...

Interim Update on Reactive Infectious Mucocutaneous Eruption ( RIME )

ABSTRACT Reactive infectious mucocutaneous eruption (RIME), a term describing blistering skin and mucosal lesions, is a term coined by a group of Pediatric Dermatology Research Alliance (PeDRA) researchers and first published in 2021. Since that time, the literature has grown wit...