Sorbonne Université

Statistical discrimination of Guatemalan jadeitite sources using LA-ICP-MS trace element and petrological data

While tracing the geological provenance of Maya jadeitite-jade is key to understanding Mesoamerican exchange and extraction, distinguishing between the north (NMM) and south (SMM) Motagua sources presents significant challenges. This difficulty is due to shared mineralogical trai...

Zoological biobanks as a resource for microplastic analysis: a Py-GC-MS/MS case study on sea cucumbers

Microplastics have spread through every ecosystem studied. Yet, documenting their spatiotemporal distribution remains challenging, particularly in marine environments where sampling is costly and difficult. Archived specimens in zoological biobanks offer an underused resource for...

An energetic perspective on the impact of the Atlantic Multidecadal Variability on the West African Monsoon

Abstract. This study explores mechanisms by which the Atlantic Multidecadal Variability (AMV) drives multidecadal changes in the West African Monsoon (WAM), with a focus on Sahel rainfall. We investigate this connection through an energetic perspective using atmosphere-ocean coup...

Safety and Performance of the Colovac Anastomosis Protection Device. A Pooled Analysis of Prospective Studies Compared With Diverting Loop Ileostomy (SAFE-2025)

Objective: To compare the safety and effectiveness of the Colovac Anastomosis Protection Device with standard diverting ostomy (DO) following low anterior resection (LAR) for rectal cancer. Summary Background Data: DO is standard of care (SOC) following LAR for rectal cancer but...

Paleoenvironmental and paleoclimatic reconstruction in the Western Mediterranean during the Late Early Pleistocene

Abstract. The major climate change recorded during the Early-Middle Pleistocene Transition (1.4–0.4 Ma) is characterized by an increase in the length of climatic cycles from 41 to 100 ka. During this period, the Mediterranean climate underwent aridification associated with a drop...

Shared Hyperphagia phenotypes and variable response to semaglutide in adults with neurodevelopmental obesity

Adults with neurodevelopmental disorders (NDD) are at high risk of developing obesity, yet systematic evaluations of their eating behavior profiles remain scarce. In this study, participants were adults with overweight or obesity associated with a genetically confirmed NDD with i...

Septin architecture dictates size-dependent diffusion barriers on biomimetic membranes

Abstract Septins are cytoskeletal filaments bound to the inner leaflet of the plasma membrane, essential for cell division. They are involved in the formation of diffusion barriers for membrane-bound components. Whether septins directly function as barriers or as part of a broade...

The algebraic structures of social organizations: the operad of cooperative games

The main goal of this paper is to settle a conceptual framework for cooperative game theory in which the notion of composition/aggregation of games is the defining structure. This is done via the mathematical theory of algebraic operads: we start by endowing the collection of all...

Calpain inhibition prevents high-glucose-induced autophagy blockade and mitochondrial fragmentation in endothelial cells and preserves vascular functions in diabetic mice

Endothelial dysfunction is a major contributor to diabetic vascular complications, yet the mechanisms linking hyperglycemia to impaired endothelial homeostasis remain insufficiently defined. This study identifies calpains as key regulators of endothelial autophagy and mitophagy u...

Life finds its way in seaports: environmental DNA monitoring in the Grand Port Maritime de Guadeloupe shows vertebrate richness but reduced phylogenetic diversity

Abstract Ports are increasingly recognized as distinct urban marine ecosystems (UME) shaped by intense human activities, yet their biodiversity remains poorly documented, particularly in tropical regions. Environmental DNA (eDNA) metabarcoding offers a powerful, non-invasive appr...

Learning behaviour is consistent across time and tasks in Formica fusca ants

Abstract Research on interindividual behavioural and cognitive variability has gained momentum over the last few decades. Most studies focused on vertebrates, revealing that individual cognitive performance can be stable across time and tasks and linked to other behavioural trait...

Necessary Conditions for Shock Solutions to a Hyperelastoplastic Model

We propose a formulation of hyperelastoplasticity such that one can pass to the limit regime of rate-independent plasticity. It results in a family of modified entropy inequalities. A key ingredient is the Hencky logarithmic plastic tensor. A discussion of possible shock solution...

Design and analytical validation of Nexthyro 2.0, a custom next-generation sequencing panel integrating DNA mutation profiling and RNA fusion detection for routine thyroid pathology specimens

Abstract The increasing role of molecular testing in thyroid pathology, from the pre-operative stratification of indeterminate fine-needle aspiration (FNA) categories to the management of advanced carcinomas, has prompted the development of institution-specific custom NGS solutio...

Poincaré inequality and quantitative De Giorgi method for hypoelliptic operators

We propose a systematic approach based on trajectories to prove a Poincaré inequality for weak non-negative sub-solutions to hypoelliptic equations with an arbitrary number of Hörmander commutators, both in the local and in the non-local case. As a consequence, we deduce the weak...

Effects of Evolocumab on Mortality Outcomes in Patients Without Previous Myocardial Infarction or Stroke: A Prespecified Analysis of the VESALIUS-CV Randomized Clinical Trial

BACKGROUND: Evolocumab, a PCSK9 (proprotein convertase subtilisin–kexin type 9) inhibitor, significantly reduced the risk of cardiovascular events in patients without previous myocardial infarction or stroke in the VESALIUS-CV trial (Effect of Evolocumab in Patients at High Cardi...

Optimising bat-friendly curtailment algorithms for wind turbines

Wind turbines worldwide cause high mortality in long-lived bats through collisions. To mitigate these impacts, operators commonly apply blanket curtailment by stopping turbine blades under low wind speed and mild temperature, when bat activity is often high and energy production...

Stable tissue oxygen cerebral perfusion pressure (stoCPP): Proof of concept for a novel method for the assessment of optimum cerebral perfusion pressure in severe traumatic brain injury

Abstract To demonstrate a method for the identification of safe cerebral perfusion pressure (CPP) in patients with severe traumatic brain injury using brain tissue oxygen (PbtO₂) readings as a surrogate marker of cerebral blood flow. Retrospective analysis of prospectively collec...

LDL Cholesterol Lowering With Evolocumab Before Percutaneous Coronary Intervention for Acute Myocardial Infarction

Importance: Proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibition is recommended as second- or third-line lipid-lowering therapy after myocardial infarction (MI), resulting in prolonged periods of inadequate low-density lipoprotein cholesterol (LDL-C) control. Whether...

FastCNV: fast and accurate copy number variation prediction from high-definition spatial transcriptomics and scRNA-seq data

Abstract Background Predicting DNA copy number variations (CNVs) from spatial transcriptomics (ST), including Visium HD, or single-cell RNA-sequencing (scRNA-seq) data helps to distinguish malignant from non-malignant cells and to characterize the clonal architecture of tumor cel...

Evaluating the Validity of Model Organisms: A Review and a New Framework for Biologists

Model organisms are central to biological research. Living organisms are models in the sense that the knowledge gained from their study is meant to be generalized. For example, experiments conducted on Drosophila or nematodes bring general knowledge on phenomena such as cell migr...