Université Paris-Saclay

Parabens and estrogen-mediated cancers: unraveling coincidence, co-occurrence, and causality

Abstract Paraben esters are endocrine disruptors linked to breast cancer, yet their role in other estrogen-mediated cancers remains limited. Preclinical evidence suggests that parabens accumulate in tissues and may promote carcinogenesis, while clinical data indicate widespread e...

Coupling of stable isotope probing and metagenomics reveals the diversity of viruses infecting formatotrophs during anaerobic digestion process

Abstract Background Viruses play a major role in regulating microbial community composition and activity, yet their diversity and host associations in anaerobic digestion (AD)—a complex biotechnological process converting organic waste into biogas—remain poorly characterized. Lin...

Death determination at the bedside: clinical judgement beyond criteria

In clinical practice, death determination—a core responsibility of critical care clinicians—is commonly taught as the technical application of standardized medical and legal criteria. However, contemporary practices, including resuscitation, death determination by neurological cr...

Bias in Genome-Wide Association Test Statistics Due to Omitted Interactions

Abstract Over the past two decades, genome-wide association studies (GWAS) enabled the discovery of thousands of variants associated with many complex human traits. However, conventional GWAS are still widely performed with linear models with the assumption that the genetic effec...

Structural Responses of Aluminoborosilicate Glasses to Pressure and Iodine Incorporation: An Advanced NMR Investigation

ABSTRACT Iodine‐129 is a critical challenge for nuclear waste immobilization due to its high mobility and extremely long half‐life (1.57 × 10 7 years). Although high‐pressure glass synthesis has been shown to significantly enhance iodine solubility, the structural mechanisms gove...

Access in all areas? A round-up of developments in market access and health technology assessment: part 16

In this update we review new evidence on the rising prevalence of prior authorization rejections, delays and denials affecting US patients seeking access to branded prescription medications. We also examine a comparative study of cost-effectiveness thresholds cited in the USA and...

A strong-coupling theory for polarizable symmetrically charged walls with counterions only

A pair of parallel polarizable planar walls at a distance d is considered. The walls are symmetrically charged with a uniform surface charge density, neutralized by mobile point counterions moving between them. The case of repulsive particle images is studied in the strong-coupli...

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids

BACKGROUND: Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis...

Testing the Effectiveness of Using Psychology-Intuitive Information to Promote Responsible AI: Information About the Training Set Shapes Perceptions of AI Algorithms in an Experimental Setting

Most of the tools currently available to promote responsible AI take a top-down approach, overlooking the role of intuitive perceptions of end users. However, emerging evidence shows that end users have preferences for specific algorithms, highlighting an alternative way to promo...

Post launch spectral and radiometric performances of MAJIS, the VIS-NIR imaging spectrometer of JUICE

Abstract. The post-launch spectral and radiometric performances of MAJIS, the VISNIR imaging spectrometer of the ESA Jupiter Icy Moon Explorer (JUICE), have been evaluated using observations performed during the Lunar-Earth Gravitational Assist (LEGA) of 19–20 August 2024 and obs...

Ecosystem-scale biogenic volatile organic compound fluxes over rapeseed by eddy-covariance

Abstract. Biogenic volatile organic compounds (BVOCs) are key precursors of ozone and secondary organic aerosols, yet their emissions from croplands remain poorly characterized. Here, we report what is, to our knowledge, the first ecosystem-scale quantification of BVOC fluxes ove...

ODIN: Confirmation and 3D Reconstruction of Six Massive Protoclusters at Cosmic Noon

Abstract Protoclusters represent sites of accelerated galaxy formation and extreme astrophysical activity characteristic of dense environments. Identifying massive protoclusters and mapping their spatial structures are therefore crucial for understanding how large-scale environme...

Differentiable Forward Modeling for Efficient and Accurate Shear Inference

Forthcoming Stage-IV dark energy optical surveys, such as LSST, have the ambitious goal of measuring cosmological parameters at sub-percent precision. Realizing their full scientific potential requires very precise measurement of the cosmic shear signal and control of correspondi...

Engine Position Effects on Contrail Evolution for a Realistic Aircraft Configuration

This study investigates the influence of representative engine positions on contrail evolution during the vortex and dissipation regimes, using three-dimensional simulations of a realistic aircraft geometry. Large-eddy simulations are employed, coupled with an Eulerian microphysi...

Comment on “The elusive fluid‐and‐crystal coexistence state in simulations of monodisperse, hard‐sphere colloids”

Abstract In a recent article [1], Wang et al. discuss the absence of simulations of monodisperse hard spheres in which a metastable fluid spontaneously nucleates into a stable fluid‐crystal coexistence. Here, we show that such a simulation can be readily accomplished with standar...

Vulnerable microbial communities in Atacama-Altiplano wetlands: modern analogs of ancient ecosystems with implications for sustainability and conservation

Abstract The Altiplano-Puna plateau lies at ∼4,000 m above sea level in the volcanic Andes cordillera. Together with the adjacent Atacama Desert, it forms one of the most hyperarid regions on the planet. Wetlands are rare, influenced by hydrothermalism and, due to high evaporatio...

Constitutive natural killer cell features associated with post-treatment control of SIV infection in the pVISCONTI study

Abstract Post-treatment HIV controllers (PTC) offer a unique opportunity to uncover the determinants of durable remission after antiretroviral therapy (ART) interruption. Here, using six PTC and six post-treatment non-controllers from the pVISCONTI study in cynomolgus macaques, w...

Cuproptosis: an emerging member of the immunogenic cell death family

Cell death was long considered the terminal consequence of cellular stress or damage, and distinct cell death modalities were classified according to their molecular execution mechanisms rather than their immunological impact [ 1 , 2 ]. This reductionist view has progressively be...

Earliest simultaneous multi-color optical observations of GRB 230328B: from 41 seconds to the host-galaxy identification

Abstract We present a multiwavelength study of the long-duration gamma-ray burst GRB 230328B, combining prompt γ-ray observations with exceptionally early simultaneous optical photometry and extensive X-ray, radio, and host-galaxy follow-up. NUTTELA-TAO began simultaneous g′r′i′...

Strategic design of methane observation networks to improve emission estimates: A case study in Africa

Abstract. Ground-based and satellite atmospheric observations are essential for reducing uncertainties in methane (CH4) emissions by atmospheric inversion, particularly in data-sparse regions such as Africa. However, adding new observation sites does not yield linear improvements...