Radboud University Nijmegen

DUTCH weight control in atrial fibrillation study (DUTCH-WAIST)

Abstract Background Obesity is a well-established and highly prevalent risk factor for atrial fibrillation (AF) and its progression by promoting structural and electrical atrial remodelling, leading to AF recurrence and persistence. Weight loss is expected to reverse atrial remod...

Beyond weight loss: the value of physical activity and exercise for improving cardiometabolic risk factors in individuals with overweight and obesity

Abstract The global prevalence of overweight and obesity has increased markedly over recent decades. In clinical obesity care, and in the management of other chronic conditions, the role of physical exercise has largely been evaluated in the context of weight loss. Yet, while it...

Bone morphology influences asymptomatic knee kinematics across the flexion range: a dynamic CT study

Considerable inter-individual variability in knee kinematics exists even within asymptomatic populations, yet the extent to which this variability relates to underlying morphology remains poorly understood. This study aimed to identify morphological features associated with asymp...

Radium-223 decreases PD-L1 expression in bone metastases: A study with [89Zr]Zr-atezolizumab PET and immunohistological correlation

Abstract Purpose Most patients with metastatic castration-resistant prostate cancer (mCRPC) do not benefit from treatment with immune checkpoint inhibitors targeting programmed cell death (ligand) 1 (PD-(L)1). Radiation might improve response to immunotherapy by increasing the im...

The Infant and Toddler Curiosity Questionnaire: Dutch Translation and Validation

Curiosity and its role in learning and early cognitive development has received increasing attention in infancy research. So far, insights have largely focused on controlled lab-based experimental studies while less is known about individual differences in infants’ curiosity in e...

Biomarkers through time: from bench to big data (@EATRIS-CONNECT summer school 2026)

Opening keynote lecture for a audience of young translational medicine scientists as part of the EATRIS-CONNECT summer school. EATRIS-CONNECT is the flagshp project of EATRIS (European scientific infrastructure for translational medicine, see eatris.eu) that aims at mapping and i...

Outcomes of Asian and Caucasian patients with type A aortic intramural haematoma: a multicentre registry analysis

Background Outcomes of aortic intramural haematoma (IMH) have shown disparities between Asian and Caucasian patients. We evaluated the heterogeneity of treatment effects in Asian and Caucasian patients with type A IMH. Methods This multicentre registry included individual patient...

Non‐contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor‐Associated Intracerebral Hemorrhage: An Analysis from ANNEXa ‐I Trial

In this post hoc analysis of the ANNEXa-I trial (n = 434), we evaluated non-contrast computed tomography (NCCT) markers of hematoma expansion (HE) in factor Xa inhibitor (FXai) -associated intracerebral hemorrhage (ICH). At least one NCCT marker was present in 72.1%, and HE (≥12....

Supporting clinical guidelines for opioid conversion to methadone and tapering to prevent withdrawal in critically ill children using physiology based pharmacokinetic modeling and simulation

Long-term opioid use is common in critically ill children and can cause withdrawal symptoms at discontinuation. To avoid withdrawal, short-acting opioids are usually converted into a long-acting drug, such as methadone, which is then carefully tapered. However, the exact conversi...

Biodiesel soot incandescence and NO emission studied in an optical engine

High-speed imaging and thermodynamical characterization are applied to an optically accessible, heavy-duty diesel engine in order to compare soot incandescence and NO emission behaviour of four bioderived fuels: rapeseed-methylester, Jatropha oil (pure), Jatropha-methylester and...

Influence of Ageing on the Pharmacology, Efficacy and Safety of Oral Targeted Therapies for Inflammatory Bowel Disease: Focus on Janus Kinase (JAK) Inhibitors and Sphingosine-1-Phosphate (S1P) Receptor Modulators

Older adults represent a rapidly expanding subgroup of patients with inflammatory bowel disease, yet they remain markedly under-represented in pivotal clinical trials, limiting age-specific estimates of drug benefit and harm. This review synthesises the available evidence on the...

Cross-modal processing of auditory and visual symbol representations in the temporo-parietal cortex

Numeracy and literacy are fundamental cognitive skills that rely on associating visual symbols with their spoken representations. Prior research has identified the posterior temporal-parietal cortex as a key neural region for the cross-modal transformation of these audio-visual a...

Personalization in professional academic search

In this paper, we investigated how academic search can profit from personalization by incorporating query history and background knowledge in the ranking of the results. We implemented both techniques in a language modelling framework, using the Indri search engine. For our exper...

Low-Dose Naltrexone in Crohn’s Disease: A Prematurely Terminated Randomized Trial Showing Reduced Fatigue Without Clinical or Endoscopic Benefit

Crohn’s disease (CD) is often refractory to standard therapies, and patients are sometimes reluctant to initiate immunosuppressive therapy, prompting interest in novel treatments such as low-dose naltrexone (LDN). To evaluate the efficacy of LDN for induction of remission in pati...

Environmental and host-associated factors are the main determining factors for the salmonid gill microbiome

Gill health is a major issue in aquaculture and the role of the gill microbiome in salmonid gill health is a growing research topic. To establish the role of gill microbiota in salmonid health, it is essential to understand the importance of environmental factors and fish-associa...

Multilingual large language models do not comprehend all natural languages to equal degrees

Abstract Large Language Models (LLMs) play a critical role in how humans access information. While their core functionality relies on the ability to comprehend written requests, our understanding of this ability is currently constrained, because most benchmarks evaluate LLMs in h...

Video-based quantification of leg agility in Parkinson’s disease and its relationship to upper extremity motor impairments

Abstract Bradykinesia is a hallmark sign of Parkinson’s disease (PD). Current clinical assessment is susceptible to inter-rater variability and only provides a single, ordinal severity score. Here, we propose a computer vision-based framework to quantify distinct motor characteri...

The Key Factor Toxicity: development and application of a toxic pressure characterization tool for surface and drinking water

The European Water Framework Directive (WFD) aims to ensure a status with sufficient good-quality water to sustain ecosystems and drinking water production. Water quality is, however, affected by complex mixtures of polluting substances, whose combined effects are poorly captured...

Global variability in cardiovascular care of pediatric cancer patients and survivors: survey results from the International Cardio Oncology Society (ICOS)

Childhood cancer survivors (CCS) are at elevated risk for cardiovascular disease due to cardiotoxic cancer therapies. Different international guidelines and recommendations for follow-up were published. However, global practices surrounding cardiovascular risk assessment, screeni...

Multiscale physical effects of CpG methylation on DNA mechanics, nucleosome wrapping, and chromatin condensates

DNA methylation at CpG dinucleotides is a central epigenetic modification linked to transcriptional repression and heterochromatin formation, yet its physical impact on chromatin organization remains incompletely understood. Here, we integrate single-molecule force spectroscopy,...