Peking University

Cotangent cohomology and quadratic obstructions of matroids

Let M be a finite matroid and let T²(M) denote the second cotangent cohomology of its Stanley–Reisner ring over an arbitrary field. We compute every multigraded component of T²(M) from the connected components of explicit graphs on flats in dual links. This gives the fine Hilbert...

Nodal-Length Bounds for Surface Metrics with Isolated Non-Analytic Points

We prove a C_g sqrt(lambda) upper bound for nodal lengths on closed surfaces whose metrics are analytic away from finitely many isolated points and satisfy a summable quantitative analytic-scale condition near those points. The result includes an explicit smooth non-analytic toru...

Caspase-11-mediated non-canonical pyroptosis is a key mechanism of alveolar epithelial cell injury in LPS-induced ARDS

Alveolar epithelial cells (AECs) injury is a critical event in the pathogenesis of acute respiratory distress syndrome (ARDS); however, the underlying mechanisms remain complex, and it is still unclear which cell death or inflammatory pathway predominates. In this study, we analy...

From OSS to Open Source AI: an Exploratory Study of Collaborative Development Paradigm Divergence

AI development is embracing open-source paradigm, but the fundamental distinction between AI models and traditional software artifacts may lead to a divergent open-source development paradigm with different collaborative practices, which remains unexplored. We therefore bridge th...

Screw you, warrior wolves!: the ambivalent politics of satirizing militarized masculinity in neo/non-liberal China

Satire can function both as a form of resistance that unsettles existing gender orders and as a mechanism through which such orders are reproduced. This study situates the satirical engagement with Wolf Warrior-style militarized masculinity within the context of neo/non-liberal C...

Nodal-Length Bounds for Surface Metrics with Isolated Non-Analytic Points

We prove a C_g sqrt(lambda) upper bound for nodal lengths on closed surfaces whose metrics are analytic away from finitely many isolated points and satisfy a summable quantitative analytic-scale condition near those points. The result includes an explicit smooth non-analytic toru...

In Vitro Activity of Imipenem/Relebactam and Ceftolozane/Tazobactam Against Multidrug-Resistant Klebsiella pneumoniae: A Retrospective Single-Center Study in China

Background: Multidrug-resistant Klebsiella pneumoniae (MDR-KP) is a global health threat with limited treatment options. Comparative in vitro data for imipenem-relebactam (I/R) and ceftolozane-tazobactam (C/T) across diverse MDR-KP clinical populations remain limited. Methods: Su...

Retinoic acid maintains the primordial follicle reserve by inhibiting PI3K/Akt signaling

In female mammals, nonrenewable primordial follicles are orderly activated to maintain reproductive lifespan. However, the initiating regulator(s) of primordial follicle maintenance and activation remain poorly characterized. RA synthesis enzymes were mainly expressed in the pre-...

Cataract GWAS meta-analysis and multi-omics Mendelian randomisation inform disease mechanisms and candidate target prioritisation

Background Cataract is a highly prevalent cause of visual impairment and blindness worldwide. Although genome-wide association studies (GWAS) have mapped multiple cataract risk loci, further work is required towards translating these signals and integrating multi-omics evidence f...

Characteristics of meta-analyses of multi-indication drugs: a systematic review of systematic reviews

Multi-indication drugs (MIDs) are increasingly common, but their meta-analyses face methodological challenges due to heterogeneity across indications. This review aims to characterize the methodological and reporting approaches of meta-analyses evaluating MIDs. We conducted a sys...

Toxicities of cancer immunotherapy: clinical manifestations, underlying mechanisms, and management

Abstract Cancer immunotherapy, particularly immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T-cell (CAR-T) therapy, has transformed the treatment landscape of multiple malignancies. However, dysregulated immune activation can cause a wide range of toxicities tha...

A Tightly Interlayer Bonded, Synchronously In Situ Co‐Injectable, Wet‐Adhesive, Hierarchically Biofunctionalized Bilayer Hydrogel for Functional Attachment and Orderly Periodontal Regeneration

ABSTRACT Periodontitis, the sixth most prevalent global disease, causes tooth loss and systemic disorders, imposing a significant global burden. Functional regeneration of the periodontium remains a major challenge due to the hierarchical soft‐hard tissue interface and complex sp...

Osteoclastogenesis with FN1-associated cell differentiation, immune communication, and ECM remodeling in male SAMP6 mice

Early diagnosis and precise treatment of senile osteoporosis remain challenging. Herein, we apply a multi-omics strategy, integrating scRNA-seq and proteomics in the male 5-month-old senescence-accelerated mouse prone 6 (SAMP6) spontaneous aging model, to study early bone loss. T...

Grape seed-derived procyanidin alleviates gliadin p31–43-induced intestinal epithelial stress associated with ATF4 and autophagy–iron homeostasis

Gluten-derived gliadin p31–43 is a digestion-resistant peptide implicated in intestinal epithelial stress, but its mechanism of intestinal epithelial injury remains unclear. This study investigated the relationships among p31–43-induced endoplasmic reticulum (ER)–mitochondrial st...

Parenting styles and fertility intention: Mediating effects of childbearing beliefs and psychological resilience

China's declining fertility rate is partly due to low fertility intention among childbearing population. To understand family influence on young people's fertility intention and its underlying mechanisms, this study examines how parenting styles (authoritarian vs. permissive) aff...

Frailty and bone quality as the predictors of mechanical complications for patients after lumbar interbody fusion: a retrospective cohort study

Mechanical complications following lumbar interbody fusion are common in in elderly patients, particularly those with compromised bone quality. The MRI-based vertebral bone quality (VBQ) score assesses bone quality, while the modified frailty index (mFI) captures systemic physiol...

The association between passive anterior tibial subluxation and anterior cruciate ligament reconstruction failure

Abstract Purpose Increased passive anterior tibial subluxation (PATS) has been observed in patients with failed anterior cruciate ligament (ACL) reconstruction (ACLR). However, whether primary PATS is associated with future risk of graft failure and how PATS evolves over time rem...

Walking difficulty as a marker of high health need and education-related healthcare response in older adults: a cross-national multicohort study

Health systems need simple ways to identify older adults with high health need and to assess whether healthcare response is distributed according to need rather than social position. Walking difficulty is inexpensive to ascertain and widely harmonisable across ageing cohorts, but...

Cross-Scale Mixed Conduction in Organic Electrochemical Transistors: From Nanoscale Ion–Electron Coupling to Biointegrated Intelligence

Abstract Organic electrochemical transistors (OECTs) are emerging at the convergence of nanoscience, soft materials, and bioelectronics because they couple the ionic signals of living systems with amplified electronic readout through hydrated organic mixed ionic–electronic conduc...

A Sequence-to-Scaffold Platform Enables Programmable Carrier-Supported Biocatalysis for Nucleoside Analog Synthesis

Abstract Industrial biocatalysis increasingly requires strategies that convert enzyme discovery into robust catalyst systems for process implementation. Here, we report Spatially Programmable Assembly of Computationally Mined Enzymes (SPACE), a sequence-to-scaffold workflow coupl...