Université Paris-Saclay

Irradiation Embrittlement in Grade-300 Steel Internals: A Comprehensive Description and Evaluation Approach

Water-cooled nuclear reactors are equipped with internal structural elements made of grade 300 steels, which are subject to embrittlement over their operational lifetime. More specifically, typical internal components are simultaneously exposed to neutron irradiation and pressuri...

Waterpipe smoke condensate activates autophagy in non-tumorigenic lung epithelial cells: Implications for inflammation and stemness

Waterpipe smoking has emerged as a major global health concern, with incompletely characterized effects on bronchial epithelial cells. In this study, we investigated the cytotoxic and adaptive responses of non-tumorigenic human bronchial epithelial BEAS-2B cells exposed to waterp...

Measurements of the production of W$$^{\pm }$$ and Z$$^0$$ bosons in pp collisions at $$\sqrt{s} = 13$$ TeV

Abstract Measurements of the production of the W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons at midrapidity in pp collisions at $$\sqrt{s} = 13$$ s = 13 TeV with ALICE at the Large Hadron Collider (LHC) are presented. The W $$^{\pm }$$ ± and Z $$^0$$ 0 bosons are detected via their (di)e...

Leveraging joint-specific phenotypes for genome-wide association studies and SNP heritability estimation of equine osteochondrosis and fetlock osteochondral fragments

Equine osteochondrosis (OC) and fetlock osteochondral fragments are prevalent developmental joint disorders caused by failure of the growing skeleton, often leading to intra-articular fragments that require arthroscopic surgery and impose substantial economic and animal welfare b...

Faster Hamiltonian Monte Carlo by learning leapfrog scale: an offline randomized solution

Abstract We introduce a Hamiltonian Monte Carlo (HMC) methodology based on an offline empirical calibration of randomized leapfrog parameters. The approach, referred to as eHMC, where e stands for empirical, leverages importance sampling to construct an empirical distribution on...

Quantitative approximation of a Keller–Segel PDE by a branching moderately interacting particle system and suppression of blow-up

Abstract The Keller–Segel PDE is a model for chemotaxis known to exhibit possible finite-time blow-up. Following a seminal work by Tello and Winkler (2007 Commun. Partial Differ. Equ. 32 849–77), a logistic damping term is added in this PDE and local well-posedness of mild soluti...

Direct spectroscopic identification of elusive dehydrogenated radicals: CH2OCHO and CH3OCO radicals from methyl formate oxidation

The atmospheric degradation of volatile organic compounds (VOCs) begins through oxidation by hydroxyl or nitrate radicals, producing highly reactive dehydrogenated radicals. While the stability-and thus, the reactivity-of these radicals critically depends on their isomeric form,...

JuRa: The Juventas Radar on Hera Mission to Probe Internal Structure of Didymos and Dimorphos Asteroids

Abstract JuRa, the Juventas Radar, is the sounding radar of the Hera/ESA mission on cruise to the asteroid Didymos and its moon, Dimorphos. In 2027, it will, for the first time, do direct observation of the internal structure of an asteroid for the benefit of both science and pla...

Five-country analysis of geographic and dietary drivers of gut microbiome composition and genomic variation

Abstract Human diet and lifestyle vary widely across cultures, shaping global diversity in gut microbiome composition and function. However, comparable cross-population studies have been limited by methodological heterogeneity. The Human Diets and Microbiome Initiative (THDMI) in...

Unprecedented In Vivo MRI Resolution of Basal Ganglia at 11.7 T

This case report describes 11.7-T in vivo human brain magnetic resonance imaging (MRI) of the basal ganglia in 2 healthy volunteers.

From online traces to upstream surveillance: Large language models uncover the hidden status of non-native freshwater apex predators in China

Biological invasions are often recognised only after ecological damage has become visible in the wild, even though the human-mediated processes that drive introductions may already be underway through private rearing, trade, and release. This gap in upstream surveillance is espec...

A memory of Paleozoic to Quaternary Greenhouse climates recorded in Southern African regolith

Abstract In this article, we explore the potential of iron-rich duricrust regoliths from old erosional anorogenic surfaces to record clues of the long-term continental paleoclimatic evolution. We coupled geochemical, mineralogical and geochronological analyses on iron oxides and...

Twenty-one years of three-way hybrid breeding shaped diversity and complementarity of male and female gene pools in sugar beet

Abstract Key message Three-way hybrid breeding in sugar beet is associated with strong genomic differentiation between male and female parental pools and persistent haplotypic differentiation at agronomically relevant loci over the last two decades. Abstract Three-way hybrid bree...

Dietary prevention of undernutrition reduces intestinal inflammation associated with an anti-inflammatory profile of gut microbiota in a preclinical model

Patients with inflammatory bowel diseases (IBD) have a high-risk for undernutrition. Undernutrition is associated with higher complications such as an increased mortality rate, a higher disease activity and an impaired quality of life in IBD patients. The aim of this study was to...

Re-schooling as a major outcome of « therapeutic and schooling » programs for adolescents with obesity

Background School absenteeism is a frequent but underrecognized consequence of adolescent obesity, with long-term implications for social and professional integration. Objectives To assess changes in school attendance among adolescents with complex obesity before and after partic...

Optimizing the Ocular Surface Before, During, and After Glaucoma Surgery: A Narrative Review

This narrative review synthesizes the published literature on ocular surface disease (OSD) and glaucoma filtration surgery to develop practical, evidence-informed clinical and surgical recommendations for optimizing ocular surface management before, during, and after surgery. The...

Lifetime exposure to atypical working hours among healthcare professionals compared with the workforce in other sectors: Nationwide cohort study

Background Despite well-documented health risks, cumulative exposure to atypical working hours (AWH) over a career remains poorly quantified, especially among healthcare workers. Objectives This study aimed to compare career-long AWH exposure among healthcare professionals and ot...

Sex-related variability of white-matter tracts is robust to tractography methodology

Abstract Diffusion tractography is the prominent in-vivo technique to study and investigate white-matter pathways in the human brain. While tractography is a powerful method, recent work suggests that different tractography methods can produce strikingly different representations...

The added value of considering evapotranspiration fluxes in the calibration of a semi-distributed hydrological model

Trust in hydrological model projections is often challenged by the model’s capacity to simulate streamflows under non-stationary conditions imposed by climate change. While many studies focus on uncertainties arising from climate scenarios or downscaling methods of climate projec...

Deciphering the genomic signatures of climate vulnerability across 77 sheep breeds

Abstract Among domesticated species, sheep ( Ovis aries ) have achieved a wide geographic distribution due to their mobility, rusticity and ability to adapt to diverse environments and climatic conditions. Here, we characterise the genome-wide diversity of >1,000 sheep representi...