Radboud University Nijmegen

Frequency and laminar profile of feature-specific visual activity revealed by interleaved EEG–fMRI

Abstract The role of cortical oscillations in brain function has been extensively debated, resulting in a variety of theoretical frameworks. Using inter-leaved simultaneous EEG-fMRI, we examined the layer-specific relationship between oscillatory activity and visual processing. W...

The Scolioscoop® V3: A low-tech self-assessment tool for patients with adolescent idiopathic scoliosis

Abstract Background Adolescent idiopathic scoliosis (AIS) requires follow-up during growth to detect progression, resulting in a burden of care. The Scolioscoop ® V3 was developed as an alternative to the Bunnell Scoliometer, to facilitate home monitoring by parents/caregivers. A...

Evasiveness in Everyday Hospital Palliative Care Practice: A Focused Ethnography

ABSTRACT Aim To develop a practice‐based understanding of how everyday hospital routines, professional norms and organizational conditions influence the provision of palliative care for patients approaching the end of life. Design Focused ethnography informed by practice theory....

Evolution of dipole-dipole dynamics in cold ammonia collisions

Data for submission of "Evolution of dipole-dipole dynamics in cold ammonia collisions" Authors: Yao Chang1, Andr´e J.A. van Roij1, Stach Kuijpers1, Sven Herbers, Etienne F. Walraven1,Tijs Karman1∗∗, Sebastiaan Y.T. van de Meerakker1∗∗1Radboud University, Institute for Molecules...

Dynamic Functional Synchronization Profiles in Autism Differ by Spatial Scale and Along Hierarchical Cortical Gradients.

Background: Prevailing theories propose that autism is characterized by local cortical overconnectivity and long-range underconnectivity, but empirical evidence remains mixed. Methods: = 1009) to examine how functional synchronization profiles dynamically change over time and acr...

The effect of proximity of COVID-19 test facilities on test uptake: two quasi-experimental trials

Access to testing sites is a critical component in reducing the spread of a virus during infectious disease outbreaks. For example, distance to the testing site has been mentioned as an important self-reported barrier for test uptake during the COVID-19 pandemic. Despite its impo...

Oral health and systemic health outcomes: A call for interdisciplinary action

Abstract Objectives To make the case, from periodontology and dental public health, for interdisciplinary action on oral and systemic health, and to set out recommendations for practice, policy, education, and research. Materials and Methods A joint working group of the European...

Antithrombotic therapy after percutaneous coronary intervention in patients with atrial fibrillation: an individual patient data network meta-analysis

BACKGROUND AND AIMS: Randomized trials demonstrated that in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) direct oral anticoagulants (DOAC) and a P2Y12 inhibitor reduce bleeding compared with vitamin K antagonist (VKA) plus dual antipl...

Time-dependent prognostic value of coronary plaque burden and hyperemic myocardial blood flow

Abstract Rationale The time-dependent contributions of coronary atherosclerotic plaque burden and myocardial ischemia to clinical outcomes in suspected coronary artery disease (CAD) remain uncertain. This study aimed to evaluate the temporal associations of quantitatively assesse...

Transition from mandatory to discretionary nurse-measured MEWS assessment in a continuously monitored surgical ward: Diagnostic performance of wearable-derived early warning scores

Abstract Early detection of clinical deterioration on surgical wards is vital to prevent adverse outcomes. Conventional ward monitoring using the Modified Early Warning Score (MEWS) relies on intermittent nurse-measured vital signs, but its role may change when continuous wearabl...

The identification of a PRKACA duplication at 19p13.12 in a female with PPNAD and thyroid carcinoma after a 20-year diagnostic journey

Abstract Rare pathogenic variants affecting components of the evolutionary conserved cAMP/protein kinase A (PKA) signalling pathway are implicated in a spectrum of adrenocortical disorders. Germline inactivating PRKAR1A variants leading to constitutive PKA activation, underlie pr...

Stress‐induced trained immunity—A key mechanism linking psychosocial stress, atherosclerosis, and cardiovascular disease

Although chronic psychosocial stress is a well-established independent risk factor for cardiovascular disease (CVD), the underlying mechanisms linking stress to CVD remain incompletely understood. Here, we review clinical and preclinical research documenting how stress can activa...

ACPC-MAP: a protocol for manually aligning structural T1-weighted magnetic resonance images to the anterior commissure – posterior commissure plane according to clinical standards

Abstract Realigning structural MR images to stereotactic AC-PC space is a standard procedure that enhances anatomical consistency both within and across neuroimaging studies, allowing for precise spatial localization and reliable cross-subject comparisons in both clinical and res...

Can Organic Amendments Override Environmental Filtering of Soil Microbiomes? Evidence From 20 Years Old Agricultural Field Trials in Contrasting Tropical Sites

ABSTRACT Soil microbial communities underpin ecosystem functions critical for sustainable agriculture, yet our understanding of how long‐term management of tropical agroecosystems shapes these communities remains limited. This is particularly the case in sub‐Saharan Africa where...

From policy debate to empirical evidence: a proof-of-concept bibliometric and LLM-assisted abstract-level content analysis of OTC hearing aid research before and after FDA regulation

Objective To characterise temporal patterns in over-the-counter (OTC) hearing-aid research before and after U.S. Food and Drug Administration (FDA) implementation of the OTC category (effective October 2022), using bibliometrics and large language model (LLM)–assisted abstract-le...

Expected costs and benefits of genetic counselling and germline genetic testing in metastatic prostate cancer

Abstract Identifying pathogenic germline variants in men with metastatic prostate cancer is important for therapeutic options and for identifying relatives who may have a high cancer risk. To keep genetic testing costs manageable, it is important to identify which patients should...

Placebo Analgesia Does Not Generalize From Pain to Interoceptive Abilities: A Preregistered Exploratory Study

Placebo pills reliably reduce pain. Pain perception is tied to increased arousal and heart rate. Heart rate perception is, in turn, closely related to interoceptive signals processing, for example, pain and autonomic regulation. However, no studies so far have systematically exam...

Milvexian with Antiplatelet Therapy after Acute Coronary Syndrome Event

BackgroundPatients are at increased risk for recurrent ischemic events after an acute coronary syndrome event. Milvexian, an oral factor XIa inhibitor, may reduce the risk of major adverse clinical events with minimal bleeding risk. MethodsIn this phase 3, randomized, placebo-con...

Ritualization of euthanasia in cases of unbearable psychiatric versus unbearable somatic suffering in the Netherlands: a comparison

The Netherlands has an established euthanasia practice. The increase in euthanasia cases for psychiatric suffering over the past 10 years is subject to ongoing public and political debate. During the fieldwork of the research project “ritualisation of euthanasia”, remarkable diff...

Long-term outcomes of childhood ADHD stimulant use trajectories

Background. Stimulant medication is the first-line pharmacological treatment option for children with attention-deficit/hyperactivity disorder (ADHD). However, long-term effects remain unclear. Therefore, we explored long-term (>12 years) outcomes of childhood stimulant medicatio...