University of Calgary

Establishing Stakeholder Priorities for Development of a Multi‐Arm Multi‐Stage Platform Trial in Crohn's Disease

ABSTRACT Background and Aims The expanding range of advanced therapies for Crohn's disease (CD) has increased complexity in treatment selection, particularly in refractory disease. Conventional randomised controlled trials are limited in evaluating multiple treatment strategies e...

Sex differences in mortality risk profiles across the life course in metabolic dysfunction-associated steatotic liver disease: a machine learning analysis of the Canadian Longitudinal Study on Aging

Abstract Background Prognostic models for metabolic dysfunction-associated steatotic liver disease (MASLD) are largely ‘one-size-fits-all’ and do not collectively account for sex differences and social determinants of health (SDoH). To address this gap, we trained and developed s...

Correlation of seasonal influenza rates with hospital-acquired Clostridioides difficile rates: Implications for research and interventions for prevention

Introduction: Hospital-acquired Clostridioides difficile infection (HA-CDI) rate variability can create challenges for assessing interventions that might improve rates. We therefore sought to assess whether seasonal trends in HA-CDI could be related to influenza rates by examinin...

Missed Child Communication Cues During Parent Technology Use and Child Language Development

This cross-sectional study investigates the association between parent technology use, missed child communication cues, and language production and comprehension in children aged 13 to 18 months.

Machine Learning in Air Pollution Research: Assessing Chemicals, CO, and NOx Exposure Effects on Liver and Endocrine Systems

Abstract Purpose Air pollution is a recognized threat to metabolic health, but the complex relationships between specific pollutant sources, exposure duration, and liver and endocrine outcomes remain poorly understood. Traditional statistical methods often fail to capture the non...

What’s behind the pain? Exploring physicians’ views on prescribing practices and structural factors that contribute to opioid use among Indigenous patients

Indigenous populations in Canada face an unequal burden of opioid-related issues, including significantly higher rates of opioid prescriptions, emergency room visits, hospital admissions, and opioid toxicity fatalities. Previous studies have identified factors that elevate the ri...

Investigating variability and uncertainty in upstream methane emissions intensity estimates of Western Canadian oil and gas production

Variabilities and uncertainties associated with different Canadian methane emissions inventories representing oil and gas (O&G) production impact the life cycle carbon intensities (CI) (i.e., amount of GHG emissions per unit of activity or output) of O&G end-use products. We pres...

In situ evidence of tiered adaptations buffering a chemosynthetic clam holobiont against environmental sulfide fluctuations

Deep-sea holobionts adapt to extreme environmental fluctuations, but the molecular mechanisms underlying resilience remain poorly understood. We investigated the vesicomyid clam Archivesica marissinica and its sulfur-oxidizing symbionts during sulfide shortage via in situ transpl...

Consensus-based clinical and research recommendations for use of glucagon-like peptide-1 receptor agonists in the context of eating disorders: a modified Delphi study.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for type 2 diabetes management and later expanded to obesity treatment, have shown preliminary efficacy in reducing binge eating episodes. However, the appetite-suppressing and weight-loss effects of GLP-1R...

Comprehensive profiling of brain dynamics during anesthesia across phylogeny

Abstract The behavioral effects of anesthetics are highly conserved across species, hinting at shared and fundamental underlying mechanisms. Here we compile a dataset of multiscale neural activity during wakefulness and anesthesia, encompassing human, macaque, marmoset, mouse, ze...

Canadian Paramedic User Requirements for Speech Recognition Aided Documentation

Objective: Developing technology may assist paramedics in the competing tasks of providing life-saving care and accurately documenting that care. The objective of this study was to identify and classify paramedic user requirements for speech recognition (SR)-aided documentation....

47. Effects of Mild Nutritional Restrictions During Mid-gestation on Neonatal Calf Performance and Placental Function in Extended-grazed Beef Cows.

Abstract Extended grazing (EG) is a cost-effective and sustainable winter-feeding strategy for the management of pregnant beef cows. In spring calving herds, EG often overlaps with mid-gestation, exposing cows to mild protein restrictions, potentially affecting placental developm...

Body Weight in Relation to the Effectiveness of Intravenous Alteplase in Acute Ischemic Stroke: The ENCHANTED Trial

BACKGROUND: The prognostic significance of body weight in patients receiving thrombolysis for acute ischemic stroke remains uncertain. This study aimed to determine whether body weight modifies the comparative effects of low- versus standard-dose intravenous alteplase and to eval...

Smash the Patriarchy?: Household Ties and Women’s Political Behavior in South Asia

The household is a difficult setting to study because its operations are, by design, not observable via public behavior. Violence within the household is often concealed; coordination over whom to vote for is not recorded; the bargains struck within marriage are rarely stated in...

Prehospital Stroke Treatment Trials in Conventional EMS Settings: An Expert Consensus Statement on Operational, Ethical, and Technological Priorities

Prehospital stroke trials enable assessments of ultraearly administration of treatments and management strategies, but face unique challenges in their design, conduct, and analysis. We outline important considerations and recommendations for planning prehospital stroke trials, fo...

Implementing living heritage education through school activity plans

Annual school activity plans often include cultural events, but their pedagogical value depends on whether students participate as passive attendees or active contributors. This study examines how a state-mandated school activity plan can be reframed as living heritage education...

Indigenous harvesters detect climate-sensitive emerging disease in barren-ground caribou (Rangifer tarandus) threatening food security

We report a filarioid nematode outbreak in barren-ground caribou ( Rangifer tarandus ) from the Canadian Arctic that was identified by Inuit harvesters through a community-based surveillance program. Harvesters reported discolouration of tissues and presence of yellowish fluid ac...

The impact of physical activity and exercise timing on metabolic health among individuals at high risk of type 2 diabetes

The timing of physical activity and exercise has been suggested to play a role in metabolic health. This narrative review synthesises current evidence on the impact of habitual physical activity and exercise timing on glucose homeostasis and insulin sensitivity, blood lipids and...

Multimode and Random-Access Optical Quantum Memory via Adiabatic Phase Imprinting

A photonic quantum memory that can store multiple qubits and later recall any randomly chosen subset is essential for large-scale quantum networking and computing. This capability, similar to random-access memory in classical computers, has been difficult to achieve due to the la...

Clinical Improvement, No Improvement, and Worsening at 24 Hours Following Reperfusion in Patients With Stroke due to Large-Vessel Occlusion

BACKGROUND: Restoring blood flow to ischemic tissue is the cornerstone of acute stroke therapy and is usually beneficial. However, when reperfusion is achieved for severely injured tissue, it is often futile and may occasionally cause harm. We aim to determine the prevalence and...