Université Paris-Saclay

Mental health benefits of social prescribing in the general population and among people with mental disorders: an umbrella review

Social prescribing (SP) aims to connect patients to non-medical community resources to address social determinants of health. Here, we aimed to review the evidence of SP’s effects for mental health in the general population and among patients with mental disorders. We conducted a...

Deciphering the genomic signatures of climate vulnerability across 77 sheep breeds

Abstract Among domesticated species, sheep ( Ovis aries ) have achieved a wide geographic distribution due to their mobility, rusticity and ability to adapt to diverse environments and climatic conditions. Here, we characterise the genome-wide diversity of >1,000 sheep representi...

Tracking the Mechanism of Electrocatalytic Hydrodeoxygenation of Propylguaiacol by Electrochemical Membrane-Inlet Mass Spectrometry

Abstract Lignocellulose-derived bio-oils require hydrodeoxygenation (HDO) to reduce their oxygen content for integration into conventional fuels. Electrocatalytic HDO (eHDO) offers a sustainable alternative to traditional high-temperature, high-pressure processes, but its mechani...

Distinct migratory dendritic cell subsets cooperate to prime tissue-resident memory-like CD8⁺ T cells in mouse tumors

Tumor-infiltrating tissue-resident memory (TRM)-like CD8+ T cells correlate with positive prognosis and better responses to cancer immunotherapy, yet the mechanisms underlying their specification remain ill-understood. Here, we use the KP (KrasG12D, p53-/-) mouse model of lung ad...

Introducing shrubs enhances the representation of high-latitude vegetation and carbon cycling in the ORCHIDEE land surface model

Arctic–Boreal terrestrial ecosystems are rapidly changing under amplified high-latitude warming, including widespread expansion of shrubs, with consequences for regional carbon and energy balances. Yet, high-latitude vegetation diversity and vegetation–climate interactions remain...

Unsupervised deep learning for limited-angle STEM-EDX tomography: application to 3D chemical analysis of phase-change memory devices

Abstract Energy-dispersive X-ray (EDX) tomography in scanning transmission electron microscopy (STEM) enables three-dimensional elemental mapping at the nanoscale. However, its application remains challenging when sample geometry severely restricts the accessible tilt range, and...

Sugar metabolism drives shoot branching by repressing BRC1 through miR319 –targeted TCP4 in Rosa

Abstract The coupling between sugar availability and shoot branching is well established, yet the underlying molecular mechanisms remain largely unknown. Here, using genome-wide profiling, we characterized the sugar signalling pathways by identifying 10 microRNAs (miRNAs) repress...

Water Efficiency and Corporate Carbon Performance: The Roles of CSR, Regulation, and Industry Intensity

ABSTRACT This study examines whether firm‐level water management efficiency is associated with corporate carbon emissions, and whether this association is moderated by corporate social responsibility (CSR) performance, environmental regulatory stringency, and industry water inten...

A molecular safeguard in Escherichia coli Braun’s lipoprotein (Lpp) biogenesis

ABSTRACT Braun’s lipoprotein (Lpp) is the most abundant protein present in Escherichia coli . Lpp is an outer membrane (OM) lipoprotein that contributes to the mechanical integrity of the cell envelope by tethering the OM to the underlying peptidoglycan (PGN). It has long been kn...

The crosstalk of autophagy and metabolism in plants

Autophagy in plants promotes cellular longevity and nutrient recycling by degrading unwanted organelles and damaged cytoplasmic components. This process is essential for plant stress tolerance and nutrient management. In all plant organs, autophagy plays a critical role in mainta...

Quality of life and care experience in durable responders to immune checkpoint inhibitors for advanced or metastatic NSCLC or melanoma

Background Immune checkpoint inhibitors (ICIs) have transformed outcomes for advanced/metastatic melanoma and non-small-cell lung cancer (NSCLC), allowing for a growing population of ICI durable responders (ICI-DR). Despite improved survival, ICI-DR patients may face persistent h...

SARS-CoV-2 and RSV external quality assessment on molecular detection and variant typing in European expert laboratories in 2025

ABSTRACT We herein report on the fourth SARS-CoV-2 wet-lab external quality assessment (EQA) and the second organized by the AURORAE consortium to assess the diagnostic capabilities of European expert public health laboratories. Diagnostic capabilities were investigated regarding...

Net carbon losses in Central African forests revealed by high-resolution biomass change maps

Dense humid forests in Central Africa hold vast biomass carbon stocks but are increasingly affected by small-scale disturbances that are difficult to detect with current satellite observations. Here, we generate 10 m canopy height maps for 2019–2022 using deep learning with space...

Evidence for the impact of fire activity on daily variations of IASI mid-tropospheric CO 2 anomalies at 8–11 km over South America: a pyroconvective fingerprint

Biomass burning is a major, highly variable source of atmospheric CO 2 , but its impact on the free troposphere remains difficult to quantify because of uncertainties in injection heights and transport. In the tropics, intense fires can trigger pyroconvective plumes that loft com...

Identities Arising from a Certain Family of Special Combinatorial Numbers and Polynomials

The results obtained in this paper extend several identities and interpolation formulas previously established for the numbers y9,n(λ;a) to the higher-order case. We derive several explicit formulas, identities, and recurrence-type relations, and establish connections with well-k...

Mechanisms of non-monotonic signal dependence on repetition rate in high-repetition-rate nanosecond LIBS

High-repetition-rate nanosecond laser-induced breakdown spectroscopy (LIBS) offers advantages such as small ablation crater and high signal-to-noise ratio. To investigate the non-monotonic influence of repetition rate on signal intensity, we conducted high-repetition-rate LIBS ex...

The Characteristic Group of Lie LCP Manifolds

Abstract The (reduced) characteristic group of a locally conformally product manifold is obtained by restricting the action of its fundamental group to the non-flat factor of the universal cover, and taking the connected component of the identity in the closure of this restrictio...

Mental health and learning conditions among French physiotherapy students: a nationwide cross-sectional study of individual, educational and contextual factors

Learning conditions in health professions education may be associated with students’ mental health and academic experience. Physiotherapy training combines academic, clinical and relational demands, yet nationwide evidence on potentially modifiable educational factors remains lim...

Oxidized-Lipid Signaling and Ferroptosis as Downstream Mechanisms of Titanium-Associated Peri-Implant Bone Loss

Titanium and its alloys remain the dominant materials in oral implantology, but degradation products released through corrosion, tribocorrosion, and wear are biologically active. This critical narrative review examines oxidized-lipid signaling and ferroptosis as candidate downstr...

Appendicular Versus Non-Appendicular Community-Acquired Intra-Abdominal Infections: A Post-Hoc Analysis of the PERICOM Multicenter Study

Background: Community-acquired intra-abdominal infections (CA-IAIs) exhibit significant clinical heterogeneity. However, most studies focusing on CA-IAIs do not stratify comparisons by infection site. Methods: This post hoc analysis of the prospective multicenter PERICOM cohort (...