National University of Singapore

Vulnerable groups’ engagement with interventions to mitigate the health impacts of exposure to extreme temperature events: a qualitative systematic review

Abstract Extreme temperature events are becoming more frequent. Such events are defined as unusually hot weather persisting for at least two consecutive days (heatwave) or unusually cold weather persisting for at least two consecutive days (cold wave) within the context of geogra...

Genomic, transcriptomic, and molecular predictors of response to neoadjuvant therapy in locally advanced rectal cancer: a narrative review

Total neoadjuvant therapy (TNT) has emerged as a key treatment paradigm for locally advanced rectal cancer, reducing distant metastasis rates and facilitating organ preservation in selected patients. However, treatment response remains heterogeneous, highlighting the need for bio...

Tea and cognitive health in aging: Current evidence and future directions

The health benefits of tea drinking have been extensively studied, and in the past 20 years, there has been increasing interest in the role of tea drinking in promoting cognitive health among older adults. This review aims to analyze existing evidence on the benefits of tea drink...

Risk of new‐incident mental health diagnoses following SARS ‐ CoV ‐2 infection amongst children and young adults in Singapore: a retrospective cohort study

Background Mental‐health‐disorders in children/young adults increased post‐pandemic; however, the absence of linkage to COVID‐19 registries made direct attribution of psychological sequelae to acute infection challenging. Methods Healthcare‐claims databases in Singapore were util...

Nitro Reduction‐Based RNA Control and Ultrafast Release

ABSTRACT RNA protection and controlled release are critical for both fundamental research and therapeutic applications, yet the development of simple, efficient, and reversible post‐synthetic RNA modification strategies remains a significant challenge. Here, we introduce a straig...

Passive sampling reveals composition of airborne bacteria and fungi across five East African cities

Airborne microbes significantly influence environmental processes and human exposure, yet they remain poorly characterized in Africa. This study presents a regional survey of airborne bacterial and fungal communities across 10 sites in five East African countries: Burundi, the De...

A Multi-Modal Pre-training Framework-Driven Active Learning System for Enhanced Protein Evolution of Cs CE

Abstract Protein language models have shown strong potential in modeling fitness landscapes for directed evolution; however, their predictive accuracy and generalization to unexplored sequence space remain limited under few-shot learning conditions. Here, we present MmALS (Multi-...

Targeting FibroblastActivation Protein for PrecisionMedicine

Conspectus The advancement of precision medicine depends critically on well-defined molecular targets. Pathologically activated fibroblasts drive disease progression in cancer, fibrosis and chronic inflammation through sustained inflammation, extracellular matrix remodeling and p...

Nitro Reduction‐Based RNA Control and Ultrafast Release

RNA protection and controlled release are critical for both fundamental research and therapeutic applications, yet the development of simple, efficient, and reversible post-synthetic RNA modification strategies remains a significant challenge. Here, we introduce a straightforward...

Trinity Antennas: flexible active radio frequency systems with intrinsic heat spreading

Conformal, high-density, and high-power integration for radio frequency systems is critical to future wireless communications. Alumina ceramic offers significant potential owing to its ultra-low dielectric loss tangent. However, wireless systems that exploit alumina’s thermal adv...

Lighting up Metal Nanoclusters as Promising Molecular Emitters

Atomically precise metal nanoclusters (NCs) have emerged as promising optical materials in recent years. At the transition size between metal atoms and plasmonic metal nanoparticles, metal NCs exhibit elusive mechanisms underlying their photoluminescence (PL) properties. This fun...

A Technology-Blended Exercise Intervention for Cognitive Risk Reduction and Brain Health in Middle-Aged and Older Adults with Type 2 Diabetes in Singapore

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major modifiable risk factor for accelerated brain ageing, cognitive decline, and dementia. However, sustainable lifestyle interventions targeting cognitive health in at-risk older adult populations remain limited. This mixed-metho...

Wake-Up Call from the Past Investments

Asset impairment accounting requires firms to reassess their existing assets-in-place, namely, the outcomes of past investments, which enriches the information environment within the firm. We investigate whether this reassessment influences corporate investment strategies for lon...

Physics‐Informed Neural Networks for Flexoelectric Boundary Value Problems: A Reformulated Architecture for High‐ and Mixed‐Order Electromechanically Coupled Systems

ABSTRACT Flexoelectricity denotes a universal electromechanical coupling in dielectric materials, whereby strain gradients break local inversion symmetry and induce electric polarization. The resulting boundary value problem (BVP) is governed by a coupled multi‐physics system of...

Prognostic Stratification of Brain Metastases from Nonanaplastic Follicular Cell–Derived Thyroid Carcinoma: Results of an International Multicenter Retrospective Study

Background: Brain metastases (BMs) from nonanaplastic follicular cell–derived thyroid carcinoma (hereinafter referred to as non-ATC) are rare and not well characterized, with limited evidence guiding treatment and prognostic stratification. We aimed to describe clinical features,...

Autonomous intranasal delivery systems for central nervous system therapeutics

Intranasal delivery provides a rapid, non-invasive route to the central nervous system, bypassing the blood-brain barrier and first-pass metabolism. However, its therapeutic potential remains constrained by the nasal cavity's complex anatomy, the restricted surface area and perme...

Vision-Based Counting of Horticultural Seeds Using ViT-UNet Density Regression for Post-Harvest Quality Assessment

Reliable counting of horticultural seeds is important for seed grading, batch consistency assessment, packaging, sowing-rate control, and post-harvest quality evaluation. Manual counting is labor-intensive, whereas conventional image-processing methods can be sensitive to seed ad...

Making decisions about hormone replacement therapy for transgender and gender diverse youth in clinical settings in Singapore: a qualitative study

Objective: The objective of this study is to explore how clinical decision-making regarding hormone replacement therapy (HRT) for transgender and gender diverse (TGD) youth takes shape within clinical encounters involving healthcare providers, TGD youth, and their parents.Methods...

Understanding the needs and frustrations in adolescent idiopathic scoliosis: a qualitative interview study

Abstract Background Scoliosis is a common term used for a group of conditions that involve abnormal curvature and rotation of the spine, thorax, and trunk. If untreated, scoliosis may lead to severe trunk deformities, which consequently limit physical function, exercise capacity,...

Menopausal arthralgia and longitudinal changes in sex hormones and climacteric symptoms

Musculoskeletal discomfort (menopausal arthralgia) is the most prevalent and debilitating complaint during the menopausal transition. Despite its high prevalence, menopausal arthralgia has historically been overlooked, and establishing a direct association with menopause remains...