Universidade do Porto

Running-Related Injuries in Recreational Runners: Prevalence, Anatomical Distribution, and Associated Physiological and Training Factors

Background: Running-related injuries are a common issue among recreational runners and may affect training continuity and long-term participation. However, injury-associated factors remain unclear due to methodological heterogeneity and reliance on self-reported data. Objective:...

Preclinical Evaluation of Combined Polo-like Kinase 1 Inhibition and Navitoclax in Experimental Models of Lung Cancer

Targeted therapies have substantially advanced cancer treatment; however, therapeutic resistance remains a major challenge, particularly in lung cancer. Polo-like kinase 1 (PLK-1), a key regulator of mitosis, is frequently overexpressed in lung tumors and has emerged as an attrac...

Navigating Uncharted Waters: Steering the Course and Confronting Challenges of Brain Metastases in EGFR-Mutant Non-Small Cell Lung Cancer

Brain metastases represent a major clinical challenge in the management of non-small-cell lung cancer, particularly in patients with epidermal growth factor receptor mutations, constituting a leading cause of morbidity and mortality. In recent years, significant advancements have...

Recovery and characterization of a field derived Bagaza virus with broad cellular host range

Abstract Bagaza virus (BAGV) is an emerging orthoflavivirus that primarily infects wild birds, but its ability to infect other hosts remains poorly understood. We isolated infectious BAGV from the brain of a dead red-legged partridge by transfection of extracted viral RNA and eva...

Reconfiguring University Missions in the Knowledge Society: The Case of Portuguese Universities in European Alliances

ABSTRACT This paper examines how European Knowledge Society policy scripts, amplified by the European Universities initiative, are appropriated in the strategic plans of Portuguese public universities. Focusing on nine universities participating in European Universities Alliances...

Bivalve Gut Microbiome Responses to Sediment Characteristics and Anthropogenic Activities in Cerastoderma edule (Linnaeus, 1758)

Abstract Estuaries are dynamic ecosystems influenced by fluctuating environmental conditions and sediment-associated contamination, which may affect host-associated microbiomes. This study investigated the gut microbiome of the bivalve Cerastoderma edule across three estuarine si...

Effectiveness and Safety of a Self-Management Program for Substance Addiction Consequences: A Pilot Clinical Trial

Background: Harmful substance use affects millions of people, producing health and social consequences that require both professional support and effective self-management. This study piloted a self-management program targeting the consequences of substance addiction in adults en...

Validation of the DIVAS-Q (Day-to-Day Impact of Vulvovaginal Atrophic Symptoms Questionnaire): a Portuguese patient-reported outcome measure

Abstract Introduction Portuguese is the fifth most spoken language worldwide. However, no validated patient-reported outcome measure (PROM) is available to assess the impact of vulvovaginal atrophy (VVA) symptoms in Portuguese-speaking women. This study aimed to culturally adapt...

Measuring masses of transiting Earth-like planets: first insights from the PLATO RV Data Challenge

Abstract The PLATO Stellar Variability Mitigation Working Group designed a radial-velocity (RV) data challenge to assess the precision and accuracy achievable on RV semi-amplitudes in the context of the future PLATO follow-up. Using Sun-as-a-star observations obtained with HARPS-...

Do elite soccer players meet nutritional requirements? A scoping review and meta-analysis

This scoping review and meta-analysis synthesised current evidence on energy and macronutrient intake and energy expenditure in elite male and female soccer players. Despite established nutritional guidelines, concerns persist regarding chronic low energy availability and its imp...

A Multimodal Framework for Analyzing Engagement With Green Social Media Influencers

ABSTRACT In light of growing concerns about environmental degradation and unsustainable consumption patterns, effective communication about sustainability has become crucial in encouraging more environmentally conscious behavior. With their ability to connect with large audiences...

Active Screening for C. auris Colonisation: A Preventive Step or an Excessive Measure? A Systematic Review

Background: Patients’ and surfaces’ colonisation play a pivotal role in C. auris transmission. Understanding how, when, and where screening for colonisation should be done is important to control the spread. Methods: This systematic review searched studies regarding C. auris pati...

Trichlorination by a single cyanobacterial halogenase in the biosynthesis of lebomboamide A

Halogenation is a widely used strategy, both in nature and medicinal chemistry, to modulate the properties of small molecules. Cyanobacteria are a rich source of halogenases that act regio- and stereoselectively on sp3-hybridized carbon centers, which have been reported to cataly...

Impaction and Mineralization Status of the Mandibular Third Molar: A Retrospective Study

Chronological age estimation is used in legal contexts to determine the transition between minor and adult status, with the third molar (3M) being a primary biological indicator. This retrospective study aimed to analyze the relationship between the topographic position of impact...

Exploring the relation between childhood adversity and diabetes medication adherence: a cross-sectional study

Adverse Childhood Experiences (ACE) are associated with poor health outcomes, but their effect on the medication adherence of patients with type 2 diabetes (T2DM) remains unclear. This study aimed to assess the relation between ACE and medication adherence, while also exploring w...

From Petro-Polymers to Biopolymers: Chitosan Strategies for Sustainable Hemodialysis

Hemodialysis (HD) remains the most widely adopted renal replacement therapy for patients with end-stage kidney disease; however, its delivery entails a substantial environmental burden due to high water and energy consumption and extensive reliance on single-use synthetic polymer...

Real-World Safety Profile of Adjuvant Abemaciclib in HR+/HER2− Early Breast Cancer

Background/Objectives: Treatment with adjuvant abemaciclib plus endocrine therapy (ET) has been demonstrated to improve outcomes in patients with HR+/HER2- early breast cancer at high risk of recurrence. However, real-world data regarding abemaciclib tolerability and treatment ma...

How ageism shapes gerontogeriatric competencies in newly graduated nurses: A cross-sectional analysis

This cross-sectional study examined the association between ageism and self-perceived gerontogeriatric competence among newly graduated registered nurses (NGRNs). A total of 242 NGRNs completed an online questionnaire that included the Ambivalent Ageism Scale (AAS) and the Geront...

Primary prevention of child sexual abuse with preschool children in Portugal: A pilot feasibility trial of the CARE program

Background Child sexual abuse (CSA) is a major public health concern, yet rigorously evaluated and fully manualized primary prevention programs for preschool children remain scarce. Evidence on the feasibility and acceptability of such interventions among young children and their...

Terminology for describing the 24-h cycle of physical activity, sedentary behaviour, and sleep: a scoping review

Abstract Background Physical activity, sedentary behaviour, and sleep are three behaviours which occupy the 24-h cycle and interact to influence a multitude of health outcomes. Different terms are currently used to describe these behaviours collectively (e.g., movement behaviours...