Princeton University

“Store-and-Release” Strategy Enables Nickel-Catalyzed Deaminative Migratory Arylation of Aliphatic Amines

Abstract While migratory functionalization reactions provide a powerful means to navigate broader chemical space, their application to aliphatic amines remains particularly elusive. Herein, we describe the nickel-catalyzed migratory arylation of aliphatic amines using Katritzky s...

The value of a prophage-borne defense system in phage–phage competition

Temperate phages that incorporate into their bacterial hosts’ genomes often encode defense systems that protect their hosts from superinfection by unrelated phages. Yet the evolutionary value of such defenses to the phage remains unclear. We present a minimal theoretical framewor...

Optimizing multi-gene co-expression with large plasmids

Large plasmids are often avoided in mammalian co-transfection due to the assumption that they transfect poorly, driving the use of multiple smaller plasmids. Here, we pair finite-state-projection modeling with flow cytometry experiments to compare one-, two-, and three-plasmid de...

Generation and Reactivity of the Antiaromatic 3,6-Dibromocarbazolyl Nitrenium Ion

Abstract The reactivity of the 3,6-dibromocarbazolyl nitrenium ion was investigated to determine how antiaromatic destabilization influences nitrenium ion chemistry. Laser flash photolysis and kinetic isotope effect experiments were employed to investigate the reactivity of this...

An Interval-Certified Positivity Block at c=13 for an Odd Pole-Free Riemann Reduction

We establish positivity of the canonical localized pole-free odd closed form at the fixed support parameter c=13. The proof combines an exact arithmetic-source identification, a uniform high-diagonal Schur transfer, finite interval-certified elimination, and a corrected enclosure...

First-Principles Microkinetic Model for Ammonia Synthesis on Fe(110) under Nonequilibrium Programmable Heating and Quenching Operation

Abstract Traditional thermochemical processes typically operate under relatively static conditions, where conventional reactors restrict the time scales over which key reaction parameters (such as temperature) can be varied. Electrification via Joule heating offers a way to overc...

Cross-platformization: How U.S. right-leaning media curate their posts on Twitter and Truth Social

This study examines how seven right-leaning media organizations utilize cross-platformization strategies to reach audiences across multiple platforms; in this case, Twitter and Truth Social. Focusing on both content volume and story packaging, we collect right-leaning media organ...

Regime-Aware Reinforcement Learning: A Mixture-of-Experts Framework for Dynamic Asset Allocation

Recent advances in reinforcement learning (RL) have spurred growing interest in its application to multi-period financial planning. Existing literature broadly follows three paradigms: hybrid RL, scalable RL, and end-to-end RL. This paper develops a hybrid regime-aware RL framewo...

A Rigorous Finite-Dimensional Verifier for an Odd Pole-Free Riemann Positivity Criterion

We develop a rigorous numerical verification framework for a finite-dimensional positivity problem arising from an odd, pole-free formulation connected to the Riemann hypothesis. The computational objective is not to infer positivity from floating-point evidence, but to certify e...

Quantum Light Spectroscopy

Abstract Spectroscopy based on individual-photon-level light sources brings new variables to both spectroscopy and imaging. We refer to this approach as quantum-light spectroscopy (QLS). The photon statistics of different types of photon sources and photon entanglements are brief...

High-capacity associative memory in a quantum-optical spin glass

The Hopfield neural network stores memories using all-to-all-coupled spins and recalls those memories through equilibrium dynamics. Storing too many hampers recall because frustration causes an exponential number of spurious patterns to arise as the network becomes a spin glass....

Developmental scarcity induces sex differences in social recognition and CA2 perineuronal nets

Abstract Early-life adversity has a lasting negative impact on social behavior in both humans and rodents. Sex differences exist in functional outcomes of postnatal stress, but underlying mechanisms remain incompletely explored. Using the limited bedding and nesting paradigm, a m...

Continuum canonical purifications

A bstract We construct and characterize canonical purifications for general algebraic states, extending prior constructions by Woronowicz and by Dutta/Faulkner to general quantum field theories. Given a quantum state on a *-algebra, the canonical purification is a state on a “dou...

Real-time nuclear–electronic orbital time-dependent density functional theory with a constrained traveling proton basis

Nuclear quantum effects and non-Born-Oppenheimer effects play a vital role in many chemical and biological processes, motivating the incorporation of such effects into dynamical simulations. In real-time nuclear-electronic orbital time-dependent density functional theory (RT-NEO-...

Perinatal Depression and Infant Mortality

Importance Perinatal depression is the most common maternal morbidity, but few US studies have examined whether perinatal depression is associated with infant mortality. Objectives To examine the association between maternal depressive symptoms and infant mortality, assess hetero...

The geography of immigrants in same-sex couples in the United States

The policy landscape for same-sex couples in the United States has changed rapidly in recent years, and the number of immigrants in same-sex couples has markedly increased. Little is known, however, about where these lesbian, gay, bisexual, and queer (LGBQ) immigrants settle and...

Bringing Reinforcement Learning to Multi-Period Financial Planning: A Bridge Between Learning-Enabled and Stochastic Optimization

Abstract Financial planning is rarely a one-shot decision: today’s saving, spending, and investment choices shape tomorrow’s wealth, liabilities, and goal attainment. This survey traces the mathematical evolution of multi-period financial planning over the past several decades, f...

New Electron Population Trapped at Low Latitudes Near Jupiter

Abstract We report observations of a low energy (<2 keV), trapped electron population near Jupiter's magnetic equator made by the Jovian Auroral Distributions Experiment (JADE) on Juno. Electron intensity peaks around the location of the minimum magnetic field magnitude along the...

Obesity Is Associated With Earlier Mechanical Failure Following Total Ankle Arthroplasty Independent of Tibial Stem or Keel Augmentation

Background: Obesity and elevated body mass have been associated with increased rates of aseptic loosening and implant failure following total ankle arthroplasty (TAA). The purpose of this study was to investigate the role for primary stemmed or keeled tibial implants as a protect...

Wind‐Driven Circulation Feedbacks Offset Tropical Geoengineered Sea Salt Emissions

Abstract Using a NOAA Geophysical Fluid Dynamics Laboratory coupled atmosphere–ocean (CM4) comprehensive model, we employ simulations of enhanced, geoengineered sea salt aerosol (SSA) emissions in the tropics to examine the circulation response to idealized marine cloud brighteni...