University of Calgary

Divergent biological consequences of APOE isoforms across industrialized and non-industrial environments

Abstract The apolipoprotein ε4 (APOE ε4) isoform directly alters cholesterol and immune biology and is associated with an increased risk of neurodegenerative and cardiometabolic disease in industrialized settings; nevertheless, APOE ε4—which is ancestral in humans—has persisted o...

Agency-Constrained Shared Autonomy for Prosthetic Grasp Selection: A Reproducible Offline Benchmark for Interactive AI in Assistive Robotics

Upper-limb prostheses increasingly combine user-intent decoding with contextual autonomy, improving robustness but risking reduced sense of agency when assistance overrides user control. We present agency-constrained shared autonomy (ACSA), which treats control authority as an ex...

Contemporary Fibrotic Interstitial Lung Disease Outcomes: A Multicentre National Cohort Study

ABSTRACT Background and Objective This study determined contemporary transplant‐free survival in fibrotic interstitial lung disease (ILD), identified baseline factors associated with death or transplant, and assessed performance of the ILD‐GAP (Gender, Age, Physiology) index in a...

Coca Leaves in Inka Rituals in Tambo Viejo, Acarí Valley, Peru

The Inka believed that the world around them was inhabited by powerful spirits and heavenly deities who had a strong influence on their lives. The Inka understood the importance of maintaining a good relationship with the spirits and deities to receive their positive influences....

Additive Manufacturing for Sustainable Electromagnetic Interference Shielding: Materials Discovery, Structural Optimization, and Machine Learning

ABSTRACT The rapid expansion of wireless technologies has intensified the need for effective electromagnetic interference (EMI) shielding to ensure the reliability of electronic devices, while the increasing generation of electronic and plastic waste has created a demand for sust...

Diabetes and Driving: How Predictive Technologies Will Alter Ethical and Legal Responsibilities

In 2023, a 67-year-old man with long-standing type 1 diabetes experienced a severe hypoglycemic episode and drove into an outdoor dining area in Victoria, Australia, killing 5 people and injuring several others. Although the charges against the driver were dismissed, future cases...

Optimizing MRI sequence selection for glioma classification: a radiomics-based analysis of WHO CNS grade, final pathological diagnosis, and IDH status

Abstract Background Multi-sequence MRI protocols for glioma classification are resource-intensive, prompting the need to identify optimal, potentially reduced imaging protocols. Purpose To evaluate the diagnostic utility of individual MRI sequences (ASL, DWI, FLAIR, SWI, T1w, T2w...

English Worldwide and Linguistic Justice: Past and Present

ABSTRACT This opening article of the special issue “English worldwide and linguistic justice” starts from the premise that more interdisciplinary work is needed that bridges sociolinguistic research with linguistic justice theories to provide deeper, more nuanced understandings o...

Mapping a monitoring landscape – review of monitoring systems related to the German bioeconomy

Abstract Background Moving away from fossil towards renewable resources to create a sustainable future is possible through the transition to a bioeconomy. Like any system, bioeconomy entails risks such as overexploitation of biotic resources, land and water, loss of biodiversity...

GIScience III: Slow GIS and intelligent automation

GeoAI’s rapid expansion makes renewed attention to slowness in GIScience necessary. Situating GeoAI within GIScience’s longer history of automation, this progress report revisits fast and slow geographic knowledge production and develops slow GIS as a critical orientation to inte...

A comparison of passive and quasi-passive prosthetic ankles over varying speeds and terrains

Quasi-passive (QP) prosthetic ankle-foot devices can provide functional benefits over passive prostheses without the complexity, weight, and cost of fully powered devices. However, research examining how to best design QP ankles to optimize patient outcomes is limited. This rando...

Beyond in silico prediction: multi-omics to identify a pathogenic deep intronic HNRNPK variant in Au-Kline syndrome

Abstract Pathogenic variants in HNRNPK are associated with autosomal dominant Au-Kline syndrome (AKS, Au-Kline-Okamoto syndrome, OMIM #616580). This syndrome is characterized by developmental delay and intellectual disability, hypotonia, and distinctive facial features. Despite t...

NeurHistAlert 29: History of neuroscience journal publications and theses, July 1, 2021 to June 30, 2022

Post R (2022): Environment, Sustainability, and Hellenic Studies. J. Hellen. Stud. 142: 317-333.This contribution offers a revisionist account of broader environmental histories of ancient Greece. ...

Local control of RCC pancreatic metastases is obtained by angiogenesis inhibitors

Background Metastatic clear-cell renal cell carcinoma (m-ccRCC) with pancreatic and/or thyroid metastases (PM/TM) is sensitive to vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs). Optimal first-line therapy for these patients (VEGFR-TKI-monother...

Remote Ischemic Conditioning in the Acute Treatment of Ischemic and Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background Remote ischemic conditioning (RIC), a low-cost, non-invasive therapy involving brief cycles of limb ischemia and reperfusion, may be a neuroprotective adjuvant or alternative to reperfusion therapies in acute ischemic stroke (AIS) and may also have therapeutic effects...

Fluid Injection Triggers Large‐Scale Slow‐Slip Activation of the Rocky Mountain Fold and Thrust Belt

Abstract Using interferometric synthetic aperture radar (InSAR) we show that hydraulic fracturing treatments near the subsurface deformation limit of the Rocky Mountain Fold and Thrust Belt produced 12 intraplate, aseismic, slow‐slip events with magnitudes 4.71–5.06 at 1,640–2,41...

Placentitis and abortion caused by canine distemper virus in a Linnaeus’s two-toed sloth

Canine distemper virus (CDV; family Paramyxoviridae , taxon species Morbillivirus canis ) causes systemic disease in a broad range of mammalian hosts. CDV commonly targets epithelial, lymphoid, and nervous tissues. Reproductive disease is reported less frequently. Here, we descri...

A quantum-inspired framework for real-time trust estimation in human–AI interaction: a pilot study

Abstract Trust is a determinant of effective human-AI collaboration, shaping whether users appropriately accept or reject system recommendations. In safety-critical domains, miscalibrated trust can lead to unsafe overrides or uncritical acceptance of erroneous outputs. However, e...

Consumer Perceptions and Behaviors Toward Fermented Foods: Insights From a Canadian Survey

ABSTRACT Chronic and autoimmune diseases continue to rise across Canada, demonstrating the need for sustainable dietary strategies that promote long‐term health. Fermented foods (FFs) have emerged as a potential approach, yet national data on consumption patterns and public perce...

Varifocal displays reduce the impact of the vergence-accommodation conflict on 3D pointing performance in augmented reality systems

This paper investigates whether a custom varifocal display can improve 3D pointing performance in augmented reality (AR), where the vergence-accommodation conflict (VAC) is known to impair interaction. Varifocal displays have been hypothesized to alleviate the VAC by dynamically...