The University of Texas Southwestern Medical Center

Exploratory integrative analysis of infant gut microbiome and metabolome suggests diet- and microbiome-derived metabolites associated with childhood asthma

Abstract Background Early-life gut microbiome composition has been linked to childhood asthma risk, but the metabolic pathways underlying this association remain unclear. Objective To integrate infant gut microbiome and metabolome data to identify pathways associated with asthma...

Standards for practical management of drug hypersensitivity reactions to intravenous drugs and proactive early allergy involvement before referral: A WAO Statement

Hypersensitivity reactions to intravenous therapies—including antibiotics, chemotherapeutics, biologics, anesthesia agents, and contrast media—pose significant challenges in acute care settings. These reactions often occur outside the purview of allergy specialists, leading to de...

Autonomic-Immune Crosstalk in Lupus: Impaired Cholinergic Signaling and Consequences for Cardiovascular-Renal Physiology

Over the years, our group has used complementary approaches to examine how autonomic-immune crosstalk influences the pathogenesis of systemic lupus erythematosus (SLE). We found that pharmacological enhancement of vagal activity and engagement of the parasympathetically-mediated...

Adapting an EHR-Based Intervention to Reduce Preprocedural Fasting in Hospitalized Children

INTRODUCTION: Prolonged preprocedural fasting in hospitalized children persists despite American Society of Anesthesiologists (ASA) guidelines permitting clear liquids up to 2 hours before anesthesia. Prior work demonstrated that an electronic health record (EHR) order with ASA-a...

Long‐Term Follow‐Up of Dysphagia After Type I Laryngeal Cleft Repair

ABSTRACT Objective To evaluate the long‐term course of dysphagia after surgical treatment of Type I laryngeal cleft (LC‐1). Methods A retrospective review was conducted on consecutive children with persistent swallowing dysfunction after surgical treatment of LC‐1. Swallowing fun...

Retinal optical coherence tomography angiography as a bedside guide for perioperative resuscitation

We explored the feasibility of utilizing optical coherence tomography angiography (OCTA) device in a peri-operative setting to assess the perfusion status of the retinal microcirculation by perturbating a quantitative macrocirculatory target - mean arterial pressure (MAP), and by...

Association of Habenula Activity and Volume with Pediatric Irritability: Investigation of Inconsistent Parenting as a Moderator

OBJECTIVE: Irritability significantly impacts the mental health and well-being of youth and their families and is associated with adverse concurrent and future outcomes. Brain abnormalities in the reward system are a potential mechanism underlying irritability. However, the haben...

Mechanics of electroadhesion by polycation interfacial bridging: sticky electrophoresis, ionic complexation and chain entanglement

Abstract An e-GLUE is a polymer network containing interpenetrating polycations, which can bond the anionic network of mucosa by polycation interfacial bridging under an electric field. This paper formulates a theoretical model to study such electroadhesion by electrophoresis of...

The PancreaSure Multianalyte Blood Test Performs Well at Distinguishing Early-Stage Pancreatic Ductal Adenocarcinoma from High-Risk Controls: A Retrospective Secondary Analysis

Background/Objectives: Biomarkers that can facilitate early detection of pancreatic cancer and extend patient survival are a significant unmet need. PancreaSure is a serum biomarker signature that performed well at distinguishing Stage I and II pancreatic ductal adenocarcinoma (P...

Conserved C-terminal residues adjacent to the canonical PDX1 homeodomain are required for chromatin occupancy and pancreas development

Essential roles for the PDX1 transcription factor in pancreatic development and β-cell function are well-known, yet the structure-function relationships of domains within its C-terminus remain incompletely defined. We identified a focal intrinsically disordered region (IDR) spann...

Olfactomedin 4 marks progenitor cells that give rise to the secretory cell lineage in the mouse cervix

Goblet cells, a specialized secretory cell type of mucosal epithelia, provide barrier function to the female lower reproductive tract. Current understanding proposes that squamous and secretory cells of the mouse cervicovaginal epithelium arise from a common Trp63+ progenitor. By...

The liver niche accelerates, while the lung niche restrains secondary spread of breast cancer

Breast cancer progression to visceral organs such as the lung and liver is associated with poor prognosis. Yet, these organs have diverse cellular microenvironments that may differentially influence cancer cell behavior. Here, we show that breast cancer metastases differ in their...

Global Paid and Unpaid Productivity Losses Due to Gastrointestinal Cancer Mortality

OBJECTIVES: Gastrointestinal (GI) cancers contribute substantially to premature mortality, yet their full economic burden, including unpaid work, remains underquantified. We aimed to estimate global productivity losses attributable to GI cancer mortality, considering paid and unp...

Care of the Infant With Congenital Cytomegalovirus Infection: Clinical Report

This clinical report addresses recognized knowledge gaps regarding congenital CMV infection (cCMV) in infants and expands on information present in the 2024-2027 Red Book. The clinical report reviews the epidemiology of cCMV, clinical manifestations of cCMV disease and cCMV with...

Utility and best practices for clinical diagnostic testing of the autonomic nervous system: A Consensus Statement Endorsed by the American Autonomic Society and the American Association of Neuromuscular & Electrodiagnostic Medicine

Abstract Purpose Disorders of the autonomic nervous system are prevalent and associated with substantial morbidity, mortality and diagnostic delay. Standardized, laboratory-based autonomic function testing provides objective physiological data essential for diagnosing, staging, a...

Clonal Hematopoiesis of Indeterminate Potential Proteomic Risk Score for Predicting Clinical Outcome in Patients With Heart Failure With Preserved Ejection Fraction

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) is common in heart failure with preserved ejection fraction (HFpEF). However, the proteomic signatures linked to CHIP driver mutations and their prognostic implications in HFpEF remain poorly defined. We aimed to...

Effect of Semaglutide on Thigh Skeletal Muscle Volume, Fat Infiltration and Physical Function in People With Obesity: Secondary Analysis of STEP UP

ABSTRACT Aims To assess the effect of semaglutide on body composition and physical function. Materials and Methods The phase 3b STEP UP trial randomised adults with body mass index ≥ 30 kg/m 2 to once‐weekly subcutaneous semaglutide 7.2 mg, semaglutide 2.4 mg or placebo for 72 we...

Molecular based diagnostic testing for urinary tract infections: the results remain unclear

INTRODUCTION: Recent advances have led to a rise in metagenomic and molecular-based testing for more rapid diagnosis of urinary tract infections (UTI). We conducted a contemporary systematic review to understand how these molecular tests affect clinical outcomes. METHODS: A syste...

Outcome-grounded effect of clinically stigmatizing information on large language model emergency triage prioritization

Whether stigmatizing input language biases large language model (LLM) triage prioritization against acutely ill patients is unknown. In a controlled, outcome-grounded experiment at two academic emergency departments, Emergency Severity Index-matched pairs (one deteriorating withi...

Hyperoxia and neurologic complications in pediatric veno-arterial extracorporeal membrane oxygenation: a retrospective ELSO registry study

Hyperoxia can contribute to neurologic injury through oxidative injury and platelet activation leading to microvascular thrombosis in critical illness. We aimed to determine if hyperoxia exposure during ECMO is associated with increased neurologic complications. Secondarily, we a...