Universidade de São Paulo

Cognitive Effort as a Compensatory Mechanism for Motor Control in Impulsivity

Impulsivity, although commonly associated with maladaptive behavior, can influence how individuals manage cognitive and motor demands. This study analyzed the effect of impulsivity on motor control and cognitive effort during manual aiming tasks that varied in cognitive load. Fro...

Outcomes of patients with adult T-cell leukemia/lymphoma at a university and a public cancer center in Brazil

OBJECTIVE: This study aimed to characterize adult T-cell leukemia/lymphoma (ATLL) cases in Brazil, a human T-cell lymphotropic virus type 1 (HTLV-1) endemic country, focusing on clinical presentation, diagnostic patterns, and prognostic factors, in order to address potential unde...

Beyond Closed-Shell Photochemistry: Singlet Oxygen Generation Driven by 10H-Phenothiazine Radical Cation

Abstract Phenothiazines are widely studied as closed-shell photosensitizers; however, their open-shell oxidized forms remain largely unexplored in photochemical contexts. Here, we investigate the photophysics and reactivity of the radical cation of 10H-phenothiazine (PHT•+) using...

GENETIC AND PHARMACOLOGIC ACTIVATION OF BECLIN1 PREVENTSALDOSTERONE-INDUCED CARDIOVASCULAR DAMAGE

Aldosterone promotes endothelial dysfunction and cardiovascular injury through mineralocorticoid receptor (MR) activation. Autophagy is essential for endothelial homeostasis, yet its role in aldosterone-mediated vascular dysfunction remains unclear. We tested whether aldosterone...

Differences in corneal biomechanical parameters in normal tension glaucoma versus normotensive glaucoma suspect eyes

Abstract Multicenter retrospective study to evaluate differences in corneal biomechanical parameters provided by Corvis ST to segregate those with normal tension glaucoma (NTG) from glaucoma suspects. We included only newly diagnosed and treatment naïve glaucoma patients. Several...

A graph-based geospatial framework for delineating neighborhood planning units with barrier-aware isochrones

Graph-based GIS workflow is a relevant tool to urban planning and governance, yet most operational accessibility tools still rely on flat or Euclidean representations which can overestimate local dynamics in cities shaped by complex topography and fragmented urban forms. This lim...

Prevalence of Bartonella spp., Borrelia spp., and piroplasmid in HIV-infected symptomatic individuals in Brazil: a cross-sectional study

Abstract Background Bartonella spp., Borrelia spp., and piroplasmid are increasingly recognized as vector-borne pathogens worldwide, with documented circulation in arthropod vectors and animal reservoirs in Brazil. The purpose of this study was to assess whether Bartonella exposu...

Molecular characterization of a new emaravirus infecting Clerodendrum thomsoniae plants

Abstract High-throughput sequencing revealed a new emaravirus named clerodendrum yellow blotch virus (ClYBV), infecting Clerodendrum thomsoniae plants in São Paulo State, Brazil. Four genomic RNA segments (RNA1, RNA3, RNA4, and RNA5) were recovered, whereas RNA2 remained undetect...

Artificial intelligence for Amazonian health: validation is the price of entry

At the AI as Catalyst meeting in Manaus (July 28–29, 2026; https://ia-como-catalisadora-manaus.netlify.app), participants ran a simple exercise. Working in teams, they wrote about ten clinical cases and put each one to widely used general-purpose chatbots twice: first in standard...

Albumin-based cationic nanoemulsion for Protoporphyrin IX delivery in normoxic and hypoxic conditions

Glioblastoma is one of the deadliest cancers in humans, but its treatment is limited by the difficulty drugs have in crossing the blood-brain barrier. Albumin-based nanomaterials have emerged as promising drug delivery systems for neurooncology applications, particularly for the...

Neuroprotective effects of ketamine, lamotrigine, and ketoprofen combinations after pars plana vitrectomy and silicone oil injection

Abstract Purpose This experimental study aims to assess the protective impact of combined treatment with ketamine (KTM), lamotrigine (LMT), and ketoprofen (KTP), agents that have demonstrated neuroprotective properties in other experimental contexts, on rabbit retinas in an exper...

A mixed methods mapping of managerial competencies for hospital healthcare managers: implications for performance management and workforce development in a private Brazilian hospital

Abstract Background Managerial competencies shape how hospitals plan, execute and evaluate care processes, and in this study performance management is understood as the organizational cycle of planning, monitoring, evaluating and developing individual and team performance, wherea...

Efficacy evaluation of a fermented milk containing inactivated biomasses of Lacticaseibacillus rhamnosus and Saccharomyces cerevisiae to ameliorate the toxic effects of dietary aflatoxins and fumonisins in pigs: a pilot study

Abstract Inactivated microorganisms may reduce mycotoxins’ bioavailability, although in vivo evidence is limited especially in farm animals. This pilot study evaluated whether a fermented milk (FM) containing heat-inactivated biomasses of Lacticaseibacillus rhamnosus and Saccharo...

Evolutionary Dynamics-Aware De Novo Design of a Thermostable NS1-Derived Diagnostic Protein for Yellow Fever Virus

Abstract Serological diagnosis of neglected arboviruses remains hindered by extensive intra-genus cross-reactivity, compromising both assay specificity and epidemiological accuracy. In this study, we focused on yellow fever virus (YFV) as a model system to design and validate a g...

Antimicrobial coatings for bone regenerative scaffolds: Fabrication strategies and in vitro performance ─ A systematic review

Polymeric scaffolds coated with antimicrobials are promising for the treatment and prevention of osteomyelitis. The literature gap regarding the in vitro viability and applicability of these biomaterials throughout their development pipeline (manufacturing technique and coating m...

Barriers and drivers of industry 4.0 adoption: insights from a bibliometric analysis

Purpose This study aims to map the intellectual landscape of research on the barriers and drivers influencing Industry 4.0 (I4.0) adoption. By combining bibliometric and systematic review methods, it identifies the main contributors, research clusters and thematic trends shaping...

Strategic uses of the past and their liabilities: why government-pushed internationalization may fail

Abstract Governments push firms to internationalize not only through diplomacy and material incentives but also by shaping the environment in which investors, host governments, and local communities form judgments about cross-border opportunities. We conceptualize this process as...

Learning aligned EEG representations with subject-specific encoders

Cross-subject EEG decoding promises more training data, but it also exposes neural networks to strong inter-subject distribution shifts. We study whether task supervision and architecture alone can learn subject-aligned representations. We replace a shared EEG encoder with subjec...

J-PAS: Semisupervised Sim-to-Obs Transfer for Robust Star–Galaxy–Quasar Classification

Abstract Modern astrophysics and cosmology increasingly rely on simulations and cross-survey analyses, yet differences in instrumentation, calibration, and modeling introduce distribution mismatches between simulated and observed datasets (domain shift). This occurs when the join...

Ruminal Fermentation, Methanogenic Archaeal Diversity, and Metabolomic Responses to Urochloa brizantha Extracts in Sheep

Background: Phytogenic feed additives are being explored as alternatives to conventional rumen modulators, yet their effects on the ruminal ecosystem remain insufficiently characterized when assessed only through conventional fermentation parameters. This study evaluated the effe...