University of Calgary

Piloting 3D technologies as a surgical simulation suite for patient-specific cochlear implantation surgeries in pediatrics

Abstract Background: Cochlear implants (CIs) help restore hearing in patients with severe to profound hearing loss. High-fidelity simulation tools may enhance surgical preparedness, patient safety, and training opportunities. This study validates the use of patient-specific 3D mo...

Primary Care Providers Journey with OSA Care, Challenges and Strategies: A Qualitative Study

Abstract Purpose Obstructive sleep apnea (OSA) is a treatable chronic condition associated with significant health and societal consequences. Primary care providers (PCPs) often manage OSA with support from sleep specialists but face challenges navigating a complex system of care...

Comparative Analysis of Ion and Electron Contributions to Ionospheric Ionization at Auroral and Subauroral Latitudes

Abstract Electron and proton precipitation into the nightside ionosphere is a key process in magnetosphere–ionosphere coupling. Although auroral electron precipitation at –10 keV is traditionally considered the main driver of auroral emissions, recent studies show that keV electr...

Global agriculture shows limited evidence of a pollinator-driven yield decline to date

BACKGROUND: During recent decades, declines in the abundance and diversity of wild pollinators have been widely documented, largely driven by human-induced disturbance, such as agricultural expansion, land-use change, pesticide use, invasive species, urbanization, and climate cha...

Comparison of estimated personalized treatment rules under varying interference structures and treatment rates using dynamic weighted ordinary least squares

Dynamic treatment regimes (DTRs) are statistical methods that use patient-specific information to estimate an optimal sequence of treatments, with the end goal of maximizing a desired outcome of interest. DTRs have many useful applications to chronic disease management when patie...

“As soon as it’s trying to be persuasive, my skepticism kicks in”: A qualitative study to co-design vaccine communication strategies with vaccine hesitant adults in Canada

Vaccine hesitancy continues to impede vaccine uptake in Canada. Few interventions directly engage hesitant adults in co-designing communication materials. This study aimed to co-develop and evaluate digital vaccine communication messages with hesitant adults in Canada to improve...

Cell‐Type‐Resolved Proteomics Reveals Distinct Immune and Metabolic Programs Between Primary and Recurrent Ascites in HGSOC

ABSTRACT High‐grade serous ovarian carcinoma (HGSOC) frequently recurs after platinum–taxane therapy, yet recurrence‐associated changes within ascites remain unclear. We performed cell‐type‐resolved quantitative proteomics on paired ascites samples collected at primary diagnosis...

IBAS: Interaction-bridged association studies discovering novel genes underlying complex traits

Genetic contributions to complex traits are often mediated through coordinated gene–gene interaction networks, yet most existing association frameworks focus on marginal single-gene effects and overlook higher-order dependency structures. Direct modeling of interactions remains c...

Factors associated with severe COVID-19 outcomes among adults with at least a primary vaccination schedule: A retrospective cohort study from Alberta, Canada

Abstract Background With a large proportion of adults in Canada vaccinated against SARS-CoV-2, it is important to identify who remain at risk for severe COVID-19 outcomes after primary vaccination/additional (booster) doses. Methods Adults (≥18 years) who received at least a prim...

Bias Testing and Mitigation in Black Box LLMs using Metamorphic Relations

The widespread deployment of Large Language Models (LLMs) has intensified concerns about subtle social biases embedded in their outputs. Existing guardrails often fail when faced with indirect or contextually complex bias-inducing prompts. To address these limitations, we propose...

Comprehensive inter-comparison of generative AI models for super-resolution precipitation downscaling across hydroclimatic regimes

Abstract. High-resolution precipitation information is essential for hydrologic modeling, flood forecasting, and climate-risk assessment, yet global weather and climate models operate at spatial resolutions too coarse to resolve storm structure, intermittency, and extremes. Deep-...

Exploring educators' awareness of and preparedness to respond to image-based sexual abuse and exploitation of children: A qualitative study

Background Educators and school administrators can play an important role in intervening in cases of image-based sexual abuse and exploitation of children (IBSAEC). However, these groups report they lack the knowledge and confidence to respond to suspected cases. Objective The ob...

Molecular Designof Flotation Collectors: Impact ofan Allyl Group on Thionocarbamate Adsorption

Abstract Thionocarbamates, particularly N-ethyl O-isopropyl thionocarbamate (IPETC), are widely used as collectors in froth flotation. The recently developed N-allyl O-isobutyl thionocarbamate (AIBTC) shows broader applicability and enhanced recovery for coarse and fine particles...

Performance advantages of attached-flow conditions over well-timed leading-edge vortices in flapping-wing turbines

Flapping-wing turbines (FWTs) have shown competitive power extraction efficiencies relative to conventional rotary turbines, as demonstrated in literature with high-fidelity simulations and limited experiments on physical prototypes. It has become accepted wisdom in academic circ...

ConjugatedCoordination Polymer Aerogels with UnsaturatedSingle-Atom Metal Sites for Efficient Neutral Oxygen Evolution

Abstract Designing high-performance single-atom catalysts with a precisely designed configuration is important in extensive energy-conversion technologies, which presents enormous potentials to be extensively applied. Defect-enriched conjugated coordination polymer aerogels (d-CC...

Hair cortisol as a marker of physiologic stress in residency training

Hair cortisol analysis allows assessment of long-term cortisol exposure and may provide insight into chronic hypothalamic-pituitary-adrenal activation in medical residents and residency on-call responsibilities. To determine the hair cortisol concentration (HCC) representing 3 mo...

EMMPRIN-mediated metabolism of monocytes promotes disease progression in a mouse model of multiple sclerosis

Monocytes and monocyte-derived macrophages are increasingly recognized as key contributors to the initiation and progression of inflammatory conditions, in part through metabolic reprogramming that drives pathogenic inflammatory phenotypes. However, the upstream mechanisms that c...

Programming Ion‐Engineered Interphase for Practical Zinc Batteries Through Exogenous Cation‐Anion Synergy Chemistry

ABSTRACT A stable anode‐electrolyte interface is vital for battery cycling. Translating the successful anion‐derived interphase paradigm from Li‐ion to aqueous Zn‐ion batteries (ZIBs) is hindered by narrow electrochemical windows and chaotic interfacial reactions. Here we overcom...

Multiscale carbon burden of infrastructure in the United States

Anthropogenic greenhouse gas (GHG) emissions vary spatially with development patterns, climate, economic structure, and energy systems. Using Vulcan v4.0 fossil-fuel CO2 (FFCO2) data for the United States at 1-km resolution, this study examines how land use and infrastructure sha...

Programming Ion‐Engineered Interphase for Practical Zinc Batteries Through Exogenous Cation‐Anion Synergy Chemistry

ABSTRACT A stable anode‐electrolyte interface is vital for battery cycling. Translating the successful anion‐derived interphase paradigm from Li‐ion to aqueous Zn‐ion batteries (ZIBs) is hindered by narrow electrochemical windows and chaotic interfacial reactions. Here we overcom...