Radboud University Nijmegen

Niche-specific immune and microbial signatures across the healthy upper respiratory tract mucosa

Host-microbe interactions in the upper respiratory tract (URT) niches that form the first line of defense against respiratory infections are incompletely understood. We profiled immune and microbial features using minimally invasive samples from 44 healthy adults (20–65 years), i...

Neural responses during natural vision are action-timed rather than locked to the onset of stable foveal input

Visual processing is traditionally studied using static viewing paradigms in which researchers analyse brain responses to the onsets of a sequence of randomly selected stimuli. Translating this “stimulus onset” approach to active vision paradigms that allow for free eye-movements...

Exercise-based cardiac rehabilitation for coronary heart disease

RATIONALE: Coronary heart disease (CHD) is the leading cause of death globally. CHD mortality rates remain steady in low- and middle-income countries but are declining in high-income countries, meaning more people are living with CHD and need support to manage their symptoms and...

Interplay between diaphragm thickening, force generation and lung volume change: a physiological study in health and diaphragm weakness

Introduction Diaphragm ultrasound is increasingly used to assess diaphragm function. Diaphragm thickening (DTF) is widely interpreted as a surrogate of diaphragm force generation. However, the independent contributions of force generation and lung volume change to diaphragm thick...

Navigation Bronchoscopy Specific Cone-Beam CT Software Enabling Pre- And Intraprocedural Guidance

BACKGROUND: Cone-beam computed tomography (CBCT)- guided bronchoscopy is an established technique for diagnosing peripheral pulmonary lesions, offering 3-dimensional imaging for both navigation and confirmation. However, its usability as a stand-alone modality is limited by a sub...

Blended Care in the mCIMT-BiT Pirate Group in Children with Unilateral Cerebral Palsy: A Feasibility Study

Aims Intensive upper limb rehabilitation is essential for children with unilateral cerebral palsy (uCP). Home-based training may extend practice opportunities and reduce logistical barriers. This study examined the feasibility of a blended care approach in the mCIMT-BiT Pirate gr...

Two-year impact of a bundled payment program for total hip or knee replacement in the Netherlands: a difference-in-differences analysis

Abstract Background In 2018, a Dutch health insurer introduced a bundled payment program for total hip or knee replacement (THKR). Participating hospitals shared in savings and losses per episode, covering all THKR-related hospital care, including complications within one year af...

Temporal evolution of vessel wall abnormalities in young ischemic stroke – the ODYSSEY study

INTRODUCTION: We examined the temporal patterns of vessel wall (VW) lesions on high-resolution MRI (HR-MRI) in a cohort of young stroke survivors. STUDY AND METHODS: This substudy of the ODYSSEY is a single-center prospective cohort study comprising participants aged 18-50, who e...

Model-based estimation of the population contrast response function in human visual cortex

Contrast determines how strong visual stimuli drive neural responses and, in turn, how well we can see. This contrast-response relationship is nonlinear, with gain control mechanisms acting to compress responses to high-contrast stimuli, effectively setting the contrast range tha...

Gas absorption of soft X-rays strongly impacts the redshift distribution of dark Fast X-ray Transients

Abstract The progenitors of many Fast X-ray Transients (FXTs) and those of γ-ray bursts (GRBs) are strongly linked. Given that ”dark” GRBs are typically found to be events suffering from enhanced extinction in the host galaxy, we investigate the nature of ”dark” FXTs. However, un...

A Pontryagin class obstruction for purely electric and purely magnetic Weyl curvature tensors

Abstract Do all manifolds that admit Lorentzian metrics also admit such metrics that have a purely electric (PE) or purely magnetic (PM) Weyl curvature tensor? To (partially) answer this question, we show that for all algebraic curvature tensors on a 4 k -dimensional scalar produ...

Low Postoperative Cholesterol Level Is Associated with Adverse Outcomes After Coronary Artery Bypass Grafting

Low cholesterol levels have been linked to severe illness, including sepsis. This study evaluated whether early postoperative cholesterol levels are associated with adverse outcomes in patients after elective Coronary Artery Bypass Grafting with extracorporeal circulation. This r...

A longitudinal study on how trust shapes psychological reactance to the German measles vaccine mandate

Abstract Background Vaccine mandates can increase uptake, yet their psychological effects remain underexplored. Psychological reactance theory suggests that mandates may prompt resistance and reduce acceptance of voluntary vaccination. We examined changes in reactance and attitud...

Associations of frailty and COVID-19 severity with long-term health outcomes of COVID-19 among older people

To investigate whether frailty and COVID-19 severity are associated with long-term health outcomes of COVID-19 in older people. In this cohort study, older people aged ≥ 70 years with COVID-19 between January 2020 and December 2021 were invited for follow-up. Participants were re...

Adductor tendinopathy as a source of ongoing chronic postoperative inguinal pain—evaluating outcomes of adductor tenotomy

To evaluate the outcome of an adductor muscle tenotomy in patients with chronic postoperative inguinal pain (CPIP) with a therapy-resistant adductor tendinopathy. In this retrospective cohort study, CPIP patients who underwent an adductor tenotomy between January 2019 and Decembe...

Cross-national clinical exchange in child psychiatry across cultural contexts and mental health systems: a scoping review

Abstract Background Clinical practice in child and adolescent psychiatry (CAP) relies on internationally shared, empirically grounded guidelines, yet their application is influenced by socioeconomic and cultural differences. Cross-national clinical exchange allows health professi...

A Systematic Review (and Meta-Analysis) and Global Expert Consensus Statements (U-POP): The Manchester Procedure

Abstract Introduction and Hypothesis The Manchester procedure (MP) is the oldest uterus-sparing technique for uterine prolapse and has traditionally been used to treat cervical elongation (CE). However, its optimal application remains unclear. This review aimed to evaluate the be...

Reliability, validity, and change over time in disinhibited and disruptive behaviors assessed with the age‐adapted disruptive behavior diagnostic observation schedule in children aged 5–12 years with ADHD

Abstract Background Previous research has shown that the disruptive behavior diagnostic observation schedule (DB‐DOS) is a valid and reliable clinic‐based assessment of disinhibited and disruptive behaviors in preschoolers. We adapted the DB‐DOS for use in children aged 5–12 year...

Obesity, incretin-based therapies, and cardiovascular disease in women

Abstract Obesity in women is a growing and multifaceted public health challenge, driven by complex interactions among biological, hormonal, and psychosocial factors across the life course. From menarche to menopause, hormonal fluctuations influence fat distribution, energy balanc...

Beyond weight loss: the value of physical activity and exercise for improving cardiometabolic risk factors in individuals with overweight and obesity

Abstract The global prevalence of overweight and obesity has increased markedly over recent decades. In clinical obesity care, and in the management of other chronic conditions, the role of physical exercise has largely been evaluated in the context of weight loss. Yet, while it...