Sun Yat-sen University

2D Covalent Organic Frameworks as Robust n‐Type Organic Mixed Ionic‐Electronic Conductors for Electrochemical Transistors

ABSTRACT Organic mixed ionic‐electronic conductors (OMIECs) with exclusive electrochemical modulation and coupling between ions and electrons have exhibited intriguing efficiencies in bioelectronics, logic circuits, and wearable devices. However, OMIECs are typically linear polym...

Revisiting HAIC and systemic treatment for initially diagnosed HCC with major portal vein (Vp3/4) tumor thrombosis

Hepatocellular carcinoma (HCC) with major portal vein tumor thrombosis (PVTT) has a dismal survival expectancy. The treatment for HCC with major PVTT remains challenging. The aim of the study was to revisit the survival outcomes and safety of locoregional hepatic arterial infusio...

52‐week ivarmacitinib in moderate‐to‐severe atopic dermatitis: A phase 3 trial

BACKGROUND: Ivarmacitinib, an oral JAK1 inhibitor, improved efficacy outcomes versus placebo at Week 16 in a phase 3 trial in patients with moderate-to-severe atopic dermatitis (AD). OBJECTIVES: To describe efficacy and safety outcomes through Week 52. METHODS: In this multicentr...

Trace Al/Rb regulation stabilizes Cu-Fe5C2 active sites for ambient-pressure photothermal CO2 hydrogenation to C2-C4 olefin

Photothermal hydrogenation of CO2 offers a solar-driven route to multicarbon hydrocarbons, but controlling carbide formation and maintaining reconstructed active sites remain challenging for iron-based catalysts. Here, we develop a trace Al/Rb co-promoted CuFe2O4 catalyst that en...

Low-Complexity Three-Layer GII Encoders Based on a Grouping Strategy

Generalized integrated interleaved (GII) codes have emerged as a compelling coding solution for distributed storage systems, as they achieve a favorable tradeoff between error-correcting capability and repair locality. Compared with conventional two-layer GII codes, three-layer G...

Resource Competition Between Melon Fly, Zeugodacus cucurbitae and Oriental Fruit Fly, Bactrocera dorsalis

The melon fly, Zeugodacus cucurbitae, and the oriental fruit fly, Bactrocera dorsalis, are economically important tephritid pests whose sympatric distribution and overlapping host ranges precipitate intense interspecific competitive interactions. To explore the interspecific comp...

Baseline airway dysfunction and small-airway abnormality burden are longitudinally associated with adverse ultradistal radial bone density outcomes in a 5-year cohort

Impaired pulmonary function has been linked to lower bone mineral density and higher fracture risk, but longitudinal evidence on airway dysfunction and subsequent peripheral bone-density outcomes remains limited. We investigated whether baseline airway dysfunction, FEV1/FVC, and...

Efficacy and safety of upadacitinib for Crohn’s disease in patients in East Asia: a post hoc analysis of randomized phase 3 studies

Abstract Background Upadacitinib is an oral Janus kinase inhibitor approved for the treatment of moderate-to-severe Crohn’s disease (CD). This post hoc analysis reports the efficacy and safety of upadacitinib for CD in patients in East Asia enrolled in the phase 3 clinical trials...

In Vitro Litholytic Effects of Three Chinese Herbal Extracts on Mixed-Type Urinary Calculi.

litholytic effects on this mixed-type calculus subtype，suggesting their potential as therapeutic agents for clinical management of urolithiasis.

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

ABSTRACT Developing effective therapies for triple‐negative breast cancer (TNBC) requires the identification of key molecular regulators. Here, among the major m6A modulators, we find that only the reader YTHDC1 is specifically overexpressed in TNBC and correlates to unfavorable...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p‐tau217) in Alzheimer's disease (AD) remains uncertain. METHODS In this multi‐cohort study of 2117 individuals, we established baseline plasma p‐tau217 thresholds for amyloid‐β...

Global rice methane emissions tripled over six decades amid declining emission intensity

Abstract Rice paddies are among the largest anthropogenic sources of methane (CH4), yet substantial uncertainties persist in the long-term magnitude and spatiotemporal dynamics of the emissions. Here we show a spatially explicit global estimate of rice CH4 emissions from 1961 to...

The effects of norepinephrine infusion combined with goal-directed fluid therapy on delayed graft function in patients undergoing kidney transplantations: study protocol for a multicenter randomized controlled trial

Chronic kidney disease presents a formidable challenge to global healthcare systems. With ongoing advancements in surgical techniques, kidney transplantation has emerged as a principal therapeutic modality for individuals afflicted with end-stage renal disease, markedly enhancing...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

MOCR-DB: The Multi-Omics Causal Resource Database for Genetic Correlation, Causal Inference, and Functional Interpretation

Abstract Genome-wide association studies (GWAS) have revealed extensive polygenic signals and overlapping genetic architectures across human traits, creating a need for resources that connect trait-level genetic relationships with gene-level functional evidence. Here, we develope...

Patients’ perceptions of male and female nursing interns in Guangdong and Guangxi, Southern China

Nursing remains female-dominated globally, with gender stereotypes hindering workforce diversity. Male nurses account for 2% to 5% of China’s nursing workforce, and Guangdong/Guangxi lack studies on patients’ perceptions of male nursing interns. This study aims to explore relatio...

Jia (家) as a Primordial Phenomenon of Chinese Culture: Confucianism from the Perspective of Philosophical Anthropology

Faced with the crisis of self-orientation brought about by modernity, some Chinese scholars in recent years have taken jia 家 (family/home) as a core element of Confucian thought to construct a philosophy. This outlook seeks to open a possible path out of the predicament supporte...

scProtoTransformer: Scalable reference mapping across molecules, cells, and donors

Abstract The rapid accumulation of single-cell data has made it possible to comprehensively characterize biological systems at molecular, cellular, and donor levels. However, scalable reference mapping across different resolutions remains a major challenge in current research. He...

Advancing perioperative communication training in anesthesiology: an AIDET-informed simulation curriculum with preliminary local evaluation

Abstract Communication in anesthesiology is often compressed, high stakes, and emotionally charged, yet simulation in this specialty has traditionally focused more on technical or crisis-management skills than on clinician-patient-family communication. To address this gap, we dev...

A Wearable Multimodal Assistive Interface for Virtual Cursor Control in Stroke Survivors with Upper-Limb Impairment

Stroke survivors with upper-limb impairments often have difficulty using conventional computer interfaces, which limits their ability to perform daily computer-related activities independently. This study developed a wearable multimodal assistive interface that enables computer i...