Universidade de São Paulo

Functional neurological disorder: characterization, diagnosis, and outcome predictors in a Brazilian cohort

Abstract Functional neurological disorder (FND) is a prevalent, disabling neuropsychiatric condition recognized as a distinct clinical entity characterized by positive neurological signs. Despite growing international research, Brazilian data on this disoder remain scarce and pre...

Systems biology analysis reveals miRNA–mRNA networks associated with cardiomyocyte responses to SARS-CoV-2 infection

Cardiac complications are common and clinically significant in COVID-19, yet their underlying molecular drivers remain poorly understood. Here, we integrate post-mortem histopathology with transcriptomic and microRNA (miRNA) analyses to delineate the regulatory architecture of SA...

Common genetic mechanisms between obesity and COVID-19 severity: unravelling pleiotropic loci and biological pathways

Abstract COVID-19 and obesity are complex conditions marked by immune and metabolic dysfunction, with the former still ranking among the leading causes of death from infectious diseases worldwide and the latter reaching pandemic proportions. Clinical evidence consistently shows t...

A Hybrid Lifestyle Program and Metabolic Health in Adults With Obesity

Importance: Obesity disproportionately affects low- and middle-income countries, where access to structured, scalable treatment remains limited. Objective: To evaluate whether a hybrid-format, intensive lifestyle modification program combined with usual medical care promotes a mi...

Non-functional capillary modulates the honeymoon period in congenital diaphragmatic hernia

Congenital diaphragmatic hernia (CDH) results in lung hypoplasia and vascular remodeling with persistent pulmonary hypertension with significant mortality and morbidity. While only the analysis of the ‘’functional’’ gas-exchange capillary with diverging findings has been publishe...

Taxonomic delineation of four Zygophyllum simplex L. (Zygophyllaceae) morphotypes using morphoanatomical, molecular (SCoT) and chemotaxonomic evidence

Abstract Background This study presents a comprehensive taxonomic adjustment of Zygophyllum simplex (L.) four constituent varieties in Egypt, integrating morphological, anatomical, palynological, molecular, and phytochemical analyses to evaluate their infraspecific differentiatio...

Revisiting the Fragmentation of Ketoconazole by Positive Electrospray Ionization Tandem Mass Spectrometry and Density Functional Theory Calculations

ABSTRACT Rationale Ketoconazole (KCZ) is a clinically essential antifungal and potent CYP3A4 inhibitor. Its gas‐phase fragmentation under positive electrospray ionization tandem mass spectrometry (ESI‐MS/MS) remains poorly characterized, undermining metabolite profiling and struc...

Simultaneous Voltammetric Determination of Neurodegenerative Biomarkers at Nanomolar Levels Using a Fe3O4 Nanoparticle-Decorated Glassy Carbon Microsphere Nanocomposite

Abstract The precise monitoring of dopamine (DA), serotonin (5-HT), and L-tryptophan (L-Trp) is a critical challenge for the early diagnosis and management of neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases. This work describes the development of a high-...

Burkholderia lata BL02 Galactolipase as an Important Biocatalyst for Plant Biomass Deconstruction and Sugar Ester Synthesis

The transition toward sustainable biorefinery processes requires efficient strategies for lignocellulosic biomass deconstruction and valorization. In this study, an integrated enzymatic system combining fungal holocellulases and laccases with a bacterial galactolipase was develop...

Segurança e efetividade de diferentes modelos de interfaces para suporte de ventilação não invasiva para recém-nascidos pretermo com idade gestacional maior- igual 28 semanas

Informações do Projeto de PesquisaAutor: André Luis Bispo Neves | Orientadora: Prof.ª Dr.ª Cintia JohnstonInstituição: Faculdade de Medicina da Universidade de São Paulo (FMUSP)Local de Execução: UTIN do Hospital Inácia Pinto dos Santos (Feira de Santana - BA) | Período: 2025 – 2...

Effects of Antimitotic Agents, Temperature and Immersion Time on Chromosome Doubling Efficiency in Supersweet Corn ( Zea mays L . var. saccharata )

ABSTRACT Doubled haploid technology accelerates the development of fully homozygous maize lines compared with conventional selfing. However, specific protocols for supersweet corn ( Zea mays L . var. saccharata ), particularly regarding immersion time in antimitotic solutions and...

Advancing to Chromosome-Scale Genome Assembly of a Cunninghamella blakesleeana Strain: A Potential Biocontrol Agent of Cupuaçu Tree Witches’ Broom Disease

Here, we present the first complete chromosome-scale genome assembly of a Brazilian Cunninghamella blakesleeana strain UFAC-CB2.1. We combined Nanopore long reads with high-quality Illumina paired-end reads to produce a final assembly comprising eight chromosomes (seven nuclear a...

Endovascular therapy versus best medical treatment in pediatric acute ischemic stroke: A systematic review and meta-analysis

Purpose This systematic review and meta-analysis evaluates endovascular therapy (EVT) versus best medical treatment (BMT) in pediatric acute ischemic stroke (AIS) due to large-vessel occlusion. Methods Systematic searches were conducted across PubMed, Cochrane, and Embase, incept...

Direct-Write Laser-InducedGraphene Microstrip PatchAntennas on Medium-Density Fiberboard

Abstract Laser-induced graphene (LIG) has been used in flexible and wearable antennas fabricated on polymeric substrates and paper; however, these materials are not ideal for seamless integration into rigid indoor structures. Antennas integrated into such structures would represe...

On the effects of using nonlinear springs in mono-coupled periodic structures

Abstract Many strategies are employed to control structural vibration. One of them is to design structural elements in a periodic arrangement to obtain the so-called bandgap effect. For infinite periodic structures, bandgaps are defined as frequency ranges where waves do not prop...

Effects of different volumes of a water-soluble and biodegradable nesting material on behavior, pain, glycemia, farrowing traits, and performance in crated sows

Abstract This study evaluated the effects of providing 3–15 kg of a soluble and biodegradable biopolymer-based enrichment material (blend of biodegradable polymers and natural fibers) to prepartum sows housed in farrowing crates. Fifteen sows were blocked by body weight and backf...

Single and MultipleInfestation by Coccoid Pests inCoffee Shape Plant Chemical Defenses and Interactions Across TrophicLevels

Abstract Crop plants are attacked by multiple pests, inducing metabolic changes that shape interactions across trophic levels and influence the effectiveness of biological control. We examined how infestation by the coccoids Coccus viridis (scales) and Planococcus citri (mealybug...

Ferdinandea Island and Graham Bank, Sicily Channel: An Integrated Historical, Geological and Geomorphological Synthesis of a Shallow Submarine Monogenetic Volcanic Field

Ferdinandea Island, part of a shallow-water submarine volcanic field, emerged in the Sicily Channel between Italy and Tunisia in July 1831 and was eroded below sea level within months; its submerged remnant forms the shallowest water depth region of Graham Bank. Here, we review n...

Longitudinal Changes in Work-Related Pleasure, Suffering, and Harm Among Healthcare Workers During the COVID-19 Pandemic

Healthcare workers experienced substantial psychosocial challenges during the coronavirus disease 2019 (COVID-19) pandemic, yet longitudinal evidence on changes in work-related pleasure, suffering, and harm remains limited. This study investigated longitudinal changes in psychoso...

Color Symmetry Breaking in a Nonlinear Optical Microresonator

ABSTRACT Spontaneous symmetry breaking leads to diverse phenomena across the natural sciences, from the Higgs mechanism in particle physics to superconductors and collective animal behavior. In photonic systems, the symmetry of light states can be broken when two optical fields i...