Radboud University Nijmegen

Evaluation of nationwide variation in post-haemorrhagic ventricular dilatation management following national guideline implementation in the Netherlands

Abstract Purpose Post-haemorrhagic ventricular dilatation (PHVD) is a severe complication of germinal matrix–intraventricular haemorrhage in preterm infants and is associated with significant morbidity and adverse neurodevelopmental outcomes. In 2023, national recommendations for...

Strategies to Improve Project Results Using Relational Capital in Agile and Hybrid Agile Software Development

ABSTRACT Improvements in Agile and Hybrid Agile project management hold immense potential, promising significant cost savings. These methodologies place the customer at the center of the software development process, providing valuable business insights and offering feedback, val...

The Temporal Effects of Meaningful and Pleasurable Activities on Affective Wellbeing and Stress: Insights from an Experience Sampling Study

Abstract Pleasurable activities enhance affective wellbeing, but potentially only briefly, whereas meaningful activities may have a more enduring effect on affective wellbeing. To explore these dynamics, we examined how meaningful and pleasurable activities impact momentary and l...

Sport, exercise, and physical activity in children with cardiovascular disease. A Clinical Consensus Statement of the European Association of Preventive Cardiology (EAPC) of the ESC, the Association of Cardiovascular Nursing & Allied Professions (ACNAP) of the ESC, and the Association for European Paediatric and Congenital Cardiology (AEPC)

Regular physical activity offers numerous benefits to children's health and well-being and is essential for reducing cardiovascular risk in children with cardiovascular disease. Despite increasing evidence supporting its benefits, many young patients remain insufficiently active...

Interferon-enhanced cytokine responsiveness in early trauma-induced immune dysfunction: a prospective observational pilot study

Severe trauma induces profound alterations in innate and adaptive immunity within hours after injury, which may contribute to increased susceptibility to secondary infections and adverse outcomes. While trauma-associated immune dysfunction has been extensively described, little i...

Weight management in cardiology practice: challenges and opportunities

Abstract Obesity poses a clear challenge to the cardiovascular landscape. In this viewpoint, we advocate that we need to prepare for the practical implementation of weight management in Dutch cardiology practice by 1) educating ourselves and our peers on obesity and its treatment...

Land Triadic Nexus: A conceptual framework for land governance through the strategic adaptive alignment of land use, rights, and values

Land governance persistently fails to achieve its stated objectives, producing unintended outcomes, coordination failures, and inequality. This paper argues that a major reason is the treatment of land use, land rights, and land value as parallel administrative domains rather tha...

Meta-ethnography and policy effectiveness: an Evidential Pluralism perspective

Abstract Evidence-based policy is typically grounded in a narrow conception of evidence, one that prioritises comparative studies and quantitative meta-analyses as the preferred base for establishing causal claims. However, this prevailing theory of evidence—often implicitly adop...

Menopause hormone therapy in women with cardiovascular risk factors or established ischemic heart disease: A joint FIGO and WHF position paper

Extending women's health-span is a key challenge for the medical community. Although women live longer than men, they face a higher burden of chronic diseases, such as cardiovascular diseases (CVDs) and disabilities. Endogenous estrogens appear to benefit cardiovascular health, a...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Retinalysis-Vascx: An Explainable Software Toolbox for the Extraction of Retinal Vascular Biomarkers From Color Fundus Images

Purpose: Automatic extraction of retinal vascular biomarkers from color fundus images (CFIs) is crucial for large-scale studies of the retinal vasculature. We present VascX, an open-source software toolbox that extracts biomarkers from CFI artery-vein segmentations. Methods: From...

RCC-AID: Renal Cell Carcinoma AI Dataset for Medical Imaging Research

Contrast-enhanced computed tomography (CT) is central to the diagnosis, staging, and follow-up of patients with renal cell carcinoma (RCC). As artificial intelligence research into computer-aided solutions continues to grow, the need for curated and annotated datasets becomes inc...

A multicenter randomized, double-blinded placebo-controlled phase 2 trial to evaluate safety and efficacy of ilofotase alfa in patients at risk for kidney injury following open heart surgery

Acute impairment of kidney function after cardiac surgery is common and associated with an increased morbidity and mortality. Ilofotase alfa has demonstrated potential to attenuate renal injury through its immunomodulatory effects. We evaluated the safety and efficacy of ilofotas...

Dosing and delivery of bacteriophage therapy in a murine wound infection model

Lytic bacteriophages, viruses that lyse (kill) bacteria, hold great promise for treating infections, including wound infections caused by antimicrobial-resistant Pseudomonas aeruginosa. However, dosing and delivery strategies for phage therapy remain underdeveloped. In a mouse wo...

Relationship Breaker? Unplanned Births and Relationship Dissolution

This study explores the association between unplanned pregnancies resulting in a birth and relationship dissolution in the Netherlands. Using prospective, population-based birth cohort data from Rotterdam, the second largest city in the Netherlands, it finds that couples with an...

The development and application of the integrative framework of feasibility and process of change of mindfulness-based interventions

Abstract A substantial number of qualitative studies have been conducted on feasibility and process of change of Mindfulness-Based Interventions (MBIs), but differences in terminology makes results of these studies difficult to compare. We conducted a targeted focused literature...

Practice variation in hospital care for pelvic organ prolapse and urinary incontinence: an analysis of specialists’ expectations, cross-sectional claims data, and the role of clinical guidelines

Abstract Background Pelvic floor disorders, specifically pelvic organ prolapse and urinary incontinence, are highly prevalent conditions that exhibit substantial practice variation. This study aims to examine the relationship between clinical practice guidelines and practice vari...

Niche-specific immune and microbial signatures across the healthy upper respiratory tract mucosa

Host-microbe interactions in the upper respiratory tract (URT) niches that form the first line of defense against respiratory infections are incompletely understood. We profiled immune and microbial features using minimally invasive samples from 44 healthy adults (20–65 years), i...

Exercise-based cardiac rehabilitation for coronary heart disease

RATIONALE: Coronary heart disease (CHD) is the leading cause of death globally. CHD mortality rates remain steady in low- and middle-income countries but are declining in high-income countries, meaning more people are living with CHD and need support to manage their symptoms and...

Neural responses during natural vision are action-timed rather than locked to the onset of stable foveal input

Visual processing is traditionally studied using static viewing paradigms in which researchers analyse brain responses to the onsets of a sequence of randomly selected stimuli. Translating this “stimulus onset” approach to active vision paradigms that allow for free eye-movements...