Universidade de São Paulo

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Food insecurity in individuals living with cancer: a systematic review of prevalence, social determinants, and health outcomes

Abstract Aim This systematic review aims to investigate the association between food insecurity (FI) and quality of life, prognosis, survival, and treatment-related outcomes in adult cancer patients. Methods A comprehensive search was conducted in MEDLINE (PubMed), Embase, and CI...

Long-term immunological impairment after early thymectomy in congenital heart disease

Abstract Early thymectomy during congenital heart disease repair may impair thymic output, but long-term effects across age groups remain incompletely defined. We evaluated T-cell receptor excision circles (TRECs) and a comprehensive panel of lymphocyte subsets in 20 adults (mean...

Spatial distribution and spatiotemporal clustering of AIDS notifications among men in Brazil, 2014–2023: an ecological study

This study aimed to analyse the spatial distribution and spatiotemporal clustering of AIDS notifications among men in all 5570 Brazilian municipalities between 2014 and 2023. Using an ecological design, data on AIDS notifications among men (≥ 13 years) were retrieved from Brazil’...

Multidisciplinary Support for Children With Genodermatoses in Brazil: A RE ‐ AIM Evaluation of Casa Santa Teresinha's Community‐Based Model

ABSTRACT Genodermatoses impose substantial psychosocial and functional burdens on affected children and their families, yet structured community‐based support models remain underrepresented in the literature. We describe Casa Santa Teresinha , a Brazilian non‐profit organization...

Temporal trends in congenital syphilis incidence per 1000 live births in the Americas

Congenital syphilis (CS) is a significant infectious condition associated with a high social and economic burden. In the Americas, the epidemiological situation remains concerning, with varying patterns across countries. Our study evaluated temporal trends in CS incidence per 100...

Characterization and Nanoparticle Immobilization of a Thermotogaceae Esterase Active on Aromatic and Aliphatic Esters

Abstract Esterases are a class of enzymes that catalyze the hydrolysis of carboxylic ester bonds and are widely utilized in the food, pharmaceutical, and detergent industries. In this study, we report the identification and comprehensive characterization of a novel esterase (TbEs...

Infection of macrophages by mpox virus activates inflammasome and cell death, informing multitarget therapeutic strategies

Severe mpox virus (MPXV) infection causes immunopathological manifestations in patients. Here, we provide clinical evidence of MPXV-induced inflammation in a large patient cohort and demonstrate direct macrophage infection in skin tissues from an autopsied mpox patient. In human...

Differential associations between treatment delay and survival across head and neck cancer subsites: a national hospital-based framework for risk-stratified prioritization

Purpose Delays in time to treatment initiation (TTI) have been associated with inferior outcomes in head and neck cancer, yet prior studies have typically evaluated tumors collectively, assuming uniform time sensitivity across diseases. This study quantified subsite- and stage-sp...

Impact of grid resolution on the abyssal ocean representation in numerical models

Accurately representing abyssal water masses and their inter-basin pathways remains a challenge for global ocean models and reanalyses. In this study, we investigate how horizontal and vertical resolution influence the simulation of abyssal waters by first evaluating three ocean...

Light stimuli attenuates inflammatory activation in primary bone marrow-derived macrophages

Abstract Bone repair depends on a regulated macrophage-driven inflammatory response. Non-activated macrophages (M0) differentiate into pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes in response to microenvironmental signals. This study evaluated, in vitro, the effects...

Soil-plant-animal properties and microbial reassembly distinguish cattle oral disease prevalence across converted Amazon pasture systems

Forest-to-pasture conversion can alter soil properties, forage composition, and microbial communities, but whether these changes are associated with bovine periodontitis remains unclear. We compared eight pasture systems in the Western Brazilian Amazon classified by high or low h...

Flow cytometry as a tool for assessing reactive oxygen species-related fluorescence in peripheral blood leukocytes from children and adolescents with asthma

Background Asthma is characterized by airway inflammation and bronchial hyperreactivity, with increased production of reactive oxygen species (ROS). Assessing oxidative stress is relevant to disease pathophysiology, but many methods have limitations in pediatric populations . Obj...

Cutaneous Lymphoma International Prognostic Index and Risk Stratification in Advanced Mycosis Fungoides and Sézary Syndrome

Importance Risk stratification in advanced mycosis fungoides and Sézary syndrome (MF/SS) remains suboptimal given that current TNMB (tumor, node, metastasis, blood) staging has limited prognostic value for clinically relevant outcomes. Objective To determine whether the Cutaneous...

Sorption, desorption, and leaching of S-metolachlor in two soils amended with maize stover

S-metolachlor is widely used across various crops for its effectiveness as a grass herbicide and is considered pivotal, particularly amidst multiple cases of resistance in weed biotypes of the Poaceae family. In no-till systems, the presence of surface residues can modify herbici...

Repurposing the Insecticide Flufenerim, the Only Anti- Cryptococcus Compound Identified in the MMV Global Health Priority Box, as a Candidate for the Environmental Control of the Cryptococcosis Agents

Abstract Cryptococcus neoformans and Cryptococcus gattii are environmental fungi that cause cryptococcosis, a severe, life-threatening infection, particularly in immunocompromised individuals. Current treatments are limited by toxicity, restricted availability, and the emergence...

Measuring the Azorean blue economy: a value chain approach

Economic activities associated with marine and coastal resources – commonly referred to as the blue economy – play a central role in coastal regions such as Portugal. Despite the Azores' small population and structural constraints, the blue economy holds significant potential for...

Protein engineering in Brazil: a biophysical perspective

Abstract Protein engineering has become an increasingly interdisciplinary field, integrating molecular biology, structural biology, biophysics, computational modeling, and artificial intelligence to modify protein structure, stability, dynamics, molecular recognition, and catalyt...

Divergent Diagrams of Folds Associated with Reflections

Abstract We analyze divergent diagrams of k -fold map-germs at $$(\mathbb {C}^n,0)$$ ( C n , 0 ) , for $$k, n \ge 2,$$ k , n ≥ 2 , associated with reflections, adapting to the complex setting the theory of folds associated with involutions at $$(\mathbb {R}^n,0)$$ ( R n , 0 ) . I...

Hybrid Sequential Meniscal Suture Technique

Abstract Meniscal preservation is a priority in the treatment of knee injuries because of the fundamental role of the meniscus in load absorption, joint stability, and chondral protection. Several repair techniques have been described, including inside‐out, outside‐in, and all‐in...