Stanford University

P1.095. International Collaborative Study on the Relationship Between ALDH2 Gene Polymorphism and Changes in Salivary Acetaldehyde Concentration by L8020 Lactobacillus

Abstract Topic Esophageal Cancer: Esophageal Carcinogenesis Background Seventy-five percent of the world's esophageal cancer cases occur in Asia. The primary cause is the presence of the flasher (ALDH2 non-inactivating type). The ALDH2 gene polymorphism (rs671 G>A) is believed to...

Matrix stress relaxation drives glioblastoma cell response in viscoelastic biomaterials

The extracellular matrix (ECM) of glioblastoma (GBM) is known to modulate cell behavior, yet the specific contributions of matrix biochemical and biomechanical signaling remain poorly understood. To address this, we engineer a tunable hyaluronan-elastin-like protein (HELP) hydrog...

Empiric MRSA Coverage for Children with Osteoarticular Infections: 2015 to 2024

BACKGROUND AND OBJECTIVES Staphylococcus aureus is the most common causative pathogen for children with acute hematogenous osteomyelitis (AHO) and acute bacterial arthritis (ABA). National guidelines recommend empiric coverage for methicillin-resistant S. aureus (MRSA) at hospita...

Optimizing culture-free approaches to recover high-quality Mycobacterium tuberculosis genomic variation

Background. Mycobacterium tuberculosis ( Mtb ) genomic epidemiology often relies on culturing patient sputum, a time- and labour-intensive process. Hybrid capture approaches have been successfully used to enrich Mtb DNA from complex clinical samples, yet the accuracy of variant i...

Macrocyclization of Broad-Spectrum Kinase Inhibitor Bosutinib Leads to Potent and Selective Quinoline-Based HIPK4 Inhibitor AZ137

ABSTRACT Homeodomain-interacting protein kinase 4 (HIPK4) remains an understudied member of the dark kinome. While genetic knockout studies suggest roles for HIPK4 in spermiogenesis and cutaneous squamous cell carcinoma, whether these cellular functions can be recapitulated by ph...

Structural rearrangements underlying the activation of STIM1 by ER calcium depletion

ABSTRACT In resting cells, STIM1, the dimeric ER Ca 2+ sensor that controls store-operated Ca 2+ entry (SOCE), is held in a Ca 2+ -bound inactive state by multiple intramolecular restraints, or brakes. Receptor-evoked release of Ca 2+ from the ER causes a large conformational cha...

Retail Electricity Costs and Emissions Incentives Are Misaligned for Commercial and Industrial Power Consumers

Abstract Electrification is contributing to substantial growth in U.S. commercial and industrial loads, but the cost and Scope 2 carbon emission implications of this load growth are opaque for both power consumers and utilities. We present a comprehensive spatiotemporal data set...

Constraints on Large-Scale White Noise in the Cosmic Density Field

We present observational constraints on large-scale white noise (LSWN) in the cosmic density field, a phenomenon predicted to arise from nonlinear mode coupling during cosmological evolution. Building on the theoretical framework of our companion paper, where we demonstrated that...

Clinicians’ practices and attitudes toward depression assessment: a cross-sectional survey study

<title>Abstract</title> Accurate psychological evaluation is crucial for early detection, intervention and evaluation of mental health disorders. The validity and reliability of psychological evaluation methods have been systematically researched for many decades. However, assess...

Therapeutic remodeling of the tuberculosis granuloma with 1-methyl-D-tryptophan enhances CD8+ T cell-macrophage interactions.

T cell infiltration and reduces T cell activation and proliferation; and iii) therapeutic strategies, including D-1MT, that improve intragranulomatous killing hold strong translational potential.

The effects of CO2-rock interaction on the failure mode of clay-rich sandstone

Understanding how rock formations respond to CO₂ injection is critical for geological carbon storage. This study examines the impact of CO₂-rock interaction on the failure mode of clay-rich Tuscaloosa sandstone. To simulate CO₂-rock interaction in the subsurface, we conducted CO...

HarnessingDiamond Surface Features for Dense andAligned NV Ensembles

Abstract Controlling nitrogen doping in diamond is key to advancing nitrogen-vacancy (NV) center devices. We harness the hillock, a typically undesirable surface feature, to incorporate high densities of grown-in, aligned NV centers on a (001)-oriented substrate. Enhanced cathodo...

Cumulative Opioid Exposures in the First Year of Life and Cognitive Neurodevelopment in High-Risk Infants

BACKGROUND: High-risk infants with significant neonatal-perinatal morbidities often require opioids, but prolonged exposures can impair neurodevelopment. We evaluated the effect of cumulative opioid exposures in the first year of life, measured by morphine milligrams equivalents...

The gut microbiome and allograft outcomes: implications for heart transplantation

Heart transplantation remains the gold standard therapy for patients with end-stage heart failure. However, post-transplant complications are considerable. Emerging evidence implicates the gut microbiome as a modifiable determinant of post-heart transplant outcomes through its in...

Ancestry and Kawasaki Disease: Clinical Pathway Considerations

Kawasaki disease (KD) is the leading cause of pediatric acquired heart disease in developed countries.1 Despite decades of research, no established biologic marker has been identified, and KD remains a clinical diagnosis.1,2 However, KD research has shown that different populatio...

Streamlining analysis and design of two-dimensional electronic spectroscopy using machine learning

Two-dimensional electronic spectroscopy (2DES) offers unique insights into the coupling between electronic and nuclear motion and dynamics, making it a key technique in diverse fields, including materials science and biology. Obtaining 2DES data requires a series of measurements...

Valid Inference with Synthetic Data via Task Exchangeability: replication deposit

Replication deposit for the paper Valid Inference with Synthetic Data via Task Exchangeability (Lezhi Tan, Tijana Zrnic). Synthetic data is cheap to produce but can be biased, and treating it as real makes inference confidently wrong. Task exchangeability corrects for this: find...

DOSE: An open-source, iOS watch-based tool for experience sampling

Smartwatches facilitate low-burden rapid-access micro-interactions, making them ideal for Experience Sampling Methods (ESMs). Despite the Apple Watch being the most popular smartwatch in the U.S., it has yet to be utilized in ESM studies due to a lack of accessible frameworks tha...

Changes in Emergency Department Pediatric Readiness, Inpatient Services, and Excess Child Deaths

Importance Emergency department (ED) pediatric readiness and pediatric inpatient services have changed over time in many hospitals, but the impact of these changes on pediatric outcomes is unclear. Objective To evaluate pediatric mortality associated with changes to ED pediatric...

Algebraic characterization of equivalence between oracle-based iterative algorithms

Abstract When are two algorithms the same? How can we be sure a recently proposed algorithm is novel, and not a minor variation on an existing method? In this paper, we present a framework for reasoning about equivalence between a broad class of iterative algorithms, with a focus...