Care of the Infant With Congenital Cytomegalovirus Infection: Clinical Report
Abstract
This clinical report addresses recognized knowledge gaps regarding congenital CMV infection (cCMV) in infants and expands on information present in the 2024-2027 Red Book. The clinical report reviews the epidemiology of cCMV, clinical manifestations of cCMV disease and cCMV with isolated sensorineural hearing loss (SNHL), diagnosis of cCMV, and treatment of cCMV disease and cCMV with isolated SNHL. The current advantages and disadvantages of different approaches to screening for cCMV infection are reviewed with a recommendation for hearing-targeted (HT) plus expanded testing. Additionally, the initial evaluation for an infant with cCMV and current knowledge of prevention efforts are discussed. Key action statements are provided.
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Authors: Brenda L. Tesini, Mary T. Caserta, Albert H. Park, Karen M. Puopolo, Brian K. Reilly, Dennis Z. Kuo, Christoph U. Lehmann, Sean T. O’Leary, James D. Campbell, Monica I. Ardura, Kristina A. Bryant, Roberta L. DeBiasi, Claudia Espinosa, Robert W. Frenck, C. Mary Healy, Betsy C. Herold, Chandy C. John, Aaron M. Milstone, Angela L. Myers, Pia S. Pannaraj, Adam J. Ratner, José R. Romero, Matthew Zahn, Section on Otolaryngology–Head and Neck Surgery, Jeffrey Philip Simons, Steven E. Sobol, Kavita Dedhia, Thomas Gallagher, Peggy Elaine Kelley, Pamela Anne Mudd, Samuel Ostrower, Eileen Margolies Raynor, Alanna Windsor, Karen Puopolo, Namasivayam Ambalavanan, Mandy Brown Belfort, Charleta Guillory, Margaret Parker, Arun Pramanik, Jonathan Slaughter, Kelly Wade, Rishi Agrawal, Deanna S. Bell, Robin Blitz, Ellen Fremion, Sheryl Frierson, Ruchi Kaushik, Michelle Melicosta, Kristin Sohl, Siddharth Srivastava, Jilda Vargus-Adams, Katharine E. Zuckerman
Institutions: Children's Hospital of Philadelphia, University of Utah, University of Rochester Medicine, The University of Texas Southwestern Medical Center, Children's National, University of Utah Hospital