Radboud University Nijmegen

Model 1b analytical performance specifications – report on the Prague 2025 workshop

diagnostic medical devices (IVD MD) meet regulatory and quality standards before market release; for external quality assurance assessments; for quality control, monitoring reagent lot-to-lot variability, and allowing preanalytical variation assessments in labs; and for guiding p...

Chatbots reduce health-related conspiracy beliefs not because of but despite being perceived as AI

<title>Abstract</title> Beliefs in conspiracy theories and their resistance to correction pose critical challenges to public health. A potential countermeasure to this is the use of Large Language Model (LLM) driven debates about conspiracy theories. Yet while this approach yield...

Tiny Droplets, Large Insights: Studying Peptide Aggregationwith Droplet-Based Microfluidics Hyphenated with Ion Mobility MassSpectrometry

Abstract Peptide and protein aggregation are hallmarks of numerous neurodegenerative diseases. However, the structural characterization of oligomeric intermediates remains challenging due to their low abundance, heterogenic nature, and complexity of coinciding and transient react...

Fatal invasive pulmonary aspergillosis caused by Aspergillus texensis: first documented human infection

<title>Abstract</title> Background Invasive Aspergillosis (IA) is a life-threatening infection in immunocompromised patients. Although <italic>Aspergillus fumigatus</italic> predominates, rare and cryptic species are increasingly recognized due to advances in molecular diagnostic...

A Comprehensive Methodology for Estimating Yearly Plastic Pollution Loads in Rivers

Abstract Plastic pollution in freshwater systems represents a major global concern, as rivers serve as critical pathways between land-based sources and marine environments. Yet, inconsistencies are observed between estimated plastic inputs from land and concentrations in the ocea...

Using the Stressor-System-Resilience Resources-Outcomes (SSRO) scaffold to clarify the core components of resilience research in medicine

Abstract Modern medicine increasingly extends beyond treating disease to supporting individuals through recovery, adaptation, and long-term functioning, all central to the concept of resilience. Despite growing interest, resilience remains conceptually difficult to structure and...

GRB 260310A / SN 2026fgk: A Multi-Wavelength Study of a Nearby Underluminous Long GRB and SN with a Complex Afterglow

Abstract We present a comprehensive multi-wavelength study of GRB 260310A / SN 2026fgk, a nearby (z = 0.153), long-duration gamma-ray burst (GRB) with an exceptionally underluminous prompt γ-ray emission and a Comptonized spectrum. The burst occurred at the edge of a blue host ga...

Acceptability and Feasibility of Mindfulness-Based Cognitive Therapy in Adults with Inflammatory Bowel Disease: A Mixed-Methods Study

Abstract Objectives The high psychological burden of inflammatory bowel diseases (IBD) underscores the need for effective and feasible psychological treatment options. This study aimed to explore the acceptability and feasibility of mindfulness-based cognitive therapy (MBCT) for...

Biosynthesis and Genetic Tuning of Guanine Crystals via Metabolic Engineering of Yeast

ABSTRACT Purine crystals, such as guanine, generate diverse optical phenomena in animals and function as important nitrogen‐storage reservoirs in microalgae. Here, we demonstrate the formation of guanine crystals in Brewer's yeast. Whilst guanine crystals do not naturally contrib...

Performance Estimation and Ex Vivo Validation of Untethered Magnetic Robots in Soft Tissue

ABSTRACT The navigation and control of untethered magnetic robots (UMRs) within soft brain tissue critically depend on their ability to maintain synchronized rotation under applied rotational magnetic fields. The fundamental upper limit of this magnetic synchronization, known as...

The Dutch Prolactinoma Cohort Studies: Cross-sectional Analysis of Females Focusing on the Patient's Perspective

Abstract Purpose To assess the results of patient-reported outcome measures (PROMs) in a national cohort of females with a prolactinoma by disease activity. Methods Females with prolactinoma included in the PRolaCT or ProlaC study were assessed cross-sectionally, comparing patien...

Photo‐Activated Merging Cascades in Droplet Swarms Upon Synergistic Solvation of Surfactants

ABSTRACT Chemically active droplets at fluid interfaces provide versatile building blocks for dynamic matter, yet most systems are limited to behavior encoded within individual droplets or simple pairwise interactions. Here, we report a strategy to generate non‐linear, cascading...

LncPNdeep: A long non-coding RNA classifier based on large language model with peptide and nucleotide embedding

Abstract Long non-coding RNA plays an important role in various gene transcription and peptide interactions. Classifying lncRNAs from coding RNA is a crucial step in bioinformatics analysis which seriously affects the post-analysis for transcriptome annotation. Although several m...

Resilience and adaptation of cancer screening programs to external crises

Objectives To examine how cancer screening programs resumed during the COVID-19 pandemic, focusing on their resilience in terms of coordination, communication, recovery, participation rates, catch-up efforts, inequities, and preparedness. Setting Cancer screening programs represe...

Prevalence and Correlates of Non-Prescribed Methylphenidate Use: A Cross-Sectional Study in Dutch University Students

Background Methylphenidate, prescribed for ADHD, is also used without prescription by students to enhance cognitive performance. While correlates of non-prescribed methylphenidate (NPM) use have been identified, few studies compared recent and former use across domains. This stud...

Soft-tissue thickness changes following bimaxillary surgery in skeletal class II malocclusion

OBJECTIVES: This retrospective cohort study evaluated regional facial soft-tissue thickness changes after bimaxillary surgery in skeletal Class Ⅱ patients and assessed their associations with skeletal movement and patient-related factors. MATERIALS AND METHODS: Class Ⅱ patients t...

Psychological interventions to improve maternal mental health and resilience during pregnancy in the COVID-19 pandemic: a systematic review

BACKGROUND: During the COVID-19 pandemic, pregnant women experienced increased psychological distress, while access to routine mental health care was often disrupted. Psychological interventions may provide an effective strategy to support maternal mental health under these circu...

Human ticklishness is a widespread, culturally shared and bodily organized sensory experience

Abstract Human ticklishness is one of the oldest yet unresolved scientific puzzles. As early as the time of Aristotle and Socrates, scholars have speculated on its origins and function, but fundamental questions remain. Is ticklishness culturally shared or specific? Does it follo...

The Dutch cardiomyopathy registry (DCR); rationale and registry design

BACKGROUND: Cardiomyopathies are important causes of arrhythmias, sudden cardiac death, and heart failure. With accumulating knowledge in clinical, genetic, and molecular phenotyping, the number of distinct disease entities is growing. There is a need for broad, inclusive, high-q...

Soil inoculation enhances early‐phase reintroduction success in two rare plant species

Abstract Introduction Reintroduction for conservation is an important measure to restore populations of vulnerable plant species. However, reintroduction success rates are relatively low. Inoculating reintroduced plants with facilitative microorganisms from native populations may...