The University of Texas Southwestern Medical Center

The Parkinsonian Motor Spectrum in Nonagenarians: A Population‐Based Study

BACKGROUND: Population-based data on mild parkinsonian signs (MPS) and parkinsonism in nonagenarians are scarce. OBJECTIVES: To estimate the prevalence of MPS, definite parkinsonism, and broader parkinsonian motor phenotypes; assess MPS after excluding idiopathic Parkinson diseas...

Large Calyceal Diverticulum Mimicking a Solid Renal Mass in a Patient Undergoing 68Ga-DOTATATE PET/CT

A 41-year-old man with grade 1, well-differentiated neuroendocrine tumor (NET) of the terminal ileum underwent initial staging with 68Ga-DOTATATE PET/CT. PET/CT images demonstrated focal uptake at the terminal ileum corresponding to the patient's known NET. In addition, a large,...

The Modern Urology Pipeline: Career Trajectories of Recent Residency Graduates

INTRODUCTION: Urology residency graduates face a pivotal transition when deciding on fellowship training and eventual practice setting. While traditionally a fellowship was a gateway to academia, recent trends reveal increasing pursuit due to job market concerns and perceived gap...

Radiology considerations for the PREMIUM study: a multicenter randomized controlled trial of abbreviated MRI versus ultrasound for liver cancer screening in cirrhosis

Abstract This paper describes the rationale and radiology considerations in the implementation of the Preventing Liver Cancer Mortality through Imaging with Ultrasound versus MRI (PREMIUM) study. PREMIUM is a multicenter, randomized controlled trial sponsored by the Department of...

Electroclinical classification of idiopathic generalized epilepsy syndromes at initial evaluation: A prospective multicenter study

Abstract Objective To determine the extent to which electroclinical information available at initial evaluation allows classification of idiopathic generalized epilepsy (IGE) syndromes, and to assess the contributions of seizure semiology and age at seizure onset to early syndrom...

Engineering microRNAs as multimodal cancer therapeutics

Resistance to systemic therapy remains a major challenge in non-small cell lung cancer (NSCLC). Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have improved outcomes for patients with EGFR-mutant tumors, but acquired resistance is common and can arise t...

Circulating Biomarkers in Cardio-Oncology: Prediction and Prognostication

Circulating biomarkers are increasingly utilized in cardio-oncology for risk stratification, early detection, and prognostication of cancer therapy-related cardiovascular toxicity. This review summarizes the current evidence supporting established and emerging biomarkers, with a...

A biochemical mechanism for Stu2/XMAP215-family microtubule polymerases

Abstract Defining quantitative biochemical mechanisms of microtubule dynamics and regulation is a current challenge. Stu2/XMAP215-family polymerases use tubulin-binding TOG domains to catalyze microtubule growth, but how polymerase activity results from the number and tubulinbind...

Global variability in cardiovascular care of pediatric cancer patients and survivors: survey results from the International Cardio Oncology Society (ICOS)

Childhood cancer survivors (CCS) are at elevated risk for cardiovascular disease due to cardiotoxic cancer therapies. Different international guidelines and recommendations for follow-up were published. However, global practices surrounding cardiovascular risk assessment, screeni...

Pseudomonas aeruginosa Impairs Mitochondrial Function During Infection of Corneal Epithelial Cells

Purpose: Pseudomonas aeruginosa (PA) is a Gram-negative opportunistic bacterial pathogen that can infect the cornea as a result of trauma or contact lens wear. Mitochondria, originally derived from bacteria, play important roles in host defense. This study investigated the effect...

Self-organization of vascularized muscle from bovine embryonic stem cells

Abstract Cultured beef offers a promising alternative to traditional meat. While adult stem cells are commonly used as the cell source for cultured beef, their proliferation and differentiation capacities are limited. Current manufacturing processes for cultured beef steaks often...

Care Models for the Genetic Evaluation of Dilated Cardiomyopathy at Sites of the DCM Consortium

Abstract Background Clinical genetic evaluation for patients with dilated cardiomyopathy (DCM) is minimally implemented and models of care are not defined. To understand current genetics care for DCM, a systematic needs assessment was conducted. Methods Principal Investigators (P...

Bronchoscopic Ablation and Intratumoral Therapies for Lung Cancer: Expanding Local Treatment Beyond Surgical Resection

Advances in navigational bronchoscopy, robotic platforms, and intraprocedural imaging have transformed bronchoscopy from a diagnostic modality into a potential therapeutic platform for localized treatment of lung cancer. These developments are particularly relevant for patients w...

Statins Use in Veterans With Peripheral Artery Disease: Insights From the PEARLS Study

BACKGROUND: Guidelines recommend high-intensity statins in patients with peripheral artery disease (PAD). We examined contemporary use of statins among real-world patients with a new diagnosis of PAD. METHODS: Within a national registry of Veterans with incident PAD, we used phar...

Sleep disturbances in children with cystic fibrosis on highly effective modulator therapy referred for polysomnography

Sleep disturbances are increasingly recognized in children with cystic fibrosis (CF), including those on highly effective modulator therapy (HEMT), but polysomnographic data remain limited and the factors associated with these disturbances are poorly understood. Single-center ret...

Alcohol Use Severity Among Hispanic Emerging Adult College Students: Examining Acculturation Stress, Self-Esteem, and Resilience in a Stress and Coping Framework

Research on acculturation stress and its effects on alcohol-related outcomes among Hispanics has been the subject of many studies. However, these studies are limited because they generally use a single measure of acculturation stress to account for this complex construct, and mos...

International Society of Urological Pathology Multidisciplinary Expert Consultation Conference on Evaluation of Treatment Effects in Prostate and Bladder Cancer

Treatment effects in the urinary bladder are variable and range from localized post-transurethral resection changes to widespread systemic therapy effects. The International Society of Urological Pathology (ISUP) organized a consensus meeting in Vienna, Austria, in September 2025...

Shoulder Internal and External Rotator Strength Reliability and Validity in Healthy Adolescent Athletes

Background Handheld dynamometry (HHD) has been recommended in return-to-play (RTP) assessments following shoulder injuries; however, variations in testing methods limits interpretation of results. In contrast, isokinetic dynamometry is considered gold-standard for assessment of s...

Standard Versus Arm-Length-Normalized Conditions for Assessment of the Closed Kinetic Chain Upper Extremity Stability Test in Healthy Youth Athletes

Background Criterion-based assessment of shoulder function includes screenings, such as the Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST), to help identify deficits in stability, neuromuscular control, and proprioception. However, normative performance for the CKC...

Lipoprotein (a) Testing and Changes in Lipid-Lowering Therapy in Patients With ASCVD: Findings From the cvMOBIUS-2 Registry

BACKGROUND: Although the effectiveness of Lp(a) (lipoprotein[a])–lowering therapies remains under study, lipid guidelines now recommend Lp(a) testing in all adults to identify individuals who need more aggressive risk factor modification. Therefore, we evaluate contemporary patte...