Princeton University

Second quantization of the nonlinear Vlasov–Poisson system for quantum computation

Abstract Current quantum algorithms for plasma physics require linearized systems, and quantum algorithms for nonlinear systems are highly system-specific. Second quantization, which is system-agnostic, has the exceptional capacity to render many systems suitable for quantum comp...

Understanding Goal Selection Through Human Limitations

Abstract From climbing mountains to playing video games, people have a striking ability to make a goal out of just about anything. However, people do not choose their goals haphazardly. Instead, they often rely on previously chosen goals to inform the ones they choose in the futu...

Safeguarding global terrestrial vertebrate species from future sea-level rise

Sea-level rise (SLR) threatens terrestrial biodiversity, yet its spatiotemporal and species-specific impacts remain unclear. Integrating relative SLR projections across five Shared Socioeconomic Pathways (SSPs) with Area of Habitat (AOH) maps for 34,120 terrestrial vertebrate spe...

Dual‐Comb Spectroscopy With Fully Controlled Repetition Rate and Offset Frequency of Quantum Cascade Laser Frequency Combs

ABSTRACT Quantum cascade laser frequency combs (QCL‐FCs) are promising light sources for sensing applications, thanks to their convenient electrical pumping, chip‐scale footprint, high optical power, and relatively broadband emission in the mid‐infrared molecular fingerprint spec...

Lysosomal Expansion Compartments Mediate Zinc and Copper Homeostasis in Caenorhabditis elegans

Abstract Zinc is an essential transition metal that participates in many biological processes. In C. elegans, excess zinc is stored in lysosomes in intestinal cells; this process involves increasing the expression of the zinc transporter CDF-2 and remodeling of lysosomes characte...

Challenges for the effectiveness of infectious disease interventions during global change

Global change, including climate change, land-use change, and increased human mobility, is expected to have complex effects on the transmission, evolution, and emergence of infectious diseases 1 , 2 . Current research agendas aim to understand how these environmental and anthropo...

Tribal nations’ flood exposure and the U.S. national flood insurance program

Tribal nations experience significant flood impacts, yet participation in the National Flood Insurance Program remains limited. We analyze flood events, claims, and 57 Tribal Hazard Mitigation Plans, and insights from a tribal representative, to identify disparities in insured re...

Statistical methods for partitioning ribbon and globally-distributed flux using data from the Interstellar Boundary Explorer

NASA’s Interstellar Boundary Explorer (IBEX) satellite collects data on energetic neutral atoms (ENAs) that can provide insight into the heliosphere boundary between our solar system and interstellar space. Using these data, scientists can construct maps of the ENA intensities (o...

Nuclear–Electronic Orbital Coupled Cluster Theory with the Nuclear Hartree Product Representation for Multiple Quantum Nuclei and Application to Geometric Isotope Effects

Abstract Nuclear–electronic orbital (NEO) methods treat specified nuclei, typically protons, quantum mechanically on the same level as electrons within quantum chemical calculations. This approach allows the computationally efficient inclusion of nuclear quantum effects such as n...

THE MYTH OF ‘ABANDONMENT’: FINDING (SEMI-)NOMADIC INHABITATIONS OF ANATOLIAN ANTIQUITIES AMIDST THE LIMITATIONS OF LONG-NINETEENTH-CENTURY TRAVELOGUES

Descriptions of abandoned ruins abound across the pages of travelogues created by European visitors to Ottoman Anatolia during the long nineteenth century. Yet, remnants of ancient architecture were often less devoid of inhabitation than these authors presented. Some of the most...

Not all debt is equal: Debt type, burden, and life satisfaction among urban young adults in Seoul

Young adults in rapidly growing cities face mounting financial pressures from escalating housing costs and limited access to stable employment. This study examines how different debt types and perceived debt burden are associated with life satisfaction among young adults in Seoul...

Steric‐Setup Effects on US East Coast Sea‐Level Change

Abstract The extent to which coastal sea levels co‐vary with open‐ocean variability is explored through evaluation of a balanced dynamics framework relating sea level with pressure, density, and velocity along the continental shelf and slope seafloor. Using high‐resolution region...

Alzheimer’s disease neuropathological characterization of the dog brain and relationship to biofluid biomarkers and cognitive function

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting more than 55 million people worldwide and is characterized by cognitive decline, amyloid-beta (Aβ) plaques, and neurofibrillary tangles. Although transgenic rodent models have advanced understanding of...

Polymer-residue accessibility shapes sequence dependence of critical temperatures for phase separation

Biological polymers, such as intrinsically disordered proteins, play a central role in cellular biology, including mediating phase separation and controlling activity of biological condensates. The physical properties and functions of biopolymers are determined by their residue s...

Nuclear–Electronic Orbital Theory: Exploring Nuclear Quantum Effects in Chemistry, Biology, and Materials

Abstract Nuclear quantum effects play a critical role throughout chemistry, biology, and materials science. This Perspective presents the nuclear–electronic orbital (NEO) framework as a viable approach for incorporating nuclear quantum effects into calculations of relatively larg...

A Multi-Institutional Digital Twin and AI Educational Platform for Advanced Microelectronics Fabrication and Device Packaging Training

Technology today is at a crossroad between Industry 4.0 and 5.0, where products and services are manufactured and designed to be ‘human-centered’ and sustainable. Such objectives have always been expected in education, especially in the way the workforce is trained. Leveraging on...

Scalable, Simple, and Versatile Encapsulation of 2D Materials and Devices

Abstract Air-sensitive 2D materials present fundamental challenges for device integration. Encapsulation is required to preserve intrinsic properties, yet conventional strategies require complicated fabrication workflows and fail with thicker flakes. We demonstrate that electron-...

Breast cancer stem cell metabolism: metabolic plasticity and microenvironmental regulation

Breast cancer stem cells (BCSCs) are a tumorigenic cell population implicated in tumor initiation, therapeutic resistance, metastasis, and disease recurrence. Increasing evidence indicates that metabolic reprogramming is a fundamental feature of BCSC biology, enabling these cells...

Comparative Analyses of the Type D ASEP: Stochastic Fusion and Crystal Bases

The Type D asymmetric simple exclusion process (ASEP), a particle system involving two classes of particles, was studied from both probabilistic and algebraic perspectives by Kuan et al. (2022). From a probabilistic perspective, we perform stochastic fusion on the Type D ASEP int...

Widespread Biosynthesis of Thiohistidine Dipeptides in Bacteria

Abstract Natural products have been paramount in inspiring novel chemistry as well as providing therapeutic agents and chemical tools for biological applications. A recently emerging class of natural products, the thio/seleno-imidazoles (TSIs), contains C–S or C–Se bonds that are...