Monash University

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

ABSTRACT Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Patients with IBD receive therapy to correct these imbalances and achieve remission. However, most patients...

Cognitive Behavior vs Bright Light Therapy for Insomnia in Women Undergoing Chemotherapy for Breast Cancer

Importance Women receiving chemotherapy for breast cancer experience insomnia and fatigue, which impair quality of life. To date, no randomized clinical trial (RCT) has evaluated the use of cognitive behavior therapy for insomnia (CBT-I) and bright light therapy (BLT) both alone...

Conserving Australian lizards and snakes: an update on progress since 2017

The Action Plan for Australian Lizards and Snakes 2017 summarised results from the first comprehensive assessment of the Australian squamate fauna by the International Union for Conservation of Nature (IUCN), updating a more precursory assessment in 1993. This review outlines the...

Electronic cigarettes for smoking cessation

RATIONALE: Electronic cigarettes (EC) are handheld electronic vaping devices that produce an aerosol by heating a liquid. People who smoke, healthcare providers, and regulators want to know if EC can help people quit smoking, and if they are safe to use for this purpose. This upd...

Beyond the mountains: incorporating newly documented low-elevation records reshapes predicted habitat suitability for the threatened mountain skink Liopholis montana

The mountain skink (Liopholis montana) is an alpine–montane specialist listed as Endangered under Australian legislation, with its Victorian distribution traditionally considered restricted to elevations >900 m. However, recent discoveries have revealed repeated, disjunct low-ele...

Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study

Background Guideline-recommended clinical risk scores such as AusCVDRisk underestimate cardiovascular disease (CVD) risk in a substantial proportion of individuals who later experience events, with up to 65% initially classified as low or intermediate risk. This limitation is mos...

Women’s and health professionals’ needs and preferences informing the updated IMS recommendations

OBJECTIVE: This study aimed to identify and compare the priorities for content and accompanying resources of midlife women (MW) and health professionals (HPs) to inform the updated International Menopause Society (IMS) recommendations. METHOD: Two online multi-language surveys wi...

Presymptomatic plasma biomarkers in autosomal dominant Alzheimer’s disease: sequence and timing

Abstract Background Autosomal dominant Alzheimer’s disease (ADAD) serves as a model for presymptomatic biomarker discovery. Characterising the temporal profile of plasma biomarker levels in presymptomatic individuals may enhance understanding of disease pathogenesis, inform futur...

Pharmacological interventions targeting cognition and related clinical outcomes in vascular dementia: a systematic review and meta-analysis of randomized controlled trials

Abstract Purpose Randomized evidence for pharmacological interventions in vascular dementia (VaD) is fragmented. We conducted a VaD-focused, scale-specific systematic review and meta-analysis. Methods We searched four databases for English-language parallel-group randomized contr...

Candida auris uses nutrient sensing to modulate virulence and host immune responses

The emergence of Candida auris as a pathogen required host adaptation and evasion of mammalian immunity, but the mechanisms are poorly understood. We discovered that C. auris uses nutrient sensing to tune its virulence traits and modulate immune activation in changing environment...

Older adults and families/caregivers' experiences of access and use of emergency medical services (EMS): a study protocol for a qualitative evidence synthesis

Older adults account for one of the largest users of Emergency Medical Services (EMS) and require specialised care and tailored interventions during this time. The experiences of older adults and those important to them is crucial to ensure an age-friendly EMS. This review aims t...

The impact and evolution of environmental/occupational, behavioural, and metabolic risk factors on CVD burdens in the Asia–Pacific region from 1990 to 2023: a secondary analysis of the Global Burden of Disease Study 2023

Background Understanding epidemiological trends of the cardiovascular risk factors is integral in designing effective countermeasures in tackling cardiovascular diseases (CVD) in the Asia–Pacific. The study aims to examine the cardiovascular risk factor burden in the Asia–Pacific...

‘The wildness that one keeps in its cage’: Helen Garner and the rise of auto-true crime

This article proposes auto-true crime as a distinct hybrid mode of first-person true crime writing, one in which ethical meaning is negotiated through the narrating subject’s position as an affectively implicated witness. I formulate this mode through close readings of Helen Garn...

Momentum-based access and speed control for improved safety in heterogeneous road networks

The increasing variety of means of transportation, including light vehicles like e-scooters and e-bikes, together with the increasing weight of conventional vehicles due to electrification and consumer preferences for SUVs, are raising serious concerns regarding the safety of roa...

Structure-guided allosteric modulation of the delta opioid receptor

Abstract Opioid analgesics remain essential for pain management but are associated with significant adverse effects, including respiratory depression, tolerance, and dependence. The δ-opioid receptor (δOR) represents a promising therapeutic target for developing safer opioid anal...

P1.172. Comparison of Intraoperative Complications in Obese vs Non-Obese in Oesophageal Cancer Surgery

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Obesity is a substantial public health issue. A high body mass index (BMI) can increase surgical technical challenges, resulting in higher rates of intraoperative and postoperative complications....

P1.153. Dietitian-Led Integration of CT Body Composition Analysis in Oesophagogastric Cancer Care

Abstract Topic Esophageal Cancer: Other Background Malnutrition and poor muscle health are prevalent in patients with oesophagogastric cancer and are associated with poor outcomes. However, body composition assessment is not routinely implemented in clinical practice. This projec...

Earliest simultaneous multi-color optical observations of GRB 230328B: from 41 seconds to the host-galaxy identification

Abstract We present a multiwavelength study of the long-duration gamma-ray burst GRB 230328B, combining prompt γ-ray observations with exceptionally early simultaneous optical photometry and extensive X-ray, radio, and host-galaxy follow-up. NUTTELA-TAO began simultaneous g′r′i′...

Tail-risk in real-time electricity pricing: Experimental evidence on preferences, perception and comprehension

Do households comprehend the nature of tail-risks inherent to real-time electricity pricing (RTP) plans? We develop a randomized and incentivized experiment calibrated to real-world price distributions and find that (a) probabilistic risk disclosure, beyond that offered in standa...

Prediagnostic circulating 25-hydroxyvitamin D and prostate cancer-specific survival: a collaborative pooled analysis of 13 prospective studies

Abstract Background Previous research suggests higher risk of prostate cancer diagnosis in men with high vitamin D serology, but there are limited data related to prostate cancer survival. In this study, we examine the associations between prediagnostic circulating levels of 25-h...