Sorbonne Université

Evolutionary dynamics and functional refinement of IGF bioavailability in the vertebrate phylum : focus on IGFBPs

In eutherians, Insulin-like Growth Factor-I (IGF-I) and IGF-II exert insulin-like activity by interacting with type-I receptor. IGF bioavailability is finely regulated by six IGF-Binding Proteins (IGFBPs), IGFBP-1 to -6, which bind IGF-I and -II with high affinity but not insulin...

The Cold-Air Outbreaks in the Marine Boundary Layer Experiment model-observation intercomparison project (COMBLE-MIP) – Part 1: Model specification, observational constraints, and preliminary findings

Models struggle to represent the coupled microphysical, turbulent and radiative processes within widespread, long-lived marine cold-air outbreak (CAO) cloud fields, contributing to forecast and climate biases. Here we combine ground-based and satellite measurements to initialize...

New record and description of a male Murina kontumensis (Kon Tum Tube-nosed Bat) from Vietnam

Abstract The Kon Tum Tube-nosed Bat ( Murina kontumensis Son et al. 2015. A new species of the genus Murina (Chiroptera: Vespertilionidae) from the Central Highlands of Vietnam with a review of the subfamily Murininae in Vietnam. Acta Chiropterol. 17: 201–232) was described from...

Underground Signals: The Ecological Power of Root Volatiles

Root volatiles mediate diverse belowground interactions among plants, microbes, and invertebrates, but biological and environmental conditions strongly influence their production, movement, perception, and ecological effects. This review synthesizes current knowledge through an i...

JuRa: The Juventas Radar on Hera Mission to Probe Internal Structure of Didymos and Dimorphos Asteroids

Abstract JuRa, the Juventas Radar, is the sounding radar of the Hera/ESA mission on cruise to the asteroid Didymos and its moon, Dimorphos. In 2027, it will, for the first time, do direct observation of the internal structure of an asteroid for the benefit of both science and pla...

Overcoming Sampling Limitations Using Machine-Learned Interatomic Potentials: The Case of Water-in-Salt Electrolytes

Abstract Machine-learned interatomic potentials hold the promise to enable the modeling of highly concentrated liquids over meaningful time scales, far from reach for current ab initio electronic structure methods. Here we evaluate the performances of various MACE potentials in m...

Prenatal findings and postnatal outcomes in cases of closed spinal dysraphism: 10‐year two‐center cohort study

OBJECTIVE: To characterize prenatal ultrasound findings in fetuses with prenatally diagnosed closed spinal dysraphism (CSD) and report their postnatal management and functional outcomes at 18 and 36 months. METHODS: This retrospective cohort study included all fetuses with a pren...

Lenalidomide maintenance after initial immunochemotherapy in chronic lymphocytic leukaemia—Final analysis of the international phase III CLL6 RESIDUUM study of the ALLG and FILO groups

Summary Most patients treated for chronic lymphocytic leukaemia (CLL) fail to achieve measurable residual disease (MRD) negativity. The role of maintenance with the immunomodulatory drug lenalidomide in these patients is unclear. A randomised multicentre phase III trial (ACTRN126...

Carbon solubility and liquid–liquid immiscibility in Fe–C–S ternary system up to 6 GPa: implications for the core of small planetary bodies

Abstract High-pressure, high-temperature experiments were conducted in a multi-anvil press using seven different starting compositions to investigate the phase relations of Fe–C–S liquids at pressures up to 6 GPa and temperatures up to 2000 K. Quenched samples revealed immiscible...

Anti-thymocyte globulin triggers TNF-dependent cell death in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) accounts for one of the most aggressive hematological tumors associated with poor prognosis, notably for relapsed and refractory patients. Hence, an unmet medical need persists for T-ALL patients who fail to durably respond to conventio...

Co-design of a wheelchair-mounted robotic arm for functional autonomy: a Cybathlon case study in user-driven assistive robotics

Abstract Background Wheelchair-mounted robotic arms may support functional autonomy for individuals with upper-limb disabilities, but their long-term usability remains limited by the difficulty of matching high-dimensional robotic control to heterogeneous motor capabilities, dail...

Sex-related variability of white-matter tracts is robust to tractography methodology

Abstract Diffusion tractography is the prominent in-vivo technique to study and investigate white-matter pathways in the human brain. While tractography is a powerful method, recent work suggests that different tractography methods can produce strikingly different representations...

Lifetime exposure to atypical working hours among healthcare professionals compared with the workforce in other sectors: Nationwide cohort study

Background Despite well-documented health risks, cumulative exposure to atypical working hours (AWH) over a career remains poorly quantified, especially among healthcare workers. Objectives This study aimed to compare career-long AWH exposure among healthcare professionals and ot...

A memory of Paleozoic to Quaternary Greenhouse climates recorded in Southern African regolith

Abstract In this article, we explore the potential of iron-rich duricrust regoliths from old erosional anorogenic surfaces to record clues of the long-term continental paleoclimatic evolution. We coupled geochemical, mineralogical and geochronological analyses on iron oxides and...

Optimizing the Ocular Surface Before, During, and After Glaucoma Surgery: A Narrative Review

This narrative review synthesizes the published literature on ocular surface disease (OSD) and glaucoma filtration surgery to develop practical, evidence-informed clinical and surgical recommendations for optimizing ocular surface management before, during, and after surgery. The...

Vascular Imaging Features and Time-Specific Recurrence Risk After Craniocervical Artery Dissection

Background and ObjectivesCraniocervical artery dissection (CCAD) is a major cause of stroke in young adults, yet its recurrence risk remains poorly defined because of delayed enrollment in prior research. We aimed to determine the temporal distribution of recurrent ischemic strok...

Extending the ATP9A ‐Related Phenotypic Spectrum: Indication of Schizophrenia Susceptibility

ABSTRACT ATP9A, which belongs to the P4‐ATPase family of proteins, is involved in the efficient transport of vesicles from the Golgi apparatus to the plasma membrane, as well as the release of extracellular vesicles from human cells. In 2021, a loss‐of‐function variant of this ge...

Distinct migratory dendritic cell subsets cooperate to prime tissue-resident memory-like CD8⁺ T cells in mouse tumors

Tumor-infiltrating tissue-resident memory (TRM)-like CD8+ T cells correlate with positive prognosis and better responses to cancer immunotherapy, yet the mechanisms underlying their specification remain ill-understood. Here, we use the KP (KrasG12D, p53-/-) mouse model of lung ad...

Ultrahigh flow strength in shocked nanopolycrystalline diamond

Extreme pressures and temperatures create conditions that allow even hard and brittle materials to flow plastically. Despite extensive research, the limits of flow strength under such conditions remain uncertain, and the mechanisms driving deformation at the relevant stresses are...

Paler within the city: Carotenoid‐based colouration covaries negatively with the proportion of impervious surface in great tit ( Parus major ) territories across Europe

Urbanisation alters resource availability and exposes wildlife to novel environmental stressors, potentially driving phenotypic divergence. Carotenoid-based plumage colouration is a condition-dependent trait linked to dietary carotenoid acquisition and physiological allocation tr...