The University of Texas Southwestern Medical Center

Fatigue-induced decline and recovery of maximal motor unit firing rates did not differ between males and females in two muscles of the quadriceps femoris

Studies on sex-related differences in motor unit (MU) behaviour with muscle fatiguing tasks are limited, particularly during contractions of maximal intensity and usually to one muscle within a synergistic group. Therefore, the purpose was to investigate the influence of sex and...

Racial and Ethnic Differences in Classic and 11-Oxygenated Androgens in Men

BACKGROUND: Androgen-dependent prostate pathology, including prostate cancer and benign prostatic hyperplasia, differs in prevalence and phenotype across races/ethnicities. Adrenal-derived 11-oxygenated C19 steroids (11-oxyandrogens) are relevant to several androgen-dependent pat...

Effects of Dapagliflozin on the Bone of Patients with CKD on Dialysis

The effects of gliflozins on bones of CKD patients on dialysis are unknown. Recently, SGLT2 expression in bone tissue of patients with CKD has been reported. We hypothesized that dapagliflozin may act in bone cells and modulate the Klotho-FGF23 axis. This study analyzed the effec...

A generalized supervised contrastive learning framework for integrative multi-omics prediction models

Abstract Recent technological advances have highlighted the significant impact of the human microbiome and metabolites on physiological conditions. Integrating microbiome and metabolite data has shown promise in predictive capabilities. We developed a new supervised contrastive l...

Urinary Biomarkers for the Risk Assessment and Management of Heart Failure: Pearls and Pitfalls

PURPOSE OF REVIEW: We review potential applications and pitfalls of urinary biomarkers in people with heart failure (HF). RECENT FINDINGS: Albuminuria may indicate kidney damage and guide prioritization of medications in HF. Urine sodium is useful in guiding diuretic management....

“Molecular divergence shapes lung- and liver-preferential metastasis in HER2-positive breast cancer”

Abstract Metastatic colonization of distant organs remains the primary cause of breast-cancer-specific mortality, yet the underlying mechanisms governing organ-preferential colonization remain poorly understood. To better delineate the underlying mechanisms to establish successfu...

Management of Infantile Epileptic Spasms Syndrome: A survey of US pediatric hospitals

Abstract Objective To evaluate the management practices of Infantile Epileptic Spasms Syndrome (IESS) across tertiary pediatric hospitals in the United States using a survey‐based approach. Methods A 21‐question survey focused on management setting, work‐up, follow‐up and treatme...

Transcriptomic insights into age-associated extracellular matrix promotion of breast cancer

Aging is a key risk factor for breast cancer; however, the independent effects of the aged extracellular matrix (ECM) remain understudied. To address this, we developed a novel hybrid in vivo model that enables the independent investigation of age-related ECM influences on breast...

Region-Specific Brain Imaging Correlates of Repetitive Head Impact Exposure in Nonconcussed High School Football Players

Repetitive, nonconcussive head impacts in collision sports are associated with lasting neurophysiological effects. This study investigates region-specific changes in neocortical mean diffusivity (MD) and resting-state functional magnetic resonance imaging (fMRI) power spectral de...

Multimodal AI for automated assessment of surgical performance

Accurate and objective assessment of surgical skill is crucial for improving training outcomes, ensuring patient safety, and enabling scalable evaluation across clinical and simulation contexts. Current approaches often depend on subjective human ratings or unimodal analysis, lim...

Postoperative Complications Following Total Knee Arthroplasty in Patients with Chronic Lymphocytic Leukemia

Background/Objectives: Chronic lymphocytic leukemia (CLL), the most common leukemia in adults, predominantly affects the aging population. With improved survival from modern targeted therapies, a growing number of CLL patients are living long enough to become candidates for quali...

Is Proton Therapy Superior to Gamma Knife Radiosurgery for Sporadic Vestibular Schwannoma?

With changing practice patterns, radiation therapy for vestibular schwannomas has become an increasingly utilized treatment modality with high tumor control rates. Gamma-Knife radiosurgery remains a well-established and readily accessible option with good rates for tumor control,...

Disparities in Hospital Length of Stay and Morbidity in Acute Care Pediatric Cardiology Patients

BACKGROUND Multicenter collaborative studies examining disparities in in-hospital outcomes are lacking in pediatric cardiology. We hypothesized that Black and Hispanic patients in pediatric acute care cardiology units (ACCUs) have increased length of stay (LOS) and complications...

High-Throughput Proteomicand Glycoproteomic Analysesin Benign Prostatic Hyperplasia

Abstract Benign prostatic hyperplasia (BPH) is a disease affecting the majority of aging men; 90% of men develop histological BPH by the time they reach their eighties. BPH can lead to bothersome lower urinary tract symptoms (LUTS), which may reduce quality of life. Many patients...

Safety and Efficacy of Colchicine for the Treatment of Pericarditis in Patients with Chronic Kidney Disease

This retrospective multicenter cohort study compared the safety and efficacy of low- versus high-dose colchicine in adult patients with chronic kidney disease (CKD) treated for pericarditis between August 2015 and August 2024. CKD was identified using ICD codes and confirmed by a...

Non-enzymatic hepatic ABHD6 interacts with Akt-FoxO1 axis to regulate metabolic health

The enzymatic role of ABHD6 in insulin secretion and resistance is well documented. However, its non-enzymatic function, especially its effects on metabolic health, including selective hepatic insulin resistance and metabolic dysfunction-associated steatotic liver disease (MASLD)...

Plain language summary of how acoramidis affects the total number of heart problems over time in people with ATTR-CM: findings from the ATTRibute-CM study

Plain Language SummaryWhat is this summary about?Transthyretin amyloid cardiomyopathy (ATTR-CM) happens when transthyretin (TTR) protein breaks apart, forming clumps that build up in the heart, making it harder to pump blood.People with ATTR-CM often go to the hospital multiple t...

Effect of time to palliative epilepsy surgery on outcomes

Abstract Objective Epilepsy duration is a modifiable risk factor in the outcome of definitive epilepsy surgery; however, an analogous effect in palliative procedures has not been shown. We reviewed the Pediatric Epilepsy Surgery Database data for an association between epilepsy d...

Comparisons of Novel Risk Stratification Models to the Current cT1a/b Staging in Incidental Prostate Cancer

OBJECTIVE: Incidental prostate cancer (PCa) patients are currently stratified to either cT1a vs. cT1b stage, depending on tumor volume (< 5% vs. > 5%) in the resected tissue. We tested for other models that could improve cancer-specific survival (CSS) predictions. METHODS: Incide...

Spontaneous lung cancer metastasis models as a novel platform for lung cancer translational research

Lung cancer is the leading cause of cancer mortality in the U.S., most of which is due to metastatic disease. Although the addition of immune checkpoint inhibitors (ICI) has transformed therapy for metastatic lung cancer, the vast majority of patients experience disease resistanc...