Universidade do Porto

Early mechanical changes of limb muscle in septic shock assessed by dual-plane shear-wave elastography

Abstract Background Septic shock induces skeletal muscle wasting and neuromuscular dysfunction, contributing to ICU-acquired weakness (ICUAW) and poor recovery after critical illness. Conventional ultrasound primarily captures structural changes but provides limited insight into...

Changes in Cardiovascular Health and Functional Fitness Following Multicomponent Exercise Training in Community-Dwelling Older Women

Background: Multicomponent exercise promotes healthy aging, but evidence in community-dwelling older women remains limited. This study examined pre–post changes in functional fitness and cardiovascular health following participation in a six-month multicomponent exercise program....

Pharmacokinetic Variability of Direct Oral Anticoagulants and Calcium Channel Blockers: A Comparative Analysis of Exposure Data from Clinical Studies

Background/Objectives: Interindividual pharmacokinetic (PK) variability remains a daunting challenge for effective and safe drug therapy. Despite the widespread use of direct oral anticoagulants (DOACs) and calcium channel blockers (CCBs), a substantial number of adverse drug rea...

A performance‑driven framework for designing low‑carbon binders for self‑compacting concrete

Self-compacting concrete (SCC) combines high flowability with good mechanical performance, but achieving this typically requires high binder contents, increasing its environmental footprint. This study investigates the design of low-clinker self-compacting mortars (SC-Mortars) in...

An Initial Integration of Constructs That Account for Moral Actions: Moral Foundations, Values, and Character Strengths

Morality has been described as a psychological system comprising sets of values, practices, institutions, and psychological mechanisms that work together to support moral/socially positive behavior. Nonetheless, there have been relatively few efforts to integrate these diverse co...

Classification of Seasonal Allergic Rhinitis Patients by Prospective Patient‐Recorded Symptoms: The @ IT .2020 Project

BACKGROUND: Seasonal allergic rhinitis (SAR) has been so far classified according to frequency and severity by retrospective information based on the ARIA (Allergic Rhinitis and its Impact on Asthma) classification. Electronic symptom diaries (e-Diaries) are feasible tools to col...

The Era of Influencer Journalism: A Multifaceted Transformation of the Global News Landscape

If, ten years ago, someone had told me it would be possible to access news through digital influencers, I might have had some difficulty believing it and could even have thought I was facing some sort of dystopia in the media landscape [...]

Frameworks to identify research gaps, frame research needs, and derive research priorities from evidence syntheses:a scoping review

Objectives To identify and describe frameworks for systematically identifying research gaps from evidence syntheses, framing research needs, and establishing priorities, with emphasis on their use of GRADE (Grading of Recommendations Assessment, Development and Evaluation) certai...

The role of controllable household appliances for effective uptake of digital services by consumers and communities in the energy transition

Digitalisation is transforming modern energy systems into complex socio-technical ecosystems where interconnected devices, user practices and governance structures must be considered together. To analyse this landscape and address relevant research questions concerning controllab...

Overview of the re‐evaluation of trace elements as nutritional feed additives in the European Union : characterization, safety, and efficacy

The re-evaluation of feed additives in the European Union was outlined in the Regulation (EC) No 1831/2003. The primary objectives were to ensure safety and verify efficacy, as well as to update authorizations and phase out unsafe additives or those in which the industry expresse...

Myeloma Elderly Prognostic Score ( MEPS ): A Proposed Prognostic Score Integrating Age, Renal Function, Performance Status, and Ultra‐High‐Risk Cytogenetics

Established disease-centered prognostic systems may be less tailored to elderly/non-transplant-eligible (NTE) patients with multiple myeloma (MM), in whom host-related factors such as age, performance status, and renal function strongly influence all-cause outcomes. We developed...

Dynamics of the Leftmost Particle in Heterogeneous Semi-infinite Exclusion Systems

We study the behaviour of the leftmost particle in a semi-infinite particle system on Z, where each particle performs a continuous-time nearest-neighbour random walk, with particle-specific jump rates, subject to the exclusion interaction (i.e., no more than one particle per site...

Event-related potentials reveal enhanced processing of social media over monetary rewards

Since the first online social media platform, using social media has emerged as one of the defining behaviors of the new millennium. For most users such behavior is recreational. However, for some individuals, the use of social media may develop to problematic, compromising their...

Viperin as a putative antiviral effector in rainbow trout (Oncorhynchus mykiss) cells identified by CRISPR-Cas9 functional analysis following exposure to inactivated viral hemorrhagic septicemia virus

Abstract Viperin is recognized for its potent broad-spectrum antiviral activity; however, its role in the antiviral immune response of rainbow trout ( Oncorhynchus mykiss ) remains poorly characterized. In this study, the contribution of viperin to the innate immune response agai...

Nature-Based Solutions for Office Workers: A Randomized Controlled Trial on Indoor Plants to Enhance Well-Being and Productivity

Most of the global population lives and/or works in urban areas with limited access to green spaces. Integrating nature-based solutions (NBS) into indoor environments has emerged as a promising intervention strategy for enhancing indoor environmental quality (IEQ) and promoting h...

Effect of Dentin Pretreatment Strategies on Bond Strength to Natural Caries-Affected Dentin: A Systematic Review

Background: This systematic review aimed to evaluate the effect of dentin pretreatment strategies on bond strength to natural caries-affected dentin (NCAD) in permanent human teeth. Methods: A systematic search was conducted in PubMed, Web of Science, and Scopus databases up to A...

Emergency Construction in Remote Locations Using Large-Scale 3D Printing: Literature Review and Research Perspectives

Large-scale 3D printing has emerged as a potentially transformative technology for emergency construction in remote and disaster-affected areas, offering rapid, sustainable, and economically viable solutions. This article presents a literature review examining the advances, chall...

Validation of the Individuation Test for Emerging Adults-Short (ITEA-S) in Spanish and Portuguese Emerging Adults

We evaluated the factorial validity and reliability of the Individuation Test for Emerging Adults–Short (ITEA–S) among Spanish ( n = 373) and Portuguese ( n = 351) emerging adults. Results of confirmatory factor analyses supported the original five-factor structure (Support Seeki...

From Transparency to Transport: Optoelectronic and Interfacial Signatures of n-Type ITO, FTO, ZnO and TiO2 Semiconductors

Transparent conducting oxides and electron transport layers are central to optoelectronic devices, yet their interfacial electronic behavior remains strongly dependent on substrate chemistry, defect states, and surface potential alignment. Here, we compare ITO and FTO transparent...

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic...