Universidade de São Paulo

A comparative evaluation of outlier detection in categorical and mixed data

Outlier detection is essential in different domains such as cybersecurity and fraud detection, to name a few. However, identifying the best way to detect outliers is often a challenge. Although most algorithms are designed for numerical data, many real-world datasets contain cate...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Routine versus clinically indicated cerebrospinal fluid sampling for infection in external ventricular drains: a systematic review

BACKGROUND: External ventricular drains (EVDs) are commonly used in neurosurgery but carry a risk of ventriculostomy-related infection. Routine cerebrospinal fluid (CSF) sampling is commonly performed for surveillance, although its clinical value and potential risks are still unc...

Two new species of Ziminellia Nihei & de Carvalho from China (Diptera: Muscidae), with new combinations and key to species

During our study of the genus Ziminellia (Diptera, Muscidae) from China, two species are recognized as new to science, Z. quadrangula Xue & Nihei, sp. nov. and Z. yunnanensis Xue & Zhang, sp. nov., and their descriptions, illustration and diagnoses are given. Furthermore, five ne...

Annotated Catalog of Vespid Hosts (Hymenoptera: Vespidae) of Tachinidae (Diptera), with Description of a New Species of Ophirion Townsend from Brazil

species may be a suitable model to understand how tachinids were able to explore eusocial vespid hosts.

Redefining Last Glacial Maximum environmental conditions in northeastern Brazil: pollen-based evidence of open and moist-adapted vegetation cover

Limited continuous continental records and complex climatic interactions hinder a comprehensive understanding of paleoclimatic and paleoenvironmental conditions during the Last Glacial Maximum (LGM) in the tropics. Adjacent to the currently semi-arid northeastern Brazil (NEB), a...

Familial florid cemento-osseous dysplasia in two young sisters: case report and literature review

Recently identified as a variant of cemento-osseous dysplasia, familial florid cemento-osseous dysplasia (FFCOD) differs from the sporadic florid variant in both clinical and radiographic behaviour and has an autosomal dominant inheritance pattern. The aim of this study is to des...

Context-Dependent modulation of astrocytic Ca2+ signals by mitochondria: a computational study

Abstract Mitochondria regulate intracellular Ca 2+ by uptake through the mitochondrial Ca 2+ uniporter (MCU) and release via the mitochondrial permeability transition pore (mPTP). In astrocytes, neurotransmitter stimulation evokes Ca 2+ signaling, yet the role of mitochondria in...

Autologous hematopoietic stem cell transplantation modulates epidermal-related inflammation/fibrosis mechanisms in systemic sclerosis patients

Abstract Background Autologous hematopoietic stem cell transplantation (auto-HSCT) has been shown to reduce cutaneous fibrosis and change dermal architecture in skin of systemic sclerosis (SSc) patients. However, its impact on the epidermis remains underexplored. Here, we examine...

Type 2 Angiotensin II receptor (AT2R) deficiency exacerbates cardiac senescence and fibrosis in aging mice

Cardiac aging increases susceptibility to cardiovascular diseases. Cellular senescence may be involved in the development of age-related cardiac diseases. Extensive evidence derived from both clinical and experimental studies suggest that the Type 2 Angiotensin II receptor (AT2R)...

Binary Compression and Interscale Operators on Primorial Wheels

Description This publication investigates the single scale transition (from modulus M to qM) in wheel sieves from a discrete dynamical systems perspective [1, 3]. Rather than focusing on prime-generation algorithms, the study analyzes the exact information content preserved or di...

Environmental performance of hydrogen production via eucalyptus biomass gasification and natural gas steam reforming: A life cycle assessment approach

A life cycle assessment (LCA) was conducted to compare hydrogen production via steam methane reforming (SMR) of natural gas and eucalyptus biomass gasification under Brazilian conditions. Three scenarios were evaluated for the production of 1 kg of hydrogen: (i) SMR, (ii) SMR wit...

Bisexual population of the parthenogenetic tick Amblyomma rotundatum: bioecological data from the field and laboratory

The tick Amblyomma rotundatum parasitizes primarily cold-blooded animals and is widely distributed in the Neotropics. This tick is considered parthenogenetic, with rare reports of males in nature. In the present study, we identified for the first time a bisexual population of A....

Agro-Industrial Coproducts as Sustainable Substrates for Colorant Biosynthesis by Talaromyces sp.

Natural colorants derived from filamentous fungi have gained increasing attention as safe, sustainable, and bioactive alternatives to synthetic counterparts. This study evaluated the red colorant production by Talaromyces sp. under solid and static submerged culture conditions, f...

Environmental monitoring of soil carbon and ecosystem productivity across land use systems in the Atlantic Forest of Brazil

Abstract Tropical ecosystems play a fundamental role in the global carbon cycle due to their high productivity and capacity to store carbon in vegetation and soils. However, land use change has substantially altered these processes, particularly in highly fragmented regions such...

Oral frailty and bite force in physically active older adults: functional insights into healthy aging

Abstract Background Oral frailty is associated with adverse health outcomes in the elderly. Bite force has been proposed as a functional indicator of oral and systemic decline. Methods A cross-sectional study was conducted with 500 physically active older adults living in the com...

Homogeneous Ethanol CuCl 2 /TMEDA/TEMPO System Mimicking Laccase/TEMPO for the Catalytic Aerobic Oxidation of Primary Furyl, Allyl and Benzyl Alcohols

ABSTRACT We report herein a homogeneous ethanol CuCl 2 /TMEDA/TEMPO system for the catalytic aerobic oxidation of primary furyl, allyl, and benzyl alcohols. Under the established protocol, the reactions occur under mild conditions (25°C, open‐air atmosphere), requiring low cataly...

Meta-analysis of NPC2-mediated cholesterol transport in human cancers as a prognostic biomarker with therapeutic implications

NPC2 is a lysosomal cholesterol transporter involved in intracellular lipid trafficking and cholesterol homeostasis, processes that have been increasingly implicated in cancer biology. To quantify the clinical impact of NPC2 expression across human malignancies, we analyzed survi...

Computational Methods in Physical Virology: A Critical Perspective across lengths and timescales

Physical virology investigates viral particles by focusing on their assembly, stability, mechanics, and interactions with host cells, neutralizing antibodies, and surfaces. Within this field, computational virology is becoming an indispensable pillar, serving as a "computational...

Healthcare occupancy data as an early warning indicator of infectious disease surges in São Paulo

Early detection of infectious disease surges is critical for effective public health response, yet traditional surveillance systems often suffer from delayed reporting. Here, we investigate whether passively collected occupancy data from healthcare facilities can act as an early...