Sorbonne Université

Visible mould and blood inflammatory phenotypes of asthma in adults: the CONSTANCES cohort

Studying the associations between indoor mould contamination and blood inflammatory phenotypes may provide further insight into the mechanisms by which this environmental factor affects asthma. Among 1870 adults with current asthma from a population-based cohort, 29.6% reported v...

Guidelines for Studying Mutagenesis in Quiescent Schizosaccharomyces pombe

All living organisms can enter a non-dividing state known as quiescence, which often functions as a survival strategy. In many cases, quiescent cells retain the ability to re-enter the cell cycle when conditions become favorable. Therefore, preserving the integrity of non-dividin...

A dependency map enhanced with next-generation 3D cancer models

Despite advances in precision oncology, effective personalized treatments are still lacking for most patients with cancer1. The Cancer Dependency Map (DepMap) accelerates this field by systematically identifying cancer vulnerabilities in diverse preclinical models. Data from over...

The rise of carnivoran mammals in Europe through the lens of body mass

Carnivoran mammals (cats, dogs, bears, seals, etc.) and their kin radiated during the Palaeogene, among other carnivorous clades (hyaenodonts, mesonychians, and oxyaenodonts). This radiation has often been framed as a competition ultimately won by carnivorans, but the data suppor...

Labyrinthula merlionensis sp. nov.: A Novel Labyrinthulid Infecting Marine Diatoms

Labyrinthulomycetes are a class of fungus-like heterotrophic protists from the Stramenopiles lineage, recognized for their ecological role as decomposers and contributors to nutrient cycling. They colonize various substrates, from seaweed to terrestrial environments, utilizing ec...

CO 2 ‐to‐CO Electrochemical Conversion With an Fe(I) Porphyrin Complex in Water

ABSTRACT Iron porphyrin complexes constitute a well‐established and versatile class of molecular electrocatalysts for the reduction of CO 2 to CO. In both organic and aqueous media, the reaction mechanism is typically proposed to involve the interaction of CO 2 with a formally de...

Fertility-Sparing Management of Atypical Hyperplasia and Endometrial Cancer from the Perspective of Molecular and Hormonal Profiles: A Meta-Analysis-Driven Framework

Background/Objectives: The prognostic and predictive values of biomarkers in fertility-sparing management of atypical hyperplasia (AH) and endometrial cancer (EC) remain ill-defined. We aimed to identify the impact of tumour profiles on oncologic and reproductive outcomes to info...

Agronomic and socio-economic assessments of the roles of earthworms and termite mounds in paddy fields

Bioturbation, the physical disturbance and mixing of soil layers caused by the activity of living organisms, such as earthworms and termites, plays a critical role in shaping soil structure, enhancing nutrient cycling, and regulating ecosystem dynamics. In paddy fields, earthworm...

Listening to the Silent Patient: Toward Continuous Detection of Dyspnea During Mechanical Ventilation

Maxens Decavèle, MD. PhD, Alexandre Demoule, MD. PhD; Listening to the Silent Patient: Toward Continuous Detection of Dyspnea During Mechanical Ventilation

Chemical desorption of methanol induced by hydrogen abstraction–addition cycles on cold grain surfaces

Abstract We report ultra-high vacuum experiments on the non-thermal desorption of methanol (CH3OH) from cold dust-grain analogues under hydrogen-atom bombardment. Monolayer methanol films on polycrystalline gold, compact amorphous solid water (ASW, 10 ML) and 13CO ice (2 ML) are...

Topologically Engineered DNA Origami: Responsive Locking of DNA Quadrilateral for Biosensing Application

Abstract DNA nanotechnology offers unique opportunities for creating various accurate and responsive nanostructures. Nevertheless, large-scale conformational changes with high geometric precision and efficiency remain major challenges. Herein we report a topologically engineered...

Serum Glial Fibrillary Acidic Protein Dynamics, Disease Progression, and Therapy Response in Multiple Sclerosis

Importance: Capturing individual multiple sclerosis (MS) progression is difficult; few studies have evaluated glial fibrillary acidic protein (GFAP) in large longitudinal cohorts with independent validation. Objective: To investigate whether serum GFAP levels and treatment-relate...

Multi‐Scale Investigation of Supramolecular Organogels Assembled From Pt(II)‐Salphen Complexes

Supramolecular metallogels based on platinum(II) complexes have attracted growing interest due to their tunable photophysical properties. However, the potential of Pt(II)-salphen complexes as low-molecular-weight gelators remains largely unexplored. Here, we report a series of Pt...

FGFR3-driven gene regulatory network analysis reveals a protumoral role for p63 in luminal bladder tumors

Fibroblast growth factor receptor 3 ( FGFR3 ) is one of the most frequently altered genes in bladder cancer, primarily through activating mutations that drive oncogenesis and are enriched in luminal tumors. However, the underlying gene regulatory network (GRN) remains poorly char...

Analysis of bone metastasis multidisciplinary team meeting activity in a university hospital: patient profiles, prognostic factors

Bone metastases a represent a challenge in the oncological management of patients as the complications can be severe, as fractures or neurological impairment in spinal metastases. Recommendations on the management of bone metastases are constantly being improved. However, there a...

Alcohol and tobacco in cancer: A unified framework of interaction across carcinogenic pathways and cancer types

Background Alcohol and tobacco are among the leading preventable causes of cancer worldwide and frequently co-occur. While both are well-established independent carcinogens, their combined effects remain insufficiently characterized and inconsistently interpreted across cancer ty...

Genetic screening identifies WNT5A/RYK as a determinant of extracellular vesicle fate

Extracellular vesicles (EVs) are natural mediators of intercellular communication through the transfer of cytoplasmic material from donor to recipient cells. The molecular mechanisms governing EV uptake and cargo delivery in recipient cells remain largely elusive. To address this...