National University of Singapore

Targeting MDA5 induces immunogenic cell death and promotes anti-tumor immunity

Identifying targets to enhance tumor immunity is an urgent need. Although nucleic acid sensors play critical roles in promoting tumor immune clearance, their exceptionally low mutation rate in cancers suggests potential unexplored roles in tumor progression. Here, we demonstrate...

Neurobehavioural Associations of Recurrent Short Sleep in School‐Aged Children

ABSTRACT Recurrent cycles of weekday short sleep and weekend sleep extension have been shown to result in more prominent neurobehavioural impairments during subsequent weeks of sleep restriction in adolescents and young adults. Whether the same would be observed in school‐aged ch...

Global Incidence of All-Cause Dementia

Importance Global dementia incidence estimates are limited by underrepresentation of low- and middle-income countries and heterogeneous analytic methods. Due to these limitations, true understanding of the global dementia landscape remains incomplete. Objective To identify dement...

Settlement-informed boundary-adaptive excess pore water pressure prediction during vacuum preloading

Predicting excess pore water pressure (EPWP) fields during vacuum preloading remains difficult because EPWP sensors are sparse and the time-varying vacuum boundary is rarely recorded continuously. This study frames this problem as settlement-informed boundary adaptation rather th...

Dynamic Diffusion of Legal Compliance and Ethical Conduct among Construction Project Owners: An Epidemiological Modeling Approach

Abstract Construction industries worldwide face persistent challenges of ethical misconduct, contractual violations, and regulatory noncompliance, imposing substantial legal liabilities and undermining sustainable development. Although legal frameworks exist to govern owner behav...

Hardware‐Native Gaussian Sampling With Probabilistic Ising Machines for Modern Communication Paradigms

ABSTRACT Modern communication systems increasingly shift computation to edge devices, where post quantum signing, generative AI and semantic communication must operate under strict energy, latency and memory constraints. A central bottleneck in these workloads is Gaussian samplin...

Trajectory-Constrained Feature Transformation Optimization Framework for Stable Tabular Data Reprogramming

Tabular data reprogramming is a cornerstone of Data-Centric AI, which seeks to mathematically reconfigure raw features into more expressive and model-efficient representations. This process has traditionally relied on extensive manual engineering. Further, recent automated featur...

Sparse Electromagnetic-Compatibility Flexible Electrodes for High-Accuracy, Fast-Recognition Human–Computer Interfaces

Surface electromyography (sEMG) gesture recognition technology offers significant potential for enhancing human-computer interaction and rehabilitation engineering by providing an intuitive and noninvasive method of engagement. However, challenges such as electromagnetic interfer...

From Tool Calling to Loop Engineering: A Survey of Control, Feedback, Acceptance, and Self-Improvement in LLM-Based Agents

Agents built on large language models (LLMs) combine a model with tools, memory, verifiers, and software that decides when work starts, stops, and changes. This survey traces how these responsibilities moved from the model's response into the surrounding harness between 2020 and...

Does EQ-5D measure the most relevant aspects of health across cultures? Findings from a multi-country qualitative and card-sorting study

The EQ-5D is a widely used measure of health-related quality of life (HRQoL) in health services and economic evaluations globally. However, its cross-cultural content validity remains underexplored. This study assesses the relevance and adequacy of EQ-5D across diverse cultural c...

CNT-Mediated Integration of Pd and In2O3 Circumvents Activity–Stability Trade-Off in CO2 Hydrogenation to Methanol

Abstract Metal promotion is a widely adopted strategy to enhance the activity of indium oxide (In2O3) catalysts for CO2 hydrogenation to methanol. However, intimately contacted metal promoters on In2O3 often result in rapid catalyst deactivation, as excessive local H2 supply indu...

Effects of Nut Consumption on Body Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with Subgroup Analyses by Nut Fatty-Acid Profile

Background: Despite their high fat content, nut consumption is suggested to benefit body composition. However, it remains unclear whether nuts with different fatty-acid compositions affect body composition differently. This study aimed to assess the effects of monounsaturated fat...

Perioperative Hospital‐at‐Home Program: A Scoping Review

BACKGROUND: Hospital-at-Home (HaH) is an established model of care for medical patients, particularly following rapid expansion during the COVID-19 pandemic. In contrast, perioperative HaH remains in its early stages, with limited understanding of appropriate care delivery models...

Helical Anchor Pullout Using a Semifluidized Bounding Surface Plasticity Model

Abstract The ultimate vertical pullout capacity of single-helix anchors in sand was explored using the coupled Eulerian–Lagrangian (CEL) technique to account for large deformation processes. A semifluidized bounding surface plasticity model was incorporated in a novel manner to i...

Tuerkayana latens, a New Species of Land Crab from French Polynesia, with a Discussion on the Phylogeny of the Genus (Crustacea: Decapoda: Brachyura: Gecarcinidae)

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Interactions of pollen-stigma interface in fruit trees: A multiscale analysis of adhesion mechanisms

Abstract Inspired by sophisticated adhesion strategies in nature, physicochemical properties of pollen from three widely distributed fruit species (apple, pear, and kiwifruit) are investigated, and an novel adhesion mechanism for fruit tree pollination is proposed. Through simula...

High Coverage Does Not Guarantee Regression Detection: A Target-Blind Audit of Representative Task Panels for Versioned AI Coding Agents

Re-evaluating versioned artificial intelligence (AI) coding agents is expensive, motivating small task panels that represent a full benchmark. We audit whether such representativeness predicts regression-screening value (a regression is a task the previous configuration solved an...

How Instrumental and Expressive Ties Shape Team Resilience in Digitally Mediated Construction Projects: The Moderating Role of Communication Visibility

Abstract Construction projects often operate in dynamic environments where team resilience is vital for survival. Although social ties provide the structural potential for adaptation, the specific mechanisms that translate these connections into resilient performance, particularl...

A Scoping Review of Vibe Coding and AI-Assisted Programming in University Computing Education

Background: Generative AI coding tools are increasingly used in university computing education, including emerging practices commonly described as vibe coding. However, evidence on their educational effects is scattered across studies that differ in interaction patterns, instruct...

Next-Generation Water Quality Monitoring via Artificial Intelligence-Coupled Nanozymes

Abstract Safe water management requires rapid and highly sensitive analytical platforms capable of detecting contaminants in complex environmental matrices. Nanozymes are nanomaterials with enzyme-mimicking catalytic activity that offer remarkable advantages for field-deployable...