Princeton University

Cognitive reappraisal changes cognitive evaluations of images more strongly than affective reactions

Abstract Cognitive reappraisal is an emotion regulation strategy that involves changing one’s interpretation of a situation to change its emotional impact. Cognitive reappraisal studies typically assess changes in valence ratings following reappraisal as the primary dependent var...

Bridging the social license gap: How community-directed communication shapes risk perception and acceptance of carbon capture and storage in the United States

Achieving global climate targets demands rapid deployment of new technologies, yet technological readiness risks outpacing the social license needed for deployment. Carbon capture and storage (CCS) exemplifies this challenge: deployment is expanding rapidly, but public awareness...

Evaluating Mechanical-EmbeddingML/MM for PredictingMutation Effects in Chorismate Mutase Catalysis

Abstract Predicting how mutations alter enzyme catalysis remains a central challenge in enzymology and enzyme engineering. Although quantum mechanics/molecular mechanics (QM/MM) simulations can in principle compute the activation free energy associated with enzymatic reactions, t...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...

Linker Symmetry Lowering as a Strategy to Tune Electronic Properties in Two‐Dimensional Conductive MOFs

ABSTRACT Two‐dimensional conductive metal–organic frameworks (2D cMOFs) have largely relied on highly symmetric linkers that give rise to symmetry‐protected electronic degeneracies. Although such symmetry usually promotes extended conjugation and often leads to high electrical co...

Dynamics, function, and regulation of mammary stem cells in development and disease

Understanding the heterogeneity of mammary epithelial cells and their contributions to postnatal development and regeneration is of great importance. Recent advances have defined the intrinsic complexity of the mammary epithelium, its stromal interactions, and the ontogeny of adu...

What Does It Mean to Be Black? Experimental Evidence on the Situational Deployment of Racial Schemas

How do Black Americans construct narratives about the meaning and boundaries of Blackness in America today? We leverage an original, nationally representative survey experiment among U.S.-born Black Americans ( n = 3,100) to examine (1) justifications used to validate or reject a...

Structural insights into xyloglucan recognition by an ABC transporter from a Gram‐positive, thermophilic bacterium

Xyloglucan (an α‐1,6‐xylosyl–substituted β‐1,4‐glucan) is a major hemicellulose of the primary cell wall of many plants and an important growth substrate for biomass‐degrading bacteria in diverse ecological niches, including the gut microbiome and hot springs. In Gram‐positive ba...