Nanjing Medical University

Multimodal Transformer Integrating CT and Pathology for Postoperative Risk Stratification in Stage I Non–Small Cell Lung Cancer

A biologically interpretable multimodal artificial intelligence framework outperformed guideline-based postoperative risk stratification for stage I non–small cell lung cancer and identified patients who would benefit from adjuvant therapy.

The CARM1–YIPF2 axis drives breast cancer progression and predicts poor prognosis

Objective To investigate the roles of CARM1 and its regulatory effect on YIPF2 in breast cancer progression. Methods Breast cancer cells were transfected with CARM1 siRNA to knock down CARM1 expression. Cell proliferation, apoptosis, migration, and invasion were assessed using Ed...

TyG-ABSI and TyG-WWI as insulin-resistance body shape markers of mortality in middle-aged and older adults within the cardiovascular-kidney-metabolic framework

Insulin resistance, adiposity, kidney dysfunction, and cardiovascular disease are closely interconnected in middle-aged and older adults and are central to the cardiovascular-kidney-metabolic (CKM) framework. Triglyceride-glucose (TyG)-related indices combine routine lipid, gluco...

Multimodal analysis of sleep disturbances and heart disease in older adults: a machine learning and exploratory path analysis approach

Sleep disturbances and heart disease are common among older adults, yet the psychological and functional pathways linking sleep symptoms to heart disease remain insufficiently characterized. This study examined the association between sleep disturbance indicators and heart diseas...

Density Modulated (Co‐W)@Ag Core‐Shell Microspheres as Magnetic Fillers of Liquid Metal E‐GaIn for Soft Intelligent Systems

Through innovative composition and structural design, this study develops core-shell microspheres featuring Co-W alloy cores and Ag shells. Their formation relies on the synergistic effect of solid-liquid interface dewetting, principle of energy minimization, and marangoni effect...

Serum Olink proteomics-based exploration of novel predictive biomarkers for necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is a life-threatening gastrointestinal emergency in preterm infants, yet reliable serum candidates for presymptomatic risk stratification remain lacking. In this exploratory study, serial pre-diagnostic serum samples from a prospective discovery co...

Multiregional single cell profiling reveals LGALS9 and CD44 mediated niche remodeling crosstalk in metastatic breast cancer

Abstract The transition from intraductal to invasive Breast cancer (BC) is driven by complex interactions within the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs), a key stromal component, critically influence extracellular matrix remodeling, immune modulatio...

Allostatic load, genetic susceptibility, and lung cancer risk: Evidence from a prospective cohort and integrative proteomic analyses

Allostatic load (AL), a composite measure of multisystem dysregulation associated with chronic stress, has been linked to lung cancer risk. However, its joint effects with genetic susceptibility and the biological pathways underlying this relationship remain unclear. We conducted...

Differential effects of PM2.5 constituents on tuberculosis infection and disease progression in 40,379 student close contacts

Abstract Rationale Outdoor PM2.5 has been increasingly implicated in tuberculosis, yet evidence has largely focused on total PM2.5 mass and has usually considered Mycobacterium tuberculosis (M. tuberculosis) infection and active tuberculosis separately. Whether specific PM2.5 che...

Secondhand smoke exposure and fetal loss in nonsmoking pregnant women: a meta-analysis

Abstract Background Recent meta-analyses have reported inconsistent pooled relative risks of miscarriage associated with secondhand smoke exposure. Methods We conducted a meta-analysis to examine the relationship between fetal loss and maternal secondhand smoke exposure during pr...

Molecular subclassification of MGMT-unmethylated high-grade glioma identifies divergent tumor states and therapeutic vulnerabilities

MGMT-unmethylated high-grade glioma (HGG) is associated with poor response to temozolomide and limited therapeutic options. However, substantial molecular heterogeneity exists within this clinically defined subgroup and remains insufficiently characterized. Transcriptomic and cli...

Cellular and spatial context of genetic convergence between insomnia liability and DTI ALPS perivascular diffusivity

Sleep has been linked to brain waste clearance and glymphatic/perivascular transport, yet whether insomnia shares genetic architecture with perivascular diffusivity remains unclear. Here we show that insomnia liability and diffusion tensor imaging measures along the perivascular...

Bioengineered Hybrid Nanovesicles Modulate the Immune Microenvironment with Targeted Drug Delivery for Esophageal Squamous Cell Carcinoma Therapy

Abstract Combining chemotherapy and immunotherapy shows great promise for treating esophageal squamous cell carcinoma (ESCC), but its effectiveness is hindered by the immunosuppressive tumor environment and challenges in drug delivery. Recent research has focused on cell membrane...

A Single-Cell Transcriptomic Map Reveals Platelet-Rich Plasma-Induced Endometrial Microenvironment Remodeling in Recurrent Implantation Failure

Abstract Intrauterine infusion of platelet-rich plasma shows clinical promise as a regenerative therapy for patients with repeated implantation failure, yet the precise cellular and molecular mechanisms governing its in vivo effects on the human endometrium remain poorly understo...

Triglyceride-Glucose Index and 10-Year Atherosclerotic Cardiovascular Disease Risk: Associations of Obesity-Related Indices in Two Nationally Representative Populations

BACKGROUND: The triglyceride-glucose (TyG) index has been associated with atherosclerotic cardiovascular disease (ASCVD) risk. However, the associations of TyG-related indices combined with obesity measures, including body mass index, waist circumference (WC), waist-to-height rat...

Microfocused ultrasound for facial and neck rejuvenation

Facial and neck skin laxity reflects age‑related changes in collagen fibers and deeper support structures. Growing patient demand for effective, non‑invasive tightening has driven interest in microfocused ultrasound (MFU) as a treatment modality. This study aims to evaluate the c...

IRP1 affects the long-term survival and function of iTregs by regulating ferroptosis and apoptosis

As an important classification of Tregs, iTregs play a critical role in inducing transplant immune tolerance. Iron metabolism is closely linked to iTreg function, and IRP1 serves as a central regulator of cellular iron homeostasis. However, the relationship between IRP1 and iTreg...

Bidirectional Mediation Effects of Body Mass Index and Inflammatory Markers on Assisted Reproductive Outcomes in Women With Polycystic Ovary Syndrome

OBJECTIVE: To evaluate the bidirectional mediation effects of body mass index (BMI) and inflammatory markers (neutrophil-to-lymphocyte ratio [NLR], systemic immune-inflammation index [SII], platelet-to-lymphocyte ratio [PLR]) on assisted reproductive technology (ART) outcomes in...

Non-invasive alterations of extra-pancreatic nerves in pancreatic ductal adenocarcinoma: a comparative study

Abstract Background Alterations in pancreatic innervation are characteristic of pancreatic ductal adenocarcinoma (PDAC) and are closely associated with poor prognosis. However, existing research has primarily focused on perineural invasion into intra-pancreatic nerves, with less...

Supraphysiological Citrate Exposure Drives Nonmonotonic Immunometabolic Reprogramming and Proinflammatory Activation in Monocytes/Macrophages

ABSTRACT Patients receiving continuous renal replacement therapy (CRRT) with regional citrate anticoagulation (RCA) frequently experience systemic citrate accumulation, yet its immunometabolic consequences remain poorly understood. Here, we examined how supraphysiological citrate...