The University of Tokyo

Enhancing Current-Source Imaging in Magnetocardiography: The Impact of Sensor Array Configuration

Abstract While magnetocardiography (MCG) is a non-invasive tool for assessing cardiac electrophysiology, its conventional planar sensor array often struggles to accurately estimate sources distant from the sensor. This limitation hinders the precise localization of deep cardiac a...

Branching Laws for Stein’s Complementary Series and Speh Representations of $$\textrm{GL}(2n,\mathbb {R})$$

Abstract We obtain the explicit direct integral decomposition of Stein’s complementary series representations and Speh representations of $${{\,\textrm{GL}\,}}(2n,\mathbb {R})$$ GL ( 2 n , R ) when restricted to the subgroup $${{\,\textrm{GL}\,}}(2n-1,\mathbb {R})$$ GL ( 2 n - 1...

Lysophosphatidic acid promotes cutaneous wound healing through vascular maturation and fibroblast activation in a murine model

BACKGROUND: Impaired cutaneous wound healing is a major clinical burden, particularly among older individuals and patients with diabetes. Lysophosphatidic acid (LPA) is a bioactive phospholipid with known roles in cell proliferation, migration, and vascular formation; however, it...

Optimizing entanglement manipulation via algebraic–geometric decompositions and semi-definite programming hierarchies

In the study of distributed quantum information processing, it is a fundamental problem to optimize local operations in the implementation of non-local quantum operations assisted by limited entanglement. We develop an algebraic–geometric framework that systematically simplifies...

Understanding the Research Needs and Educational Methods of Surgeons to Help Guide Future Spine Deformity Research: A Survey of AO Spine Members

Study Design Cross-sectional survey. Objective Outcomes research has significantly shaped patient management in spine deformity care, while the dissemination of research remains a challenge. To guide future research directions, this study surveyed AO Spine members to identify the...

“Smelltronics”—From Gas to Smell Sensing

This review discusses recent trends in smell and odor-sensing studies, including materials, devices, and interfaces. Since the invention of chemical sensors, particularly over the past few decades, gas sensor materials and devices for small molecules have been extensively investi...

Impact of prostaglandin-related antiglaucoma medication use on levator aponeurosis advancement outcomes

To evaluate postoperative eyelid height at 3 months after levator aponeurosis advancement with or without concomitant skin excision in eyes with and without prostaglandin-related antiglaucoma medication use. This retrospective single-center study included patients who underwent l...

Sensory nerves regulate bone homeostasis in response to mechanical unloading or reloading: evidence from a spaceflight experiment and ground-based mechanical unloading models

Mechanical loading is crucial for maintaining bone mass, and understanding how bone remodels in response to mechanical loading is essential for treating musculoskeletal disorders. Recently, sensory nerves inside bone were identified as mechanical regulators of bone homeostasis. H...

Long-Term Survival Outcomes of Modified-FOLFOXIRI Plus Cetuximab Versus Bevacizumab in RAS / BRAF Wild-Type Metastatic Colorectal Cancer: Final Analysis of the DEEPER Trial

The randomized phase II DEEPER trial (jRCTs061180022) previously reported superior depth of response with modified 5-fluorouracil, leucovorin, oxaliplatin and irinotecan (m-FOLFOXIRI) plus cetuximab versus bevacizumab in patients with RAS wild-type metastatic colorectal cancer (m...

Towards A Universal Analytical Model of Population III Star Formation: A Bridge Between Cosmological Scales and Protostars

Abstract We construct an analytical model of Population III star formation that connects the cosmological radiation background to sub-AU protostellar disk fragmentation, a dynamic range inaccessible to any single simulation. Our approach is based on combining separate models of t...

Histological Determinants of Atrial Dysfunction in Patients With Atrial Fibrillation

Background Atrial fibrillation (AF) is associated with diverse histological abnormalities, but their contributions to atrial dysfunction and functional recovery remain unclear. Methods In a discovery cohort of 375 patients with nonvalvular AF undergoing catheter ablation, atrial...

Photocatalytic proximity labeling for the identification of G-quadruplex DNA-interacting proteins

Abstract DNA–protein interactions play an essential role in fundamental cellular biological processes. Herein, we report a photocatalytic proximity labeling approach for the broad screening of G-quadruplex (G4)-interacting proteins (G4IPs) using human telomere G4 DNA modified wit...

Direct speciation of ultra-trace platinum in marine ferromanganese oxides by wavelength-dispersive XAFS

Abstract Ultra-trace platinum (Pt) in marine ferromanganese oxides (FMOs) has remained inaccessible to direct XAFS analysis because of its extremely low abundance and severe interferences from co-existing elements. We achieved the first direct speciation of Pt at the 1 μg g−1 lev...

Winter sediment resuspension in a submarine canyon drives the offshore export of toxigenic Alexandrium catenella cysts

Abstract Harmful algal blooms (HABs) caused by the toxigenic dinoflagellate Alexandrium catenella recur regularly in the Lower St. Lawrence Estuary (LSLE, eastern Canada). Using quantitative polymerase chain reaction (qPCR) to detect A. catenella DNA as a proxy for cyst abundance...

Development of a Photostable pH Biosensor Based on mStayGold

Fluorescent proteins (FPs) that are pH-sensitive play a crucial role in investigating pH-related cellular processes, such as endocytosis and exocytosis. Existing pH-sensitive FPs generated from Aequorea victoria green fluorescent protein (GFP), such as superecliptic pHluorin (SEP...

Cohesin acts as a transcriptional gatekeeper by restraining pause–release to promote processive elongation

Abstract Cohesin organizes 3D chromatin architecture, including promoter–enhancer loops, yet its loss has surprisingly modest effects on steady-state gene expression. We address this paradox by demonstrating that cohesin acts at different stages of transcription. First, it promot...

SYK inhibitor fostamatinib promotes mitochondrial respiratory chain supercomplex formation and improves skeletal muscle function in aged mice

Mitochondria are major organelles involved in energy metabolism and play a crucial role in the function of muscular tissues. Mitochondrial respiratory chain (MRC) complexes are assembled to higher-order “MRC supercomplex (SC)” structures, which has been suggested to promote energ...

Protocol of the STRIDE-X study: a multicenter, single-arm trial of single tremelimumab regular interval durvalumab followed by hepatectomy for initially unresectable hepatocellular carcinoma

Abstract Background Hepatocellular carcinoma (HCC) ranks as the fifth most common cancer globally and the third leading cause of cancer-related death. Systemic therapies such as lenvatinib or the combination of atezolizumab and bevacizumab has recently emerged as a first-line the...

Wasserstein projection estimators for circular distributions

For statistical models on circles, we investigate performance of estimators defined as the projections of the empirical distribution with respect to the Wasserstein distance. We develop algorithms for computing the Wasserstein projection estimators based on a formula of the Wasse...

From Swarm to Individual: Emergent Individuality in Light‐Mediated Robot Collectives

Collective behavior is often modeled as the outcome of interactions among similar agents, while variation among individuals is commonly treated as a property that agents bring into the group. Here, we take a complementary view: Individual differences can also be produced, amplifi...