Tsinghua University

Magneto-mechano-electrochemical fiber for deformation-resilient and smart electronic textiles

Electronic textiles represent a transformative platform for integrating technology into daily wear, yet their development has been undermined by a fundamental challenge: the conflicting requirements between mechanical deformation for functionality and structural stability for per...

Representative Bureaucracy in Private Philanthropy: Testing Discretion and Racial Representation in Community Foundation Grantmaking

As public service delivery increasingly involves non-governmental actors, public administration theory needs to examine how its core frameworks operate beyond traditional bureaucracies. This study extends representative bureaucracy theory to private philanthropy, an increasingly...

High‐Performance Liquid Crystal Elastomer Fibers via a Tandem Alignment Strategy

ABSTRACT Liquid crystal elastomer (LCE) fibers have shown great potential as shape‐memory soft materials due to their large and reversible deformation capacity. However, fabrication methods for LCE fibers with ultrafast thermal response and the exploration of the factors influenc...

Non‐metal Lewis Acid‐Catalyzed Reduction of Phosphine Oxides with Silanes: Mechanistic Study and Reaction Optimization

Non-metal Lewis acid (NM LA)-catalyzed silane-mediated reductions represent an important strategy for the conversion of phosphine oxides to phosphines. Although a variety of catalytic systems have been developed, their underlying reaction mechanisms remain insufficiently understo...

Multi-channel Non-radiative Dynamics to Reveal Δ E ST as the Key Efficiency Descriptor for Deep-Blue Pt(II) Phosphors

Abstract Tetradentate platinum(II) complexes are promising candidates for phosphorescent organic light-emitting diodes (OLEDs), combining deep-blue emission, high color purity, and potential for near-unity photoluminescence quantum yields (PLQYs). However, despite their rigid str...

Suppression of meiotic double-strand break formation in somatic cells by DREAM factors TCX5/6 maintains genome stability

Meiotic recombination in reproductive cells is initiated by DNA double-strand breaks (DSBs) and requires the expression of meiosis-specific genes, yet how the transcription of those genes is regulated in either meiotic or somatic cells remains unclear. Here, using a representativ...

Research Progress on Offline Defect-Detection Technologies for Selective Laser-Melting Parts

Selective laser melting (SLM) is recognized as one of the most promising metal additive manufacturing technologies for industrial deployment and has been applied to fabricate precision components for high-end equipment in sectors including aerospace and biomedicine. Nevertheless,...

Genome-Wide DNA methylation profiling of tissue-plasma pairs identifies Novel cfDNA biomarkers for the diagnosis of gastric cancer

Screening for gastric cancer (GC) is critical for improving patient survival, yet current clinical methods suffer from invasiveness and limited sensitivity. The aim of this study is to develop a machine learning model for the non-invasive diagnosis of GC using the whole-genome me...

A Standalone Flavoprotein Monooxygenase Directs Divergent Tropolone Skeletal Editing through Baeyer–Villiger-Triggered Rearrangement

Abstract Late-stage oxidative remodeling of tropolone cores underpins the remarkable scaffold diversity in fungal meroterpenoid biosynthesis. However, the mechanistic basis by which a single enzymatic catalyst diverts a common substrate toward carbon-excising ring contraction ver...

Modeling of vibrational non-equilibrium in detonation with global kinetics

One-, two-, and three-step global kinetic models that include thermal non-equilibrium were developed for detonation simulations using the open-source software Cantera and the Shock and Detonation Toolbox (SDToolbox). The rate coefficients and thermodynamic parameters of these mod...

Ca2+-Triggered Reinforcement of Polyacrylamide/Sodium Alginate Composite Nanogel Spheres for Regulating Multiphase Transport in Low-Permeability Heterogeneous Porous Media

Low-permeability heterogeneous porous media commonly exhibit preferential flow through high-permeability channels and persistent residual-oil trapping in small pores and dead-end regions, limiting effective multiphase transport and residual-oil mobilization. Herein, Ca2+-responsi...

Photocatalytic Three-Component Radical Addition of Aromatic Compounds

Abstract Substitution dominates benzene chemistry because σ-adducts formed during bond construction usually rearomatize. We report a photocatalytic three-component reaction that retains the σ-adduct as a 1,4-dioxygenated cyclohexadiene. A highly reactive carbonyloxy radical adds...

Cosmological Constraints from Full-scale Clustering and Galaxy–Galaxy Lensing with DESI DR1

Abstract We present constraints on cosmic structure growth from the analysis of galaxy clustering and galaxy–galaxy lensing with galaxies from the Dark Energy Spectroscopic Instrument (DESI) Data Release 1. Our analysis includes four samples drawn from the Bright Galaxy Survey (B...

Flexible PVDF-HFP Piezoelectric Nanofibers with In Situ rGO and BCZT for High-Sensitivity Tactile Sensing and Haptic-Visual Feedback

Abstract Flexible polymer-based piezoelectric sensors are promising for electronic skin and human–machine interfaces, but challenges remain in achieving efficient electromechanical conversion and sensitive low-pressure detection due to insufficient polarization and weak interfaci...

A Thermoelectric Hydrogel-Based Insole with Self-Decoupled Temperature and Pressure Sensing for Diabetic Plantar Monitoring

Abstract Plantar temperature and pressure reflect the plantar health status of diabetic patients and serve as critical indicators for evaluating disease progression. However, existing plantar monitoring devices are still limited by single-modal signal acquisition, bulky device co...

Osteoporosis treatment via programmed delivery of IRF5 siRNA to macrophages in bone tissue combined with ROS scavenging

Postmenopausal osteoporosis (PO) is not merely a consequence of increased osteoclast activity. Estrogen deficiency induces oxidative stress and pro-inflammatory M1 macrophage polarization in bone tissue, thereby sustaining osteoclastogenic stimuli and pathological bone resorption...

Developing optimal operating rules for a multi-reservoir system with multi-objective water utilization and multi-year carryover storage: A case study of the Upper Yellow River

Study region The multi-reservoir system on the Upper Yellow River, China, comprising Longyangxia, Laxiwa, Lijiaxia, Gongboxia, Jishixia, and Liujiaxia. Study focus To address the difficulty of directly translating optimal operation results under multi-reservoir, multi-objective,...

Regulation of target gene expression by chromatin-associated protein-coding transcripts in plants

Protein-coding transcripts are regarded as intermediates that mediate DNA-to-protein information flow, leaving their noncoding regulatory potential largely underappreciated. Genome-wide profiling of RNA–chromatin interactions in Arabidopsis has uncovered widespread associations b...

Molecular-scale origins of shear-thinning in SiO₂-Al₂O₃-CaONa₂O slag: High-temperature rheology and non-equilibrium molecular dynamics

SiO₂-Al₂O₃-CaO Na₂O slag represent the basic constituents of high-alkali coal ash, and its non‑Newtonian rheology critically affects ash deposition and transport. In this study, their shear‑thinning behavior was investigated by combining high‑temperature rheometry (0–500 s⁻¹) wit...

Orthogonal Fc engineering enables multiplexed delivery of mRNA-encoded bispecific antibodies that constrain viral escape

The continuous antigenic evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has repeatedly undermined the effectiveness of monoclonal antibody (mAb) therapies, underscoring the need for innovative approaches that improve therapeutic mAb breadth and durabili...