Nanjing Medical University

Early gastric carcinoma with lymphoid stroma associated with a low risk of lymph node metastasis and favorable prognosis: a multicenter study in a Chinese population

Abstract Objective Gastric carcinoma with lymphoid stroma is a rare subtype of gastric carcinoma. The clinicopathological features and prognosis of early gastric carcinoma with lymphoid stroma (EGCLS) remain elusive, especially in Chinese populations. Methods In this study, we in...

The hDPSC-CM-derived peptide P1DC promotes osteogenic differentiation by regulating the p38/MAPK pathway

Human dental pulp stem cells (hDPSCs) are dental-derived mesenchymal stem cells with robust multipotent differentiation potential, indicating that they are promising for bone tissue engineering (BTE). We previously screened a secreted peptide, P1DC, derived from differentiated hD...

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

ABSTRACT Immune surveillance hinges on the precise regulation of molecular sentinels to maintain the equilibrium between physiological homeostasis and pathological distress. Central to this process is the sensing of exogenous pathogen‐associated molecular patterns (PAMPs) and end...

Waist-to-height ratio as the optimal predictor of non-alcoholic fatty liver disease among medical staff: a cross-sectional study

This study aimed to assess the health of medical staff via body composition analysis, examine associations between anthropometric indices and NAFLD, evaluate their predictive value for NAFLD, and compare their performance in identifying NAFLD. A total of 622 medical staff in the...

Multi‐Stimuli Responsive Phosphate Hybrids With Visible‐Light‐Excited Dual‐Mode Afterglow Toward Multifunctional Applications

ABSTRACT Dual‐mode afterglow emission is a notable photoluminescent phenomenon in which materials exhibit prolonged luminescence via thermally activated delayed fluorescence (TADF) and phosphorescence. Developing such dual‐mode materials through a simple preparation process is in...

A Novel tRNA Half mt‐5’‐tiRNA‐Tyr Promotes Colorectal Cancer Proliferation via Inducing HARS2 Succinylation

Transfer RNA-derived small RNAs (tsRNAs) are a novel class of small non-coding RNAs abundant in the bloodstream of cancer patients and involved in various physiological and pathological processes. However, the regulatory mechanisms and clinical significance of tsRNAs in colorecta...

Unveiling the Immune Mechanisms of Hypertension With Single‐Cell Transcriptome‐Wide Mendelian Randomization

Immune dysregulation is closely implicated in hypertension pathogenesis, yet specific therapeutic targets are lacking. We integrated expression quantitative trait loci (eQTLs) for genes expressed in 14 immune cell subsets (OneK1K) with two-sample Mendelian randomization (MR) and...

Piezo1 drives fibroblast activation in epidural fibrotic remodelling via the ET-1/HIF-1α pathway

Aims: Epidural fibrosis is a major cause of failed back surgery syndrome following laminectomy. While previous studies have focused primarily on the early phases of scar formation, fibrotic remodelling remains poorly understood. This study aimed to investigate the interaction bet...

Heatmap-seeded spatially grounded query Transformers improve astrocyte soma detection across Immunostains and scan resolutions

<title>Abstract</title> Background: Automated astrocyte quantification in human immunohistochemistry (IHC) is hindered by stain variability and dense clustering. Standard Transformers often miss faint somata due to agnostic initialization, while CNNs struggle with overlapping pro...

Air pollution-related proteomic signatures, molecular mediators, and AF-free life loss: A large-scale proteome-wide analysis

Background Air pollution is a major environmental risk factor for Atrial Fibrillation (AF). We aimed to derive robust, pollutant-specific proteomic signatures to elucidate the biological mechanisms and evaluate their potential risk-stratification utility. Methods We analyzed plas...

Sigh ventilation versus conventional protective ventilation in cardiac surgery: a proof-of-concept randomized controlled trial

Lung protective ventilation is crucial for preventing ventilator-induced lung injury in cardiac surgery. The protective role of a low tidal volume (V T ) has been established, whereas the added protection afforded by lung recruitment remains uncertain. We investigated whether sig...

Fructose directly remodels the translocase of the outer membrane to impair oxidative phosphorylation in podocytes

Excessive dietary fructose consumption contributes to the rapidly increasing prevalence of obesity, metabolic syndrome, and chronic kidney disease worldwide, and accumulating preclinical evidence has confirmed that excess fructose exposure provokes severe mitochondrial dysfunctio...

Plant-based diet and risk of cognitive decline among older adults: a community-based prospective cohort study

Background: Diet serves as a modifiable risk factor for cognitive decline, yet evidence on plant-based diets and cognitive ageing remains limited. We examined the association between plant-based diets and cognitive decline.Methods: A total of 6,721 participants from the Chinese L...

FOXA2 Transcriptionally Activates SIRT1 to Inhibit Cochlear Ferroptosis in Noise-Induced Hearing Loss

Background: Noise-induced hearing loss (NIHL) is a pervasive occupational health challenge, yet the individual susceptibility mechanisms remain unclear. Ferroptosis, an iron-dependent form of programmed cell death, has been implicated in cochlear hair cell damage. This study aims...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

LPA deficiency in follicular fluid linked to impaired oocyte maturation through BCAA metabolism-mediated mitochondrial dysfunction

Abstract Lysophosphatidic acid (LPA) is known to be crucial for oocyte developmental competence, but the underlying molecular mechanisms remain unclear. In this study, we investigated the mechanistic relationship between follicular fluid LPA levels and oocyte quality determinants...

Association between remnant cholesterol inflammatory index and new-onset stroke in different glycemic metabolic states: insights from the China health and retirement longitudinal study

The remnant cholesterol inflammatory index (RCII) has been proposed as a novel biomarker for lipid dysregulation and inflammation, and has also been suggested as a potential risk factor for diabetes. However, the association between RCII and the incidence of new-onset stroke acro...

Effect of SEEKflex-guided versus conventional intubation on hemodynamic responses in elderly hypertensive patients: a randomized controlled trial

In elderly patients with preexisting cardiovascular and cerebrovascular diseases, laryngoscopy and tracheal intubation can provoke substantial hemodynamic disturbances, including hypertension and tachycardia, which may precipitate major cardiovascular or cerebrovascular events an...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Dynamic Succession of the Early-Life Gut Microbiota and the Regulatory Role of Human Milk Oligosaccharides

Early-life nutrition and the gut microbiota interact to shape host health programming. During early-life development, spanning the neonatal period of initial gut colonization through infancy to toddlerhood, the gut microbiota undergoes dynamic succession driven by feeding pattern...