Université Paris-Saclay

Patient and parent voices in tetralogy of Fallot: A French social media analysis

AIMS: To analyse French-language public online conversations about tetralogy of Fallot (TOF), with emphasis on patient and parent concerns, emotional tone, and information needs relevant to congenital cardiovascular care. METHODS AND RESULTS: We conducted a retrospective observat...

Phylogeny-guided curation reveals widespread misannotation of Asgard archaeal 16S rRNA gene sequences in public databases

Abstract Accurate taxonomic assignment of 16S rRNA gene sequences is essential for the reliable interpretation of microbial community studies based on amplicon sequence data. Yet, it critically depends on the reliability of reference databases such as the Genome Taxonomy Database...

Functional niche partitioning influences species turnover across supraglacial microbial communities on the Longxiazai glacier, Tibetan Plateau

Glaciers represent unique ecosystems harboring diverse microbial communities that dominate biomass and drive biogeochemical cycling across supraglacial habitats. These microbes transform deposited modern and ancient carbon/nitrogen, and these elements are subsequently transferred...

Ancient DNA reveals early use of melons in China’s Song dynasty

Abstract Melon ( Cucumis melo L.) domestication is thought to have occurred independently once in Northeast Africa and twice in India, but archaeobotanical seed remains point to a possible additional domestication in China. Because Cucumis seeds are difficult to diagnose morpholo...

Defocus-Insensitive Microscopy via Spatial Phase Modulation Using End-to-End Learning

Abstract In optical microscopy, high spatial resolution comes at the cost of a short depth of field. This trade-off prevents the formation of sharp images of three-dimensional objects or objects moving in and out of focus. Moreover, it is often difficult to know the extent to whi...

Probing electron transport and thermodynamic properties in expanded warm dense matter

The expanded warm dense matter regime, an intermediate state between condensed matter and high-energy-density plasma at low density, remains poorly constrained experimentally, particularly regarding transport properties across the metal-to-nonmetal transition. Here, we explore ex...

Learning aligned EEG representations with subject-specific encoders

Cross-subject EEG decoding promises more training data, but it also exposes neural networks to strong inter-subject distribution shifts. We study whether task supervision and architecture alone can learn subject-aligned representations. We replace a shared EEG encoder with subjec...

Longitudinal evidence for decreasing statistical learning abilities across childhood

Abstract Statistical learning enables us to identify patterns in our environment and predict future events, thereby supporting a range of motor, cognitive, and linguistic skills. Despite its significance, the developmental trajectory of statistical learning has remained unclear d...

Identification of a nanosecond isomer of $$^{164}$$Tb

Abstract This letter reports on the identification of a new isomeric state of $$^{164}$$ 164 Tb ( $$Z=65$$ Z = 65 , $$N=99$$ N = 99 ), which was measured with the DESPEC setup at the GSI Helmholtzzentrum für Schwerionenforschung GmbH following the first relativistic fragmentation...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

Early development of cortical networks is modulated by Family Nurture Intervention: a multicenter replication study

Abstract Background Prematurity is associated with a high risk of abnormal neurodevelopment, inflicting life-long neurocognitive consequences with major public health importance. This calls for early biomarkers of functional brain development to serve as indicators of the effect...

Joint Inversion of Seismic and Geoelectrical Data Targeting Geological Faults

Near-surface geological faults play a crucial role in subsurface systems because they influence fluid flow and transport and can cause geotechnical failure. Topography can sometimes indicate the presence of fault zones, particularly in active tectonic settings where geomorphic fe...

Dry snow initialization and densification over the Greenland and Antarctic ice sheets in the ORCHIDEE land surface model

Abstract. Accurate modeling of the snowpack over ice sheets is essential for quantifying their surface mass balance contribution and their resulting impact on sea level rise. The snowpack evolution is largely governed by surface climate but also by internal processes such as dens...

Paleoenvironmental and paleoclimatic reconstruction in the Western Mediterranean during the Late Early Pleistocene

Abstract. The major climate change recorded during the Early-Middle Pleistocene Transition (1.4–0.4 Ma) is characterized by an increase in the length of climatic cycles from 41 to 100 ka. During this period, the Mediterranean climate underwent aridification associated with a drop...

Increased maximum carbon release offsets half of the growth trend in annual land carbon sink

The terrestrial carbon sink has strengthened in recent decades through enhanced maximum CO2 uptake (MCU) and a longer carbon uptake period (CUP), whereas maximum CO2 release (MCR) remains less quantified. Using atmospheric inversion estimates and 16 terrestrial biosphere models,...

Learning behaviour is consistent across time and tasks in Formica fusca ants

Abstract Research on interindividual behavioural and cognitive variability has gained momentum over the last few decades. Most studies focused on vertebrates, revealing that individual cognitive performance can be stable across time and tasks and linked to other behavioural trait...

DNA methylation either antagonizes or promotes Polycomb recruitment at transposable elements in Arabidopsis

Abstract Transposable elements (TEs) are usually silenced by DNA methylation and H3K9me2, but in the absence of DNA methylation they can instead acquire the Polycomb-associated mark H3K27me3. Here, we initially set out to test whether DNA methylation and H3K27me3 compete during T...

A first extraction of gluon TMDs from Higgs data at the LHC

Abstract We present the first extraction of the unpolarised gluon transverse-momentum-dependent (TMD) parton distribution from Higgs-boson production data at the LHC within the framework of TMD factorisation. The analysis is based on the currently available set of ATLAS and CMS m...

Real-World Use of Adjuvant Nivolumab for Resected Stage III–IV Melanoma: 2-Year Analysis of AdjuMel

Following the positive findings of the phase 3 CheckMate 238 trial, adjuvant nivolumab has become a standard therapy in patients with completely resected stage III–IV melanoma. The prospective, ongoing AdjuMel study is evaluating the real-world use, effectiveness, and safety of a...

Oral health, oral follow-up and infectious risk management of rheumatoid arthritis patients on anti-TNF drugs: a survey of a French e-cohort

Abstract Background As periodontitis is a recognized risk factor for rheumatoid arthritis (RA), it should be adequately treated before the initiation of biologic disease-modifying antirheumatic drugs (bDMARDs), along with any concomitant acute oral infection. bDMARDs remains a co...