Universidade de São Paulo

Proteoglycans and Biomineralization of Bone and Dentin

Although many advances have been made during the last six decades, the controlled processes by which vertebrate hard tissues acquire, organize, and maintain their mineral component remain only partially understood. Mineralized tissues can be classified into two categories based o...

Real-Time Leader-Follower UGV-UAV Cooperation: Experimental Validation and Control Analysis

Abstract This paper presents the experimental validation of a real-time leader–follower cooperative control architecture for a heterogeneous system composed of a differential-drive Unmanned Ground Vehicle (UGV) and a quadrotor Unmanned Aerial Vehicle (UAV). In the proposed framew...

Human Macrophage Polarization Dynamics on a 3D Fibrous Polydioxanone Mesh In Vitro

The host immune response plays a central role in determining biomaterial performance, particularly through early macrophage activation dynamics at the tissue–biomaterial interface. This study evaluated the response of THP-1-derived human macrophages cultured on a fibrous extracel...

Multiscale characterization of cortical signatures in positive and negative schizotypy:a worldwide ENIGMA study

Positive and negative schizotypy reflect distinct patterns of subclinical traits in the general population associated with neurodevelopmental and schizophrenia-spectrum pathologies. Yet, a comprehensive characterization of the unique and shared neuroanatomical signatures of these...

Machine Learning for Early Detection of Preeclampsia and Gestational Diabetes from Routine Clinical Data and Paternal Immunological Proxies: A Systematic Literature Review

Systematic literature review (PROSPERO CRD420251061201) of machine-learning prediction models for preeclampsia (PE) and gestational diabetes (GDM) using routinely collected clinical data, with paternal and partner variables as a primary analytic axis. 446 studies were screened ac...

Diagenetic Constraints and Impact of Silicification on the Quality of Pre‐Salt Reservoirs of the Sépia Field, Santos Basin, Brazil: Insights From Oxygen Isotopes and Fluid Inclusions

ABSTRACT The conditions and role of silicification in the giant South Atlantic pre‐salt reservoirs have been widely debated recently. Many studies link silicification with degraded reservoir quality, whereas others associate it with increased permeability. Predicting the occurren...

Twisted Steinberg algebras, regular inclusions and induction

Given a field \mathbb{K} and an ample (not necessarily Hausdorff) groupoid G , we define the concept of a line bundle over G inspired by the well-known concept from the theory of C*-algebras. If E is such a line bundle, we construct the associated twisted Steinberg algebra in ter...

Synthesis and self-assembly of amphiphilic thermoresponsive PNIPAAm-b-PHBHV-b-PNIPAAm triblock copolymers via RAFT polymerization

Abstract The design of amphiphilic thermoresponsive block copolymers enables the development of nanostructured systems for controlled drug delivery. In this context, we report the synthesis of a well-defined triblock copolymer, poly( N -isopropylacrylamide)- b -poly(3-hydroxybuty...

Antimicrobial Resistance, Metal Tolerance, and Virulence Determinants in Gram-negative Opportunistic Pathogens Isolated from Brazilian Groundwater

Abstract Groundwater is a critical freshwater resource, but its quality can be compromised by anthropogenic contamination. Metals may exert selective pressure on microbial communities, promoting metal-tolerant bacteria carrying metal tolerance genes (MTGs), which are often associ...

Lack of Efficacy of Low‐Dose Cyclobenzaprine on Electromyographic Activity Related to Sleep Bruxism: A Randomized Crossover Double‐Blind Placebo‐Controlled Clinical Trial

Sleep bruxism (SB) is a motor activity characterized by repetitive masticatory muscle contractions during sleep, commonly associated with tooth damage and jaw pain or headache. Pharmacological management strategies targeting its central nervous system-related mechanisms remain li...

Microplastic and nanoplastic interactions with per- and polyfluoroalkyl substances (PFAS) in soils: a critical review of main findings and knowledge gaps

Abstract Microplastics (MPs), nanoplastics (NPs), and per- and polyfluoroalkyl substances (PFAS) can enter soils through biosolids, compost, landfill leachate, reclaimed-water irrigation, treated textiles, and industrial releases. However, whether plastic particles modify PFAS fa...

Differential Effects of Cannabidiol and Cannabigerol on Cognition, Neuroinflammation, and Blood–Brain Barrier Integrity in a Rat Model of Iron Overload

Abstract Iron is an essential micronutrient for brain development, participating in mitochondrial respiration, myelination, and neurotransmitter synthesis. However, previous studies have demonstrated that excessive iron during early postnatal life induces oxidative reactions, lea...

Effectiveness of COVID-19 vaccination schedules against severe COVID-19 in children aged 6 months to 4 years in Brazil: A population-based cohort study (2023–2024)

ABSTRACT Background Although the impact of COVID-19 vaccination is widely documented in the general population, the evidence on its effectiveness in children under 5 years of age is still limited. In this context, the continuation of vaccination programs in this age group has bee...

Dams trigger long-term river-floodplain decoupling in dynamic Andean foreland rivers

Andean foreland rivers are preferential sites for ongoing and planned hydroelectric dam construction in the Amazon Basin. These rivers are characterized by high sediment fluxes that drive rapid rates of channel migration, large river-floodplain sediment exchanges, and creatediver...

The effect of the respiratory rate on mechanical power and patient outcomes – a systematic review

INTRODUCTION: Mechanical power (MP) is associated with worse clinical outcomes. Respiratory rate (RR) is a key component of MP. The aim of this systematic review was to assess whether, among mechanically ventilated adult ICU patients, a low versus high RR is associated with diffe...

The AWAKEN wind farm benchmark – Part 2: Modeling results

Abstract. Accurately modeling wind farm performance in complex atmospheric flows remains a challenge. This paper presents the modeling results of the American WAKE experimeNt (AWAKEN) wind farm benchmark, a collaborative effort involving 16 research groups from academia and indus...

Modified Citrus Pectin-Mediated Gal-3 Reduction Attenuates Metabolic Dysfunction-Associated Steatohepatitis in an Experimental Model

Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by hepatic steatosis, inflammation, fibrosis, and metabolic dysfunction, with limited therapeutic options currently available. This study investigated whether pharmacological inhibition of Galectin-3 (Gal-3)...

Feeding regime alters mitochondrial metabolism in beef skeletal muscle

Abstract Plane of nutrition influences animal growth rate and muscle fiber composition, potentially through altering skeletal muscle metabolism. The objective of this study was to evaluate changes in skeletal muscle metabolism in response to altering diet without changes in growt...

War, climate change, and mental health: a geopsychiatric perspective on an emerging global polycrisis

Abstract Background War, armed conflict, forced displacement, and climate change are increasingly interconnected determinants of mental health. A geopsychiatric perspective situates their effects within the interacting geographic, geopolitical, environmental, cultural, economic,...

Circulating Matrix Metalloproteinase Activity and Functional Capacity in Individuals Undergoing Hemodialysis: Exploratory Findings from a Resistance Training Trial

Abstract Purpose To investigate the effects of 24 weeks of resistance training (RT) on pro- and active matrix metalloproteinases (MMPs) and their association with functional performance in end-stage kidney disease (ESKD) patients undergoing hemodialysis. Methods Forty-two ESKD pa...