Universidade do Porto

Global and Local Approaches Applied to Mode I Fracture Toughness Measurement of Bi-Material Bonded Joints

Nowadays, the application of different materials is quite common to optimise the performance of structural components. In this context, bonding between metals and composites becomes a frequent strategy. However, the appropriate design requires special care owing to the complex st...

From immunity to jurisdictional territories: the evolution of cotos in the Kingdom of Galicia

In the Kingdom of León, cotos were spaces endowed with immunity by royal privilege. The Early Modern jurisdictional map reveals the major importance that cotos held in the territorial division of Galicia. Nevertheless, the surviving privileges of immunity are scarce, and many of...

Decoupling Neuroprotection from MAO Inhibition via Indane-to-Azaindane Bioisosteric Replacement of Rasagiline

Abstract Rasagiline is a monoamine oxidase B (MAO-B) inhibitor with neuroprotective effects, whose dependence on MAO-B inhibition remains unclear. Here, indane-to-azaindane rasagiline isosteres (rac-2a and rac-2b) were developed to investigate whether neuroprotection can be decou...

Integrating efficiency and effectiveness: A composite indicator approach to assess the performance of Federal Institutes of education

This study evaluates the performance of Brazilian Federal Institutes of Education through an integrated framework that jointly assesses efficiency and effectiveness. Efficiency is measured using Data Envelopment Analysis with a Directional Distance Function (DEA–DDF) combined wit...

Explainable machine learning for neurocognitive severity clustering and multivariable profiling after acute coronary syndrome

Neurocognitive impairment is a frequent complication of Acute Coronary Syndrome (ACS). Current research often treats cognitive decline as a monolithic outcome, failing to account for the heterogeneous ways in which psychosocial and clinical factors interact to form distinct patie...

Ultra-Stable Zinc Nitroprusside Cathode Operating at High Potentials for Inexpensive, Simpler-to-Scale Sodium-Ion Batteries

Abstract Driven by the demand for low-cost and environmentally sustainable energy storage technologies, sodium-ion batteries (NIBs) have emerged as a promising alternative to lithium-ion batteries. Among the various cathode candidates, Prussian blue analogs (PBAs) stand out due t...

Management of Acute Periodontal Conditions—The EFP S2k Level Clinical Practice Guideline

BACKGROUND: The European Federation of Periodontology (EFP) has developed Clinical Practice Guidelines (CPGs) for the treatment of periodontitis and for the management of peri-implant diseases. In accordance with the 2018 Classification, acute periodontal conditions are character...

Portuguese coaches’ and scouts’ perspectives on scouting processes in soccer: Psychological attributes and observation practices

Talent identification and development in soccer is a multifaceted process that requires the evaluation of players across a range of attributes. This study compared the perspectives of Portuguese coaches and scouts regarding scouting practices and examined their observation and ev...

Safety Climate Surveys, Maturity Models, and Triangulated Safety Culture Assessment: A Scoping Review of Diagnostic Methodologies

Safety culture has become a central construct in occupational safety management due to its recognized influence on organizational performance and accident prevention. However, the absence of a universally applicable assessment methodology has contributed to substantial methodolog...

Rehabilitation and the post-intensive care syndrome across the recovery continuum: a narrative review

Purpose Improved survival from critical illness has produced a growing population of intensive care unit (ICU) survivors with new or worsened physical, cognitive, and mental-health impairment, defined as post-intensive care syndrome (PICS), and frequent distress among families/ca...

Activation-independent capture of free fatty acids at the bacterial cell envelope by BrtB

ABSTRACT Fatty acids (FAs) are key metabolites in living organisms, shaping membrane architecture, and helping cellular acclimatization to changing conditions. Bacteria synthesize FAs de novo but can also reclaim them from membrane lipids or uptake them from the environment, usua...

First European Identification of a Partial Tacheng Tick Virus 8-like Underscores the Hidden Burden of Tick-Borne Flavivirus-like Viruses

Tick-associated viruses are an underexplored component of global viromes, and highly divergent RNA viruses often remain undetected due to low abundance and sequence divergence. Tacheng tick virus 8 (TcTV8) is a poorly characterized RNA flavivirus-like virus originally reported fr...

Using project management principles to plan the research and development project “Active Pregnancy”

Abstract This paper demonstrates how a principle-based interpretation of the Project Management Body of Knowledge (PMBoK) 8th Edition can enhance the initiating and planning phases of complex research projects, using a multicenter maternal health initiative—Active Pregnancy—as an...

Non‐contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor‐Associated Intracerebral Hemorrhage: An Analysis from ANNEXa ‐I Trial

In this post hoc analysis of the ANNEXa-I trial (n = 434), we evaluated non-contrast computed tomography (NCCT) markers of hematoma expansion (HE) in factor Xa inhibitor (FXai) -associated intracerebral hemorrhage (ICH). At least one NCCT marker was present in 72.1%, and HE (≥12....

Cross-sectional relationships between memory scores and neurodegeneration biomarkers in patients with suspected cognitive impairment

INTRODUCTION: We aimed to examine whether additional metrics derived from the CERAD Word List Memory Test (WLMT) such as acquisition patterns, error frequencies, and consolidation efficiency, are associated with cerebrospinal fluid (CSF) biomarkers of amyloid and tau pathology, a...

Clinical Outcomes of Patients Ineligible for Arteriovenous Vascular Access: A Retrospective Cohort Analysis

ABSTRACT Background A subset of patients with advanced chronic kidney disease (CKD) or kidney replacement therapy becomes ineligible for arteriovenous vascular access creation due to vascular exhaustion or comorbidity‐driven contraindications. Outcomes following a negative surgic...

Structure of the relationships between psychological and environmental variables in response to the climate crisis in Argentine and Spanish populations: a psychometric network analysis

Abstract The present study examined the relational structure between psychological and environmental variables associated with climate change: eco-anxiety, epistemic processes, coping strategies, psychological well-being, and pro-environmental behavior and assessed its stability...

Ecological and Quality Conditions for Children’s Participation as a Right in Early Childhood Education and Care

Abstract Providing space for children’s voices to be heard, listening to their ideas and giving due weight to their propositions, on all matters that affect them, describes the concept of participation rights according to the United Nations Convention of the Rights of the Child....

Volatile fatty acids permeation through nanofiltration and reverse osmosis membranes

Abstract This work presents a comprehensive experimental and modeling framework to describe and predict the volatile fatty acids (VFA) permeation in commercial polymeric nanofiltration (NF) and reverse osmosis (RO) membranes. The permeation behavior was evaluated using single‐ an...

Movement of European freshwater mussels under simulated dewatering conditions

Freshwater ecosystems are exposed to altered hydrological regimes due to climate change and poor water management, resulting in frequent and intense dewatering events. Freshwater mussels (Unionida) are particularly vulnerable to rapid water-level declines. Dewatering can lead to...