Universidade de São Paulo

Hybrid Sequential Meniscal Suture Technique

Abstract Meniscal preservation is a priority in the treatment of knee injuries because of the fundamental role of the meniscus in load absorption, joint stability, and chondral protection. Several repair techniques have been described, including inside‐out, outside‐in, and all‐in...

Enzymatic confinement in lipidic mesophases and liquid-crystalline nanoparticles: from nanostructure to biocatalytic function

Abstract Lipidic liquid-crystalline mesophases and their dispersed counterparts, lipid liquid-crystalline nanoparticles (LCNPs), constitute highly organized soft nanostructured materials that can accommodate biomolecules within both interconnected aqueous channels and lipid bilay...

Adhesive-based protective strategies for enamel cracks during in-office bleaching and their effect on hydrogen peroxide penetration

Abstract Objectives To evaluate hydrogen peroxide (HP) penetration in teeth with enamel cracks and to investigate if adhesive-based strategies can reduce its permeability without compromising bleaching efficacy (BE). Materials and methods Fifty human premolars ( n = 10 per group)...

Adjunctive mild controlled hypothermia for moderate necrotizing enterocolitis in very low birth weight infants: a prospective cohort study with external contemporaneous controls

Abstract Necrotizing enterocolitis (NEC) is a severe condition in preterm infants. Few therapies are available to slow disease progression or reduce the need for surgery. This study aims to assess if mild controlled hypothermia as an adjunctive treatment reduces surgical interven...

Changing the world from Latin America: Milton Santos between transnational networking and multilingual worldings

On the occasion of the centenary of the birth of Brazilian radical geographer Milton Santos (1926–2001), we publish here for the first time the text of a guest lecture that he gave at the Fourth Meeting of Latin American Geographers (EGAL) in Mérida, Venezuela, in 1993. Unusually...

Characterization of an EPS-Enriched Emulsifying Extracellular Fraction Produced by a Brazilian Strain of Vreelandella zhaodongensis

Microbial exopolysaccharides (EPS) are structurally diverse biopolymers with ecological and biotechnological relevance due to their physicochemical and functional properties, including emulsification, metal chelation, and contributions to biofilm formation. In this study, an EPS-...

Comparative Effectiveness Research in the Americas on Penetrating Brain Injury: The COMPAS-PBI Study Protocol.

BACKGROUND AND OBJECTIVES: Penetrating brain injury (PBI) is a highly lethal form of traumatic brain injury, with substantial mortality and marked differences across high-income countries and low- to middle-income countries. The aim of the Comparative Effectiveness Research in th...

Sport-Specific Assessment for Change of Direction Ability in Taekwondo: A Brief Review with Guidelines for Testing

In taekwondo combat, agility is essential for rapid movement and maintaining match pace, as well as for executing unilateral technical actions swiftly in multidirectional planes. Furthermore, it is also required to dodge and block opponents’ repeated attacks and to handle clinch...

The first annotated checklist of the bees of Colombia reveals an overlooked diversity and areas with major data deficiencies

Background Most existing knowledge about bee biodiversity comes from temperate regions, where diversity is presumed highest—yet substantial data gaps across the tropics confound this pattern. Checklists are critical for documenting species presence, identifying knowledge gaps, an...

Field sampling guidelines for sedimentary ancient DNA (sedaDNA) research in lacustrine and coastal systems: from field collection to laboratory subsampling

Abstract Sedimentary ancient DNA (sedaDNA) has emerged as a powerful proxy for reconstructing past biodiversity and environmental change in lacustrine and coastal systems, yet standardized field guidance remains limited, particularly for researchers working in tropical and coasta...

PS4-21. Serum Metabolomic Changes Induced by Guanidinoacetic Acid Supplementation in Growing Nellore Cattle.

Abstract Guanidinoacetic acid (GAA) is a fundamental precursor of creatine, and its role in muscle energy metabolism is of potential importance in growing cattle. The objective was to evaluate blood metabolic changes induced by GAA supplementation in Nellore cattle during the gro...

Phage heteroresistance in clinical Klebsiella pneumoniae isolates: impact of differentiated capsule expression on phage efficacy

Abstract Heteroresistance, commonly described in the context of antibiotics, refers to the presence of resistant subpopulations within a bacterial strain, and is recognized as a likely contributor to treatment failure. Whether population heterogeneity affects phage activity remai...

Temporal and conceptual variability of chart datum based on harmonic constants: a case study for Ilha Fiscal

Abstract This study evaluates chart datum (CD) variability considering sea-level record length and the datum concept adopted. A 1989–2021 tide-gauge record from Ilha Fiscal, Rio de Janeiro, was analysed using multiple series and three CD concepts: approximately Mean Low Water Spr...

Genomic features of mecA-harboring Staphylococcus epidermidis infecting an illegally traded rufous-bellied thrush (T. rufiventris)

Abstract Staphylococcus epidermidis is an opportunistic bacterium frequently involved in healthcare-associated infections and has become increasingly relevant in One Health when associated with methicillin resistance profile. Despite its significance in human medicine, the circul...

Nuclear proteome analysis suggests spatial and temporal compartmentalization of metabolic enzymes during Trypanosoma cruzi cell cycle

Trypanosoma cruzi , the etiological agent of Chagas Disease (CD), represents a significant public health concern and serves as a valuable model for investigating the cell cycle in early-diverging eukaryotes. Its unique cellular features,including the absence of chromosome condens...

Longitudinal outcomes of auditory and spoken language skills following unilateral and bilateral cochlear implantation in children and young adults with inner ear malformations

ABSTRACT Introduction Severe-to-profound sensorineural hearing loss significantly impairs spoken language acquisition and cognitive development. Cochlear implants (CIs) bypass damaged inner ear structures to directly stimulate the cochlear nerve and represent an effective rehabil...

Body Weight in Relation to the Effectiveness of Intravenous Alteplase in Acute Ischemic Stroke: The ENCHANTED Trial

BACKGROUND: The prognostic significance of body weight in patients receiving thrombolysis for acute ischemic stroke remains uncertain. This study aimed to determine whether body weight modifies the comparative effects of low- versus standard-dose intravenous alteplase and to eval...

Impulsive Release Strategies for Wolbachia-Infected Mosquitoes Under Temperature-Induced Infection Loss

Abstract The release of Wolbachia -infected mosquitoes is a promising strategy for controlling Aedes aegypti populations, although high-temperature exposure may temporarily reduce infection levels and compromise long-term persistence. We propose a population-dynamics model based...

Multimodal Magnetic Resonance Imaging and Machine Learning Uncovers Distinct Progression Patterns in Friedreich Ataxia

Abstract Background Friedreich ataxia (FRDA) is a rare neurodegenerative disorder with heterogenous clinical progression, complicating prognosis and trial design. Neuroimaging offers objective biomarkers of disease progression, yet variability in progression patterns remains poor...

Absolute Primary Nanothermometry Using Individual Stark Sublevels of Rare-Earth-Doped Crystals

Abstract We present two independent optical methods for absolute primary thermometry using rare-earth-doped nanoparticles. Both approaches rely exclusively on the internal energy levels and population dynamics of the dopant ions, eliminating the need for external temperature refe...