Tsinghua University

Discoveryof High-Affinity Peptide Ligands Targetingthe SPIN1 Tudor 3 Domain Via a Minimalist Pruning Strategy

Abstract Spindlin1 (SPIN1) is an epigenetic reader involved in oncology, whose third Tudor domain remains largely underexplored. Here, we applied a minimalist pruning strategy to the 26-mer peptide DOCpep3 to identify the core pharmacophore for SPIN1 Tudor 3 domain binding. This...

Randomized controlled trial of GenAI coach feedback efficacy, acceptability and mechanisms in anxiety worry logs

Abstract Anxiety disorders are prevalent worldwide, yet access to evidence-based interventions remains limited. Digital worry-log interventions are scalable, but unguided use may limit engagement and efficacy, while human-delivered feedback may improve outcomes, yet is labor-inte...

Remote Calibratinga National-Wide Dense Low-CostSensor Network for Hyperlocal Air Surveillance

Abstract Emerging low-cost sensor (LCS) technologies offer a unique opportunity to achieve equitable, high-granularity air surveillance. Yet without proper calibration, their raw observations are often considered invalid for rigorous research and regulatory purposes. Common calib...

Unraveling the Ionic Adsorption and Migration Mechanism of Inverse Opal Capacitive Deionization Electrode

ABSTRACT Developing advanced capacitive deionization electrodes for desalination requires the concurrent enhancement of thermodynamic and kinetic properties. Despite extensive research on improving thermodynamic features represented by adsorption capacity, the investigation on th...

Longitudinal association of dynamic changes in perceived family environment profiles and psychological problems among children: a latent transition analysis

Abstract This study aimed to identify distinct profiles of children’s perceived family environments and examine how these profiles and their transitions are associated with psychological symptoms. Data were drawn from 9,786 children (mean age = 9.92 years; 47.8% female; 55.7% Whi...

Electrical control of exchange bias in sub-10 nm regime enabled by single-nanotube patterning

Achieving stable magnetization in sub-10 nm ferromagnetic layers represents a fundamental bottleneck in spin-orbit torque magnetic random-access memory development. While exchange bias potentially offers stabilization at such scales through antiferromagnetic coupling, conventiona...

From Data to Decision:A Closed-Loop Framework forCo-Optimizing Energy Recovery and SO2 Control in SludgeGasification

Abstract The rapid expansion of urban wastewater treatment has rendered the sustainable management of sludge a global environmental challenge. Gasification technology is emerging as a promising treatment pathway due to its high conversion efficiency and resource recovery potentia...

Electron-DeficientSpecies-Driven Interphase Transformationfor Practical Lithium Batteries

Abstract Lithium metal batteries with Ni-rich layered cathodes are promising candidates due to their high energy density; however, the unstable interphase formed in traditional carbonates accelerates premature irreversible capacity loss. In this study, we exploit the electron-def...

Sample-efficient and generalizable velocity and pressure field reconstruction from three-dimensional two-phase flow interfaces

Abstract Accurate reconstruction of velocity and pressure fields from gas-liquid interfaces is essential for quantifying two-phase flow dynamics and enabling real-time flow visualization and diagnostics. This study presents a Transformer-based neural operator model pretrained on...

Influence of Operation Mode On The Performance and Component Matching and Multi-Objective Optimization of A Multi-Stream Adaptive Cycle Engine

Abstract The multi-stream adaptive cycle engine (ACE) represents a transformative propulsion concept for next-generation aircraft, offering the capability to dynamically balance thrust, efficiency, and thermal management across widely varying mission conditions. By incorporating...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

Public perceptions of positive and negative heritage values: a social media analysis of Shanghai’s old concessions

Abstract Value integrity is a critical dimension in heritage practice, yet the conflicting nature of values may result in the categorisation of positive and negative values, with the latter being neglected or even erased. Shanghai’s old concessions have carried complex and confli...

Impacts of Future Oil Palm Expansion on Carbon and Hydrological Fluxes Across the Tropics

Abstract Future oil palm expansion could substantially alter tropical carbon and water cycles, but its regional impacts remain unclear. Using CLM5‐palm, we simulate large‐scale oil palm expansion from 2023 to 2100 in Southeast Asia, Africa and the Amazon. Expansion increases tota...

The Carbon Trap: Fragmentation, Accounting Hegemony, and Justice in Global Carbon Governance

ABSTRACT Carbon accounting is increasingly treated as the technical foundation of global climate action, yet the rules through which emissions are measured, converted, attributed, and disclosed remain fragmented across national inventories, corporate reporting standards, supply‐c...

A family of ultrathin non-van der waals kamiokite-type oxides for two-dimensional electronics

Non-van der Waals (vdW) two-dimensional (2D) metal oxides provide an opportunity to enrich the current 2D material library and accelerate the adoption of 2D materials into future electronic devices. However, the exploration of 2D non-vdW oxides remains limited, constrained by syn...

Host Dearomatization for Prolonging Room‐Temperature Phosphorescence

ABSTRACT Host–guest doping has emerged as a powerful platform for constructing organic room‐temperature phosphorescence (RTP) materials, owing to its structural tunability and facile fabrication. However, molecular design has largely focused on guest molecules, while host screeni...

Mulberry Leaf Water Extract Ameliorates Impaired Glucose Tolerance via the Gut Microbiota/SCFAs/AMPKα1 Axis in Adipose Tissue

Background/Objectives: Impaired glucose tolerance (IGT) is a prediabetic condition affecting over 600 million adults worldwide. Mulberry leaf (Morus alba L.) has shown antidiabetic potential, but whether adipose AMPKα1 is required for its effects remains unclear. This study aimed...

Natural Sunlight IR‐Driven Highly Efficient Synthesis of Acetaldehyde From Bioethanol Over Cu/Fe 2 O 3

ABSTRACT Using renewable biomass to synthesize valuable chemicals can reduce fossil fuel dependence and achieve carbon neutrality. Here, for the first time an infrared light‐driven catalyst, Cu/Fe 2 O 3 , was designed to convert bioethanol to valuable acetaldehyde, accompanied by...

What is happening at the atomic level during the seed-mediated growth of copper on gold?

Bimetallic nanocrystals obtained via seed-mediated growth are typically analyzed using conventional electron microscopy and many interesting features at the atomic level are often missed. Here we report the seed-mediated growth of copper (Cu) on gold (Au) nanospheres for the synt...

A Hybrid Ridge Regression–Convolutional Bidirectional Long Short-Term Memory Framework with Dual-Level Transfer Learning for State-of-Health Estimation of Lithium-Ion Batteries Under High Temperatures

Accurate state-of-health estimation of lithium-ion batteries under high-temperature conditions (40–50 °C) remains challenging because of accelerated electrochemical degradation and strongly nonlinear aging patterns. This paper presents a hybrid Ridge regression–convolutional bidi...