Monash University

Data-Driven Fatigue Trajectories in Multiple Sclerosis and Their Predictors

Fatigue is one of the most disabling symptoms of multiple sclerosis (MS), yet its longitudinal trajectories and determinants remain poorly characterized. We aimed to identify trajectories of cognitive and physical fatigue in relapsing-remitting MS (RRMS) and to determine baseline...

Unpacking the complexity of contraceptive use among Chinese university students 2014-2024: a systematic review and meta-analysis.

High risks of unintended pregnancies and abortion have been reported among Chinese university students; however, their contraceptive use remains poorly understood. This study synthesised Chinese university students' contraceptive usage to inform the development of context-specifi...

Scaling up Genomics

Introduction: Genomic testing has substantial diagnostic and clinical value in nephrology, yet integrating testing into routine care requires service-level changes to ensure timely and equitable access. Methods: We conducted an observational cohort study at four tertiary centres,...

Monthly or menstrual? A scoping review of catamenial epilepsy and non‐menstrual seizure rhythms

OBJECTIVE: Despite the reported high prevalence of catamenial epilepsy (CE), the condition remains poorly defined, with lack of consensus on what entails a menstrual-related seizure exacerbation. Emerging evidence of multiday cycles of seizure activity, including about-monthly cy...

Clearance of Treponema pallidum from oral and anal sites after treatment of secondary syphilis: results from a multi-centre, prospective, cross-sectional study

Background Syphilis is increasing worldwide, and secondary syphilis may represent its most infectious stage. Scarce data exist on Treponema pallidum clearance after treatment. We aimed to determine the frequency and load of T. pallidum mucosal shedding, and time to clearance foll...

Stroke survivors’ health priorities and targeted interventions in home-based post-discharge rehabilitation

<title>Abstract</title> Background This study aimed to describe health problems of the stroke survivors and the corresponding nursing interventions implemented during 12-week home-based post-discharge rehabilitation. Methods This was a descriptive secondary analysis within the co...

Following the rules: which type 1 diabetes guidelines, protocols and recommendations are tertiary clinics in Australia following? A quantitative study

OBJECTIVES: This study characterises the use of type 1 diabetes (T1D) guidelines and protocols in Australian T1D clinics working with paediatric patients, and determines if management practices align with T1D-specific guidelines. METHODS: T1D clinic service leaders responded to a...

A systematic review of early neuroimaging and neurophysiological biomarkers for post-stroke mobility prognostication

Abstract Background Accurate prognostication of mobility outcomes is essential to guide rehabilitation and manage patient expectations. The prognostic utility of neuroimaging and neurophysiological biomarkers remains uncertain when measured early post-stroke. This systematic revi...

Anxiety and mood disorders from childhood to adulthood in very preterm and term-born individuals

BACKGROUND: Very preterm (VP) birth has been associated with higher rates of anxiety and mood disorders, but the emergence and persistence from childhood to adulthood is unknown. This study examined prevalence rates and early risk factors of these disorders in VP and term-born in...

Association between prior ICU admission for drug overdose and ICU readmission: A retrospective registry-based study

Objective We aimed to investigate patients discharged alive from hospital following an ICU admission for drug overdose and whether exposure of prior overdose-related ICU admission was associated with a future ICU readmission. Design, setting, participants This multicentre registr...

Fibrinogen Early In Severe Trauma studY II (FEISTY II): study protocol for a randomised clinical trial of fibrinogen concentrate vs cryoprecipitate in traumatic haemorrhage in Australia and New Zealand

Haemorrhage is a leading cause of preventable death amongst severe trauma patients and is often complicated by hypofibrinogenaemia. Fibrinogen replacement can be achieved using fibrinogen concentrate (FC) or Cryoprecipitate (Cryo), but comparative evidence in traumatic haemorrhag...

Steric stabilizers inhibit or enhance enzymatic digestion depending on the internal nanostructure of lipid nanoparticles

Abstract Lipidic nanoparticles (LNPs), including liposomes and cubosomes, are widely employed drug delivery systems owing to their biocompatibility and capacity for stimuli-responsive ‘smart’ drug release. Steric stabilizers, including DSPE-PEG-2000 and Pluronic F127, are commonl...

Effect of the November 2023 Medicare Benefits Schedule PSA Testing Reform on National Utilisation, Diagnostic Activity, and Health-System Expenditure in Australia

Background/Objectives: On 1 November 2023, the Medicare Benefits Schedule (MBS) introduced major reforms to prostate-specific antigen (PSA) testing in Australia, extending the minimum re-test interval for average-risk men (item 66655) from 12 to 23 months and introducing a new an...

Stellar Interpretation of Meteoritic Data and PLotting for Everyone (SIMPLE): Isotope Mixing Lines for Six Sets of Core-collapse Supernova Models

Abstract Bulk meteorites and their inclusions exhibit, for many chemical elements, isotopic variability produced by nucleosynthetic events in stars and supernovae before the formation of the Sun. While the exact astrophysical origins of these variations are still a matter of deba...

Effectiveness of bitter almond (Amygdalus communis L. var. Amara) gum as a prebiotic on glycemic indices, oxidative stress, and antioxidant biomarkers in women with type 2 diabetes mellitus: a randomized, placebo-controlled trial

Type 2 diabetes mellitus (T2DM) is marked by hyperglycemia, oxidative stress, and systemic inflammation. Prebiotics, such as bitter almond gum ( Amygdalus communis L. var. amara ), have the potential to influence gut microbiota and metabolic parameters, suggesting their role as d...

Impact of socioeconomic status on treatment and survival in multiple myeloma in Australia

<title>Abstract</title> Outcomes in multiple myeloma (MM) have improved significantly but remain heterogeneous. We assessed the impact of non-biological social determinants of health on treatment and survival outcomes in Australia using data from the Australian and New Zealand My...

Hypothermia in the intensive care unit after surgery: a registry based retrospective cohort study

Background Hypothermia is common in patients admitted to the ICU after surgery; however, its relationship with postoperative outcomes has not been fully explored. This study investigates the association between postoperative hypothermia in the ICU and patient mortality. Methods R...

Clustered coloring of graphs excluding a subgraph and a minor

A graph coloring has bounded clustering if each monochromatic component has bounded size. Equivalently, it is a partition of the vertices into induced subgraphs with bounded size components. This paper studies clustered colorings of graphs, where the number of colors depends on a...

Co-designed development of a vocational education and training program for peer health and social care navigators in Australia

<title>Abstract</title> Background Peer health navigators (lay patient navigators) are increasingly used to support consumers to access and navigate health and social care systems, particularly for populations experiencing barriers to care. Despite growing evidence of their effec...

The Saxl hypergraph of a permutation group

Given a permutation group G ≤ Sym(Ω), a subset B of Ω is said to be a base if its pointwise stabiliser in G is trivial, and thebase size b(G) is the minimum size of a base. In the notable case b(G) = 2, Burness and Giudici define the Saxl graph of G to be the graph on Ω with base...