Université Paris-Saclay

Cuproptosis: an emerging member of the immunogenic cell death family

Cell death was long considered the terminal consequence of cellular stress or damage, and distinct cell death modalities were classified according to their molecular execution mechanisms rather than their immunological impact [ 1 , 2 ]. This reductionist view has progressively be...

Constitutive natural killer cell features associated with post-treatment control of SIV infection in the pVISCONTI study

Abstract Post-treatment HIV controllers (PTC) offer a unique opportunity to uncover the determinants of durable remission after antiretroviral therapy (ART) interruption. Here, using six PTC and six post-treatment non-controllers from the pVISCONTI study in cynomolgus macaques, w...

Vulnerable microbial communities in Atacama-Altiplano wetlands: modern analogs of ancient ecosystems with implications for sustainability and conservation

Abstract The Altiplano-Puna plateau lies at ∼4,000 m above sea level in the volcanic Andes cordillera. Together with the adjacent Atacama Desert, it forms one of the most hyperarid regions on the planet. Wetlands are rare, influenced by hydrothermalism and, due to high evaporatio...

Earliest simultaneous multi-color optical observations of GRB 230328B: from 41 seconds to the host-galaxy identification

Abstract We present a multiwavelength study of the long-duration gamma-ray burst GRB 230328B, combining prompt γ-ray observations with exceptionally early simultaneous optical photometry and extensive X-ray, radio, and host-galaxy follow-up. NUTTELA-TAO began simultaneous g′r′i′...

Strategic design of methane observation networks to improve emission estimates: A case study in Africa

Abstract. Ground-based and satellite atmospheric observations are essential for reducing uncertainties in methane (CH4) emissions by atmospheric inversion, particularly in data-sparse regions such as Africa. However, adding new observation sites does not yield linear improvements...

A New Scale of Function Spaces Characterizing Homogeneous Besov Spaces

Abstract We introduce and study a new scale of function spaces that characterize the homogeneous Besov spaces $$\dot{\text {B}}^{\beta }_{p,q}$$ B ˙ p , q β , hence completing earlier work by Ullrich. These new spaces include the ones introduced by Barton and Mayboroda, and syste...

Misperceptions of charismatic species' conservation status: Zoo visits and virtual exposure shape perceptions of extinction risk

Abstract Biodiversity loss is accelerating globally, yet species are not equally affected, and public perceptions of extinction risk often diverge from scientific assessments. Understanding what shapes public perceptions is critical for effective conservation communication, parti...

Paediatric therapeutic development workshop on osteosarcoma

The fourth Paediatric Therapeutic Development Workshop focused on osteosarcoma, the most common primary bone cancer in children and young adults. Current treatment of osteosarcoma comprises surgery and chemotherapy. Outcome has shown very little improvement over the last four dec...

The limitations of non-mechanistic methods for characterizing pathogen-pathogen interactions: A simulation study

Abstract Pathogen-pathogen interactions occur when infection with one pathogen influences one’s chance of infection or disease due to another. Increasingly, evidence suggests that interactions are a common feature of infectious disease epidemiology. However, due to both the nonli...

Inlining as a Space Optimization: A Simple Time- and Space-Invariant Implementation of the Weak Lambda-Calculus

We propose an implementation model for the evaluation of the weak λ-calculus, which is invariant for both time and space complexity, in both call-by-name and call-by-value strategies. In other words, this model provides an implementation of any weak call-by-name or weak call-by-v...

Breast cancer metabolism and responsiveness to dichloroacetate: relationships with 15N and 13C natural abundance

Abstract Background Metabolic reprogramming is a hallmark of breast cancer (BrCa), with alterations in glycolysis, glutamine metabolism, and the urea cycle contributing to tumour progression. Dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, shifts metabolis...

Toward Climate-Responsive Ocean–Terrestrial Biorefineries: Integrating Algae and Agricultural Residues for Circular Bioeconomies

Abstract This paper evaluates climate-responsive biorefineries that integrate pelagic Sargassum with agricultural residues to advance circular bioeconomies. Building on scientific priorities emphasized at the 2025 One Ocean Science Congress and emerging policy directions from the...

Fabricationof Co and Ni Phosphide Nanomaterials byDLI-CVD Using Single-Source Precursors for Electrocatalytic Applications

Abstract Transition-metal phosphides (TMPs) are emerging as versatile materials for diverse applications, yet their scalable fabrication remains a critical challenge, limiting industrial adoption. Here, we report the direct liquid injection chemical vapor deposition (DLI-CVD) of...

HighlyTransparent Layer-by-Layer Nanoassembled MulticomponentFilms of TiO2 and Graphene for Increased PhotocatalyticPerformance

Abstract Here, we report novel highly transparent and photoactive multicomponent films for enhanced photocatalytic applications. Some films are based on intimately interfaced TiO2 nanoparticles and few-layer graphene (FLG) assembled through an environmentally friendly aqueous lay...

GRB 260310A / SN 2026fgk: A Multi-Wavelength Study of a Nearby Underluminous Long GRB and SN with a Complex Afterglow

Abstract We present a comprehensive multi-wavelength study of GRB 260310A / SN 2026fgk, a nearby (z = 0.153), long-duration gamma-ray burst (GRB) with an exceptionally underluminous prompt γ-ray emission and a Comptonized spectrum. The burst occurred at the edge of a blue host ga...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

Occurrence and controls of ~ 1 Hz waves in Mercury’s magnetosphere: insights from MESSENGER observations

<title>Abstract</title> Mercury’s magnetosphere is highly dynamic, with processes occurring on much shorter spatial and temporal scales than at Earth due to its weak magnetic field and proximity to the Sun. Wave-driven transport of energy and momentum is a key manifestation of th...

Mapping structural heterogeneity in three-dimensional biophotonic gyroid networks using position-resolved small-angle X-ray scattering

Abstract The wings of select Papilionid and Lycaenid butterflies contain a three-dimensional gyroid network of a solid cuticle phase in air. In butterfly scales, gyroid networks are optically interesting, as they create the green colour observed in the wings of these butterflies....

Neutron elastic scattering at $$\varvec{30.8}$$ MeV on $$\varvec{^{\text {nat}}\textrm{Ce}}$$

Abstract Elastic scattering of fast neutrons at an incident energy of 30.8 MeV on a natural cerium target was measured during an experiment conducted at the Neutrons For Science facility at GANIL-SPIRAL2. This is the first measurement on cerium using incident neutron energy above...

Trace Elements in Total Atmospheric Deposition Directly Measured Over the Caribbean Region: Natural Versus Anthropogenic Sources and Geographic Origin

Abstract Dust, sea salt, and anthropogenic and biogenic particles in total atmospheric deposition are sources of essential elements that can significantly impact biogeochemical cycles in the Atlantic Ocean and in islands of the Caribbean region. This unique 41‐month data set reco...