Peking University

Cross-Scale Mixed Conduction in Organic Electrochemical Transistors: From Nanoscale Ion–Electron Coupling to Biointegrated Intelligence

Abstract Organic electrochemical transistors (OECTs) are emerging at the convergence of nanoscience, soft materials, and bioelectronics because they couple the ionic signals of living systems with amplified electronic readout through hydrated organic mixed ionic–electronic conduc...

A Sequence-to-Scaffold Platform Enables Programmable Carrier-Supported Biocatalysis for Nucleoside Analog Synthesis

Abstract Industrial biocatalysis increasingly requires strategies that convert enzyme discovery into robust catalyst systems for process implementation. Here, we report Spatially Programmable Assembly of Computationally Mined Enzymes (SPACE), a sequence-to-scaffold workflow coupl...

Geometric morphological parameters from cardiac magnetic resonance imaging in assessment of chronic pulmonary thromboembolism, a prospective pilot study

Abstract Objective The role of geometric-morphological parameters derived from cardiac magnetic resonance imaging (CMR) in assessing and stratifying chronic pulmonary thromboembolism (CPTE) remains unclear. Material and methods We prospectively enrolled 53 CPTE patients (16 with...

Exploring Priority Intrapartum Services Associated with Childbirth Experience During Vaginal Birth: A Multicenter Cross-Sectional Study

Background: A woman’s childbirth experience is important to her health and family well-being. Evidence-based intrapartum care may support a positive experience. When resources are constrained, identifying services that are most strongly associated with childbirth experience may h...

Association of the C-reactive protein-triglyceride glucose index with incident hypertension across glycemic status: a longitudinal cohort study

The C-reactive protein-triglyceride glucose index (CTI) is a composite indicator that integrates systemic inflammation, lipid metabolism, and glucose metabolism. Previous studies have reported an association between CTI and incident hypertension, but evidence across different gly...

Visual snow syndrome as a neuropsychiatric network disorder: clinical features, mechanisms, and therapeutic perspectives

Abstract Visual Snow Syndrome (VSS) is a neurological condition characterized by the persistent perception of dynamic, flickering, dot-like visual disturbances across the entire visual field, resembling television static. Increasing evidence indicates that VSS is frequently accom...

A Self-Marangoni-Propelled Droplet Microarray for Ultrafast Mixing and Point-of-Care Assay of Acute Myocardial Infarction Biomarkers

Abstract Droplet microarrays hold great promise for acute myocardial infarction (AMI) diagnosis, yet their biosensing performance is often limited by poor mixing efficiency and nonuniform signal distribution. Here, we report a self-Marangoni-propelled droplet microarray featuring...

School-based hygiene intervention to prevent Helicobacter Pylori infection among children (SHIP HOPE): a cluster-randomized controlled trial

Helicobacter pylori ( H. pylori ) is a major cause of gastric cancer and is typically acquired during childhood. Preventing infection in uninfected children is a promising strategy; however, the effectiveness of hygiene-based interventions remains uncertain. This study aimed to d...

Composite Crystalline Aluminum Nitride Passivation for Near-Junction Thermal Management in Gallium Nitride High-Electron-Mobility Transistors

In this work, we demonstrate a composite crystalline aluminum nitride (AlN) passivation layer for near-junction thermal management in aluminum gallium nitride/gallium nitride (AlGaN/GaN) high-electron-mobility transistors (HEMTs). The 120-nm-thick AlN film consists of an ordered...

Clinical and radiographic outcomes of second molars with external root resorption following impacted third molar removal: a retrospective CBCT-based cohort study

To evaluate the clinical and radiographic outcomes of second molars (M2s) affected by external root resorption (ERR) following impacted third molar (M3) removal, and to assess the influence of adjunctive guided bone regeneration (GBR). This retrospective cohort study included pat...

Experiential avoidance as an early mechanism of an online mindfulness-based intervention for emotional distress: evidence from a behavioral paradigm in a randomized controlled trial

Given the substantial burden of global emotional distress and the proven efficacy of mindfulness-based interventions (MBIs), identifying early mechanisms of MBIs is critical for optimizing treatment adherence and outcomes. This study employed behavioral measures to investigate ex...

Active commuting and biological aging: Cross-sectional evidence from the UK Biobank

Objective To investigate whether commuting mode is associated with biological aging, including KDM 's Biological Age Acceleration (KDM-BAA), PhenoAge Acceleration (PhenoAA) and leukocyte telomere length (LTL) based on the UK Biobank (UKB). Methods We performed a cross-sectional s...

Rimegepant for vestibular and cochlear symptoms associated with vertigo in a real-world retrospective study

Vertigo commonly co-occurs with cochlear symptoms, yet evidence for calcitonin gene-related peptide (CGRP) receptor antagonists across audiovestibular disorders remains limited. We retrospectively evaluated 54 adults with vertigo who received rimegepant 75 mg daily or every other...

Current and future burden of gastric cancer: an analysis based on CDC WONDER and the global cancer observatory

Gastric cancer remains a major contributor to the global cancer burden, with marked geographic disparities and a substantial contribution from population ageing. We aimed to integrate recent mortality trends in the United States with the latest global burden estimates to provide...

Interplay of Lattice Distortion and Cation Disorder Governs Li-Ion Transport in Cation-Disordered Rocksalt Cathodes

Abstract Cation-disordered solids provide a chemically complex landscape in which local environments, lattice responses, and configurational disorder collectively influence ion transport. In cation-disordered rocksalt cathodes, Li+ diffusion has traditionally been interpreted usi...

Sex-specific effects of early-life arsenic exposure on body weight, arsenic metabolism, and gut microbiome stability in C57BL/6J mice

Arsenic exposure in early-life is strongly linked to health risks for mothers and their offspring. Although the mechanisms by which arsenic induces the toxicity and health impacts remain unclear, the gut microbiome makes key contributions to the metabolism of arsenic. This study...

NBS ‐Mediated Mitsunobu Glycosylation: Facile Assembly of N ‐Glycosides from Unprotected Sugars and Application to Polysaccharide Analysis

Comprehensive Summary Chemical N ‐glycosylation is a crucial step in the synthesis of complex N ‐glycosides, particularly nucleosides. However, traditional carbohydrate chemistry often relies heavily on protecting groups, which can lead to cumbersome, time‐consuming substrate pre...

Environmental regulation, synergistic emission reduction, and regional environmental spillover effects: A quasi-natural experiment from rare earth industry emission standards

Rare earth elements are critical materials, yet their production imposes severe ecological damage and pollution. This paper investigates the synergistic emission reduction effects, underlying mechanisms, and regional environmental spillovers of pollutant emission standards in Chi...

Universal synthesis of high-entropy alloy nanostructures with femtosecond lasers

High-entropy alloy nanostructures (HEA-NSs) hold promise in advanced catalysis and materials science, but lack a robust and universal synthetic strategy designed at an atomic level. Here, femtosecond lasers are used to prepare HEA-NSs, from single atoms to 100 nm nanoparticles, e...

Onvansertib-mediated PLK1 inhibition impairs spermatogenesis in the murine testis

Onvansertib (ONV) is a selective inhibitor of polo-like kinase 1 (PLK1) and has promise in treating cancer. However, its potential effects on male reproductive function remain insufficiently characterized. In this study, male mice received clinically relevant doses of ONV by intr...